Pulmonary sarcoidosis: An important differential diagnosis in transbronchial lung biopsies

Mahapatra, Qury S; Sahai, Kavita; Rathi, KR; Singh, Sankalp; Sharma, Satendra

doi:10.4103/0970-2113.129839

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…We pursued for tissue diagnosis in all patients as histopathological demonstration is the most convincing and definitive mode of diagnosis [22]. Granulomatous inflammation was found in 51 biopsies (75%).…”

Section: Articlementioning

confidence: 99%

Sarcoidosis at the Pulmonary Medicine Department of a tertiary care hospital in Mumbai. Our experience and The New Modified Criteria Clinical Radiological Physiological (TNMC CRP) score for sarcoidosis: A novel proposition to assess the functional status

Utpat

Sasikumar

Desai

et al. 2021

Monaldi Arch Chest Dis

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Sarcoidosis is a multisystemic granulomatous disease most commonly involving the pulmonary system and having a myriad of manifestations. However literature is scanty pertaining to the profile and scoring system in sarcoidosis. This study was undertaken to understand the profile of sarcoidosis and an endeavor to assess the functional status with a simplified scoring system. This was an observational study undertaken in the department of Pulmonary Medicine at a tertiary care. The profile of these patients was studied in terms of clinical features, radiological findings, the New Modified Criteria Clinical Radiological Physiological (TNMC CRP) score, six-minute walk distance (6MWD), spirometry, arterial blood gas parameters, serum angiotensin converting enzyme (ACE) levels and tissue biopsy histopathology. The 68 patients included 41 women and 27 men with a mean age of 42.7 years. They comprised of 18 (27%), 39 (57%), 4 (6%), 7 (10%) cases of stage 1, 2, 3, 4 sarcoidosis respectively. Most common presenting symptom and sign was progressive dyspnea 49 (72%), and peripheral lymphadenopathy 15 (22%). Serum ACE was elevated in 57 (83%). The average 6MWD was 360 meters. Most common high resolution computed tomography (HRCT) finding was mediastinal lymphadenopathy and peri-bronchovascular nodules. Spirometry was restrictive abnormality in 48 (96%) patients. Evidence of pulmonary hypertension (PH) was present in 32 (47%) patients. Tissue diagnosis revealed granulomatous inflammation in 51 biopsies with a transbronchial lung biopsy (TBLB) yield of 62%. The average TNMC CRP score was 5. There was a positive correlation between this score and 6MWD which was statistically significant. The score correlated with the functional status. Diagnosis of sarcoidosis warrants a comprehensive and multimodality approach. HRCT and tissue biopsy are the most important diagnostic armamentariums. Modified simplified scores help assess the functional status of the disease.

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Section: Articlementioning

confidence: 99%

Sarcoidosis at the Pulmonary Medicine Department of a tertiary care hospital in Mumbai. Our experience and The New Modified Criteria Clinical Radiological Physiological (TNMC CRP) score for sarcoidosis: A novel proposition to assess the functional status

Utpat

Sasikumar

Desai

et al. 2021

Monaldi Arch Chest Dis

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“…[ 3 4 5 6 7 8 9 10 11 ] In India, it predominantly occurs during fourth to the fifth decade of life. [ 12 ]…”

Section: Discussionmentioning

confidence: 99%

Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review

et al. 2017

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Gastric sarcoidosis is a very rare manifestation of sarcoidosis. Only few case reports have been described in the literature. We present a case of coexisting gastric and pulmonary sarcoidosis in a 56-year-old female, who presented with gastrointestinal symptoms. Gastric mucosal biopsies, transbronchial needle aspiration, and endobronchial mucosal biopsies revealed noncaseating granulomas. This case report emphasizes on early evaluation of other organ system and initiation of treatment.

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“…A systemic disease with protean manifestations, diagnosis of sarcoidosis requires a high index of suspicion and demonstration of non-caseating granulomas 1. Other conditions such as tuberculosis, chronic fungal infections and lymphoma have to be excluded.…”

Section: Descriptionmentioning

confidence: 99%

Uncommon cause for anorexia and weight loss

et al. 2016

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Pulmonary sarcoidosis: An important differential diagnosis in transbronchial lung biopsies

Cited by 4 publications

References 6 publications

Sarcoidosis at the Pulmonary Medicine Department of a tertiary care hospital in Mumbai. Our experience and The New Modified Criteria Clinical Radiological Physiological (TNMC CRP) score for sarcoidosis: A novel proposition to assess the functional status

Sarcoidosis at the Pulmonary Medicine Department of a tertiary care hospital in Mumbai. Our experience and The New Modified Criteria Clinical Radiological Physiological (TNMC CRP) score for sarcoidosis: A novel proposition to assess the functional status

Gastric and pulmonary sarcoidosis complicated by hypercalcemia and acute renal failure: Case report and literature review

Uncommon cause for anorexia and weight loss

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