Pulmonary SP-A: Forms and Functions

Gupta, Asha; Gupta, Rajesh Kumar

doi:10.1007/978-3-7091-1065-2_24

Cited by 3 publications

(4 citation statements)

References 195 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, four types of amniotic surfactant proteins have been characterized in humans: SP-A, SP-B, SP-C, and SP-D (Chaiworapongsa et al, 2008-2). The SP-A is involved in the synthesis, regulation, and homeostasis of surfactants (Chaiworapongsa et al, 2008-2;Gupta and Gupta, 2012).…”

Section: Discussionmentioning

confidence: 99%

Canine amniotic fluid at birth: From a discarded sample to a potential diagnostic of neonatal maturity

Riva

Filipe

Pavlović

et al. 2023

Animal Reproduction Science

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Canine amniotic fluid at birth: From a discarded sample to a potential diagnostic of neonatal maturity

Riva

Filipe

Pavlović

et al. 2023

Animal Reproduction Science

View full text Add to dashboard Cite

“…The collectin family is a prominent example among lectin categories [72][73][74][75]. A number of infectious and noninfectious diseases have been associated with variant alleles influencing the expression and function of proteins, most often as disease modifiers [68,72].…”

Section: Smbl Genotyping and Genetic Polymorphismsmentioning

confidence: 99%

“…Lung SP-A and SP-D belong to collectin family of lectins. These lectins bind to several microorganisms, resulting in their killing, and enhancing their phagocytosis by alveolar macrophages [73,74]. SP-A and SP-D are capable of interaction with proteases such as MASP-1, -2 and can trigger the lectin complement pathway.…”

Section: Role Of Airway Epithelial Cellsmentioning

confidence: 99%

Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs

Gupta

2021

Mol Cell Biochem

Self Cite

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19) is an infectious disease caused by a virus called "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)." In the majority of patients, infection with COVID-19 may be asymptomatic or may cause only mild symptoms. However, in some patients, there can also be immunological problems, such as macrophage activation syndrome (CSS) that results in cytokine storm syndrome (CSS) and acute respiratory distress syndrome (ARDS). Comprehension of host-microbe communications is the critical aspect in the advancement of new therapeutics against infectious illnesses. Endogenous animal lectins, a class of proteins, may perceive non-self glycans found on microorganisms. Serum mannose-binding lectin (sMBL), as a part of the innate immune framework, recognizes a wide range of microbial microorganisms and activates complement cascade via an antibody-independent pathway. Although the molecular basis for the intensity of SARS-CoV-2 infection is not generally understood, scientific literature indicates that COVID-19 is correlated with unregulated activation of the complement in terms of disease severity. Disseminated intravascular coagulation (DIC), inflammation, and immune paralysis contribute to unregulated complement activation. Pre-existing genetic defects in MBL and their association with complement play a major role in immune response dysregulation caused by SARS-CoV-2. In order to generate anti-complement-based therapies in Covid-19, an understanding of sMBL in immune response to SARS-CoV-2 and complement is therefore essential. This review highlights the role of endogenous sMBL and complement activation during SARS-CoV-2 infection and their therapeutic management by various agents, mainly plant lectins, since antiviral mannose-binding plant lectins (pMBLs) offer potential applications in the prevention and control of viral infections.

show abstract

“…In comparison, composite casting is a relatively simple process by which the mechanical stirring is used in the production of MMCs and can be easily scaled as required. This process involves the addition of reinforcement particles into the semi-solid metal (SSM) either before or during stirring of the melt [2,3] . Aluminum matrix composites have received considerable attention because they can meet this requirement.…”

Section: Introductionmentioning

confidence: 99%

Aluminum reinforcement by gas tungsten arc welding

Sarajan

2012

Science and Engineering of Composite Materials

View full text Add to dashboard Cite

Aluminum is a light metal and is widely used in a variety of industries. Aluminum-silicon has good casting properties but does not offer any suitable tribological properties. Therefore, in this study surface composite coating was performed by the gas tungsten arc welding (GTAW) process, which increased hardness up to 34 HV, which is nearly two times compared to untreated specimens. This process is done by composite manufacturing with the silicon carbide reinforcement particles in the matrix of eutectic aluminum-silicon alloy. The mixed powder is deposited on the surface during melting by travelling the arc of GTAW. The desired optimum performance condition is achieved by arc current 75 amp, 1 g of poly vinyl alcohol (PVA) binder, 65 wt. % of aluminum powder and 15 wt. % of silicon carbide.

show abstract

Pulmonary SP-A: Forms and Functions

Cited by 3 publications

References 195 publications

Canine amniotic fluid at birth: From a discarded sample to a potential diagnostic of neonatal maturity

Canine amniotic fluid at birth: From a discarded sample to a potential diagnostic of neonatal maturity

Status of mannose-binding lectin (MBL) and complement system in COVID-19 patients and therapeutic applications of antiviral plant MBLs

Aluminum reinforcement by gas tungsten arc welding

Contact Info

Product

Resources

About