Pulmonary Sarcoidosis: A Prospective Evaluation of Glucocorticoid Therapy

Young, Robert L.; Harkleroad, Lionel E.; Lordon, Robert E.; Weg, John G.

doi:10.7326/0003-4819-73-2-207

Cited by 49 publications

(12 citation statements)

References 12 publications

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“…ZAKI et al [65] enrolled 183 patients into a controlled, double-blind therapeutic study and found only trends towards a significant improvement in a treated group. YOUNG et al [66] showed no benefit of treatment at six months or 1-2 yrs.…”

Section: Corticosteroids and Clinical Efficacymentioning

confidence: 99%

“…YOUNG and co-workers [66,67] compared treatment for six months (six patients) and up to 2 yrs (six patients) against no treatment and assessed outcome at 1-2 yrs and, in a subsequent report, at 10-15 yrs: 11 of the 12 treated patients received no treatment beyond the 2 yrs period. Both of these studies showed no significant differences between treated and untreated groups at the end of the follow-up period.…”

Section: Effect Of Corticosteroids On Long-term Outcomementioning

confidence: 99%

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Corticosteroids in sarcoidosis: friend or foe?

Bois¹

1994

Eur Respir J

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Section: Corticosteroids and Clinical Efficacymentioning

confidence: 99%

Section: Effect Of Corticosteroids On Long-term Outcomementioning

confidence: 99%

Corticosteroids in sarcoidosis: friend or foe?

Bois¹

1994

Eur Respir J

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“…The adverse effects of corticosteroids on the course of sarcoidosis have been reported by several investigators (Young et al 1970;Israel et al 1973;Selroos et al 1974;Harkleroad et al 1982;Eule et al 1986;Izumi 1994;Gottlieb et al 1997;Reich 2002). For example, Eule et al (1986) reported an evaluation of the long-term influence of oral corticosteroid therapy on the natural course of asymptomatic pulmonary sarcoidosis.…”

Section: Discussionmentioning

confidence: 90%

“…Other sarcoidosis patients should be observed without therapy because of the potential for spontaneous remission (Silver and Messner 1994;Newman et al 1997). There have been many reports showing evidence of adverse outcomes in sarcoidosis patients systemically treated with corticosteroids (Young et al 1970;Israel et al 1973;Selroos et al 1974;Harkleroad et al 1982;Eule et al 1986;Izumi 1994;Gottlieb et al 1997;Reich 2002). Meanwhile, topical corticosteroid eye drops are efficient and commonly used for ocular sarcoidosis (Silver and Messner 1994;Newman et al 1997).…”

Section: Long-term Use Of Corticosteroid Eye Drops Delays the Spontanmentioning

confidence: 99%

“…In this preliminary report, we examined the effects of such eye drops on serum angiotensin converting enzyme (ACE) and BHL on chest radiograph in patients with stage I pulmonary sarcoidosis and found that the topical corticosteroid therapy appeared to influence the clinical course of pulmonary sarcoidosis, inducing some delay in the spontaneous remission in the long-term usage, as shown in the case of systemic corticosteroid treatment of pulmonary sarcoidosis (Young et al 1970;Israel et al 1973;Selroos et al 1974;Harkleroad et al 1982;Eule et al 1986;Izumi 1994;Gottlieb et al 1997;Reich 2002).…”

Section: Long-term Use Of Corticosteroid Eye Drops Delays the Spontanmentioning

confidence: 99%

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Long-Term Use of Corticosteroid Eye Drops Delays the Spontaneous Remission of Pulmonary Sarcoidosis

Nara

Sasamori

Shimura

et al. 2004

Tohoku J. Exp. Med.

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Topical corticosteroid eye drops are commonly used for ocular sarcoidosis. That systemic absorption of corticosteroids by eye drops may influence the clinical course of sarcoidosis may be speculated because it has been reported that the serum concentration of corticosteroids after drop administration was dose-related. To evaluate the effects of corticosteroid eye drops on the clinical course of patients with stage I pulmonary sarcoidosis, we compared the serum levels of angiotensin converting enzyme (ACE) and bilateral hilar lymphadenopathy (BHL) on chest radiographs of group CS, which is consisted of patients who received topical therapy of betamethasone in the form of eye drops for anterior uveitis, and group CN, which is consisted of patients who did not receive any medications throughout the entire course of the disease. Although the serum ACE level was not significantly different between groups CS and CN at the time of the diagnosis of pulmonary sarcoidosis, the level of serum ACE in group CS was significantly higher than that in group CN 20 months after the topical corticosteroid treatment (24 IU/ml and 16 IU/ml, respectively). Further, the size of BHL on chest radiography in group CS was significantly larger than that in group CN 20 months after the topical treatment (82% and 37% of before control, respectively). These findings suggest the possibility that the topical corticosteroid therapy influenced the clinical course of pulmonary sarcoidosis, inducing some delay in the spontaneous remission in the longterm course.angiotesin converting enzyme; bilateral hilar lymphadenopathy; betamethasone eye drops; spontaneous remission; pulmonary sarcoidosis

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