Pulmonary¹²⁹Xe Magnetic Resonance Gas-exchange Abnormalities in Moderate-Severe Asthma

Abstract

BACKGROUNDAsthma is recognized as an inflammatory disease of the airways, but inflammation may also affect the parenchyma and pulmonary vasculature. Hyperpolarized129Xe MRI and MR spectroscopy (MRS) provide a way to quantify the transfer of gas from the airways through the alveolar membrane and its binding to hemoglobin in the red blood cells (RBC) of the pulmonary microvasculature. The vast majority of129Xe MRS studies have investigated interstitial lung disease and the ratio of129Xe binding to the RBC and129Xe present in the alveolar membrane, (RBC:membrane) which is a surrogate of oxygen gas-transfer to the blood. We wondered if129Xe RBC:membrane would differ in asthma patients as compared to healthy volunteers because of recent work showing abnormally diminished pulmonary vascular small-vessel structure in severe-asthma.RESEARCH QUESTIONDo129Xe MRI gas-transfer measurements differ significantly in patients with moderate-severe asthma?STUDY DESIGN AND METHODSIn this retrospective study, healthy (NCT02484885) and asthma (NCT04651777;NCT02351141) participants were evaluated who provided written informed consent.RESULTSThirty-one participants with asthma (mean age=55 years ±18; 22 females) and 32 healthy volunteers (mean age=31 years ±14; 12 females) with129Xe MRS were evaluated. FEV1, VDP and DLCO/KCOwere significantly different in asthma compared to healthy participants. Age-corrected1RBC:membrane was significantly different in moderate-severe asthma (0.32±0.09) as compared to healthy participants (0.47±0.12,P=.01). RBC:membrane was significantly related to pulse-oximetry hemoglobin estimates (ρ=.29;P=.04) and DLCO(ρ=.71;P<.001). Significant relationships between129Xe RBC:membrane and age were observed in healthy (ρ=-.55;P=.002) and asthma participants (ρ=-0.49;P=.006), adjusted for sex. A significant ANCOVA model also revealed the influence of age (P=.002), sex (P<.001), hemoglobin (P=.003) and asthma status (P=.02) on RBC:membrane.INTERPRETATION129Xe RBC:membrane values were significantly different in moderate-severe asthma compared to healthy volunteers and were explained by age, sex, hemoglobin, and asthma status.