Pulmonary sclerosing pneumocytoma in an 18-year-old male patient

Abstract

Rationale: Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor of the lung, mostly presented in Asian middle-aged women. Initially, it was considered as a vascular origin tumor, but then research evidence showed that it was derived from natural epithelial tissue. On imaging, this tumor may be found as a solitary well-circumscribed lung parenchymal lesion, and is often located in juxtapleural or juxtafissural positions. On histopathology, it consists of cuboidal surface cells and stromal round cells, both of which are positive for thyroid transcription factor-1. Here we report a case of a young PSP male patient and review the relevant literature in order to improve our understanding of this disease. Patient concerns: An 18-year-old man was referred to our hospital after accidentally finding a lesion on chest X-ray. Contrast-enhanced computed tomography showed a soft tissue mass with homogeneous enhancement in the left lower lobe posterior segment. Diagnoses: The diagnosis of PSPs was confirmed by histopathological examination. Interventions and outcomes: The patient underwent a thoracoscopic wedge resection and was followed-up after that. One month later, he had good performance status with no recurrent tumors. Lessons: PSP in a young man is really uncommon, and is confused with malignant tumors. A histopathological examination is considered as the diagnostic gold standard for this uncommon tumor. Surgery is the main treatment.

Solitary pulmonary nodule in an early adolescent

“…This tumour is epithelial in nature and shows thyroid transcription factor-1 positive cuboidal surface cells and stromal round cells on histology. Surgical resection is considered as curative as the recurrence risk is negligible 12…”

A female with solitary fibrous tumor pleura mimicking pulmonary sclerosing pneumocytoma in low resource setting: A case report

“…An SFTP occurs in a wide age range (5 to 87 years), often found to occur at the age of the sixth and seventh decades, with quite the same frequency in both sexes [4] . The diagnosis of SFTP and PSP can be distinguished, one of them by using dynamic CT-Scan which dynamic CT-Scan can provide a more accurate picture of the lesion in PSP cases [9] . Dynamic CT-Scan was not performed in our case due to resource constraints.…”

Pulmonary Sclerosing Pneumocytoma: A Pre and Intraoperative Diagnostic Challenge. Report of Two Cases and Review of the Literature

“…Preoperative cytologic and histological findings of PSP are limited to few case reports, in which computed tomography (CT)-guided FNA, EBUS-TBNA or intraoperative frozen sections (FS) often led to misdiagnosis. Table 2 and Table 3 summarize cytological findings described in literature since 2010 after CT-guided FNA [ 12 , 14 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ] and EBUS-TBNA [ 25 , 26 ], respectively. In almost all cases of preoperative CT-guided FNA, both stromal and surface cells, organized in at least two architectural patterns, were found.…”