Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

Yalçın, Burcu; Bekçi, Taha Tahir; Kozacıoğlu, Sümeyye; Bölükbaş, Özden

doi:10.1016/j.rmcr.2019.02.002

Cited by 13 publications

(18 citation statements)

References 19 publications

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“…Pre-operative diagnosis, when feasible, is helpful to plan the best therapeutic strategy. It is well known that PSP is characterized by two different cell populations, surface and round stromal cells, typically organized in four architectural patterns: papillary, sclerotic, solid and hemorrhagic [ 5 , 6 , 7 , 8 , 9 ]. The cytological features parallel these major histological patterns; at least two (more frequently the papillary and solid patterns) of the four architectural patterns occur in all patients, and three of the patterns are found in 95% of patients [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

et al. 2021

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Pulmonary sclerosing pneumocytoma is a rare benign pulmonary tumor of primitive epithelial origin. Because of the unspecific radiological features mimicking malignancies and its histological heterogeneity, the differential diagnosis with adenocarcinoma and carcinoid tumors is still challenging. We report our experience of two cases of sclerosing pneumocytoma, as well as a review of the literature. Immunohistochemical findings showed intense staining of the cuboidal epithelial cells for cytokeratin-pool and TTF-1, with focal positivity for progesterone receptors. Round and spindle cells expressed positivity for vimentin, TTF-1 and focally for the progesterone receptor. Cytologic diagnosis of pulmonary pneumocytoma requires the identification of its dual cell population, made up of abundant stromal cells and fewer surface cells. Since the pre- and intraoperative diagnosis should guide surgical decision making, obtaining a sufficient specimen size to find representative material in the cell block is of paramount importance.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

et al. 2021

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“…PSP is composed of four major histologic patterns: papillary, sclerotic, solid, and hemorrhagic [ 9 ]. When the papillary component is predominant, it is often pathologically misdiagnosed as adenocarcinoma [ 10 ]. When the solid component is predominant, it could be misdiagnosed as carcinoid [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

“…This tumor is also known for its difficult preoperative diagnosis since it possesses four typical histological structural patterns in the same neoplasm: papillary, sclerotic, solid, and hemorrhagic [ 9 ]. Because of the histological complication, PSP is often misdiagnosed as adenocarcinoma or carcinoid [ [10] , [11] , [12] ]. In recent years, with the prevalence of transbronchial cryobiopsy (TBLC), we are able to obtain larger specimens than previously.…”

Section: Introductionmentioning

confidence: 99%

A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy

Muto

Kuse

Inomata

et al. 2021

Respiratory Medicine Case Reports

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Background The preoperative diagnosis of pulmonary sclerosing pneumocytoma (PSP) is complicated since PSP has several histological structural patterns in the same neoplasm; hence, it is sometimes pathologically misdiagnosed as adenocarcinoma or carcinoid. In recent years, with the prevalence of transbronchial cryobiopsy (TBLC), we are able to obtain larger specimens than previously. However, to date, there have been no reports describing PSP diagnosed using TBLC. Case reports A 43-year-old man was referred to our hospital for an abnormal lesion in the left lung discovered on routine health examination. A computed tomography scan of the chest revealed a 14-mm heterogeneous round nodule with surrounding ground-glass opacity in the left lower lobe. The tumor size increased to 18 mm in three weeks, and he developed bloody sputum. TBLC was performed using radial endobronchial ultrasonography and fluoroscopy. An occlusion balloon and prophylactic epinephrine were used to prevent severe bleeding. Histologically, epithelioid cells with solid proliferation, various papillary lesions, and hemosiderin-laden histiocytes were observed. Immunohistochemical staining revealed the histiocytes positive for thyroid transcription factor-1 and vimentin, and the type II pneumocyte-like-cells positive for cytokeratin 7. The tumor was preoperatively diagnosed as a PSP; the patient underwent left basal segmentectomy and consequently, a final diagnosed of PSP was formulated. Conclusion We report the first case of PSP preoperatively diagnosed using TBLC. Therefore, cryobiopsy could be beneficial in the preoperative diagnosis of PSP.

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“…The preoperative differential diagnosis that occurs in patients with SFTP is any mass lesion in the chest, ranging from pulmonary carcinoma to various intrapleural sarcomas [4] . In low resource setting, misdiagnosis is possible between SFTP and pulmonary sclerosing pneumocytoma (PSP) [5] because of the similarity of signs and symptoms and limited investigations [6] , [7] . Based on the description above, we are interested in reporting a case of solitary fibrous tumors of pleura using the surgical case report (SCARE) 2020 guideline [8] .…”

Section: Introductionmentioning

confidence: 99%

A female with solitary fibrous tumor pleura mimicking pulmonary sclerosing pneumocytoma in low resource setting: A case report

Sakina

Marhana

Jiwangga³

2022

International Journal of Surgery Case Reports

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Pulmonary sclerosing pneumocytoma, a rare tumor of the lung

Cited by 13 publications

References 19 publications

Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

A case of pulmonary sclerosing pneumocytoma diagnosed preoperatively using transbronchial cryobiopsy

A female with solitary fibrous tumor pleura mimicking pulmonary sclerosing pneumocytoma in low resource setting: A case report

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