Pulmonary Surfactant and Its Relationship to the Alveolar Epithelial Cell

Sun, Chao; Mendenhall, R. M.

doi:10.1508/cytologia.30.465

Cited by 2 publications

(2 citation statements)

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“…(1968) that the lameHated bDdies are direct transfDrmations Df mitochondria, but this view has nDt met with general acc~ptance (Campiche et aI. 1963, Matasa & Nakamura 1965, Sun & Mendenhall 1965, Goldfischer et al 1968). Other authors cDnsidered the osmiDphilic lamellated bodies to arise by trans-fDrmatiDn of multives~cular bDdies (Hatasa & Nakamura 1965, SDrDkin 1966, Kuhn 1968, Goldenberg et al 1969.…”

Section: Introductionmentioning

confidence: 99%

“…OsmiDphilic lamellated bodies were prDpDsed as the mDrphologica'i correlates Df pulmonary surfactant by Buckingham & Avery (1962), Bensch et al (1%4), and Mendenhall & Sun (1964), and were interpreted as secretory organelles by a number of authDrs. At the same time, the osmiophilic lamellated material was recDgnised as membranDus (Balis & Conen 1964, Mendenhall & Sun 1964, Sun & Mendenhall 1965, LeesDn & LeesDn 1966, Smith et aI. 1972, DiAugustrne 1974, WHliams 1977, Sanderson & Vatter 1977.…”

Section: Introductionmentioning

confidence: 99%

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The alveolar epithelium of the newborn rat, and the significance of the osmiophilic lamellated bodies in cellular autophagy

Williams

1981

New Zealand Journal of Zoology

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An attempt was made to deltermine the nature, origin, and fate of the membrane material of osmiophrlic lamella ted bodies, using lung tissue from neonate rats. The cytDplasm of the type II alveDlar pneumDnocyte contains ce!lItrioles, multivesicular bodies, and minute free vesicles similar to' those in the multivesicular bDdies. AutolysDsDmes, comprising membrane-bDunded cytoplasmic regiDns and osmiDphilic lamellated material, alsO' DC:::tlr in the type II pneumDnocytes. The mitochDndria often cDntain concentric membrane accumulatiDns and membranous whorls. The type II alveolar cells are chaf'dl::terised by an intensive autophagy; this isapparentIy correlated with glycDgenolysis, and with a radical cytodifferentiatiDn by which the cells transform to the type I pneumDnocyte. The osmiDphilic lamellae Df the autDlysowmes are proba:bly emptied isolation membranes. The mitochDndria poss~bly serve as repositories for the mass,ive membrane a,ccumulatiDns remaining after cytDplasmil:: lysis, which may invaginate intO' the organelles. The osmiophilic lamellated bodies typical of type n alveolar pneumDnDcytes may be mitochondrial membranes packed with the residual membranous material. Myeloid matter in the alveo'lar spaces (derived frDm the osmiophilic lamellated bDdies) is best interpreted, not as an organised secretory product, but rather as a residue Df cellular autDphagy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The alveolar epithelium of the newborn rat, and the significance of the osmiophilic lamellated bodies in cellular autophagy

Williams

1981

New Zealand Journal of Zoology

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Formation of Lamellar Bodies in Schwann Cell Cytoplasm Induced by Alcohol Injury

Sun¹,

White²,

Flanigan³

1972

Proc. annu. meet. Electron Microsc. Soc. Am.

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The presence of lamellar bodies in the Schwann cell has been encountered in several occasions. This presentation deals with lamellar bodies which occur in the Schwann cell of patients treated with 0.8 cc absolute ethanol intrathecal injection for relief of pain. Biopsies of nerve roots in the region of injection were taken from patients, 2 days and 5 days after ethanol treatment. Two days after alcohol injection, the myelin sheath of the axon in the Schwann cells was disrupted; in many cases, a complete destruction of the myelin system was seen (Fig. 1). By the 5th day after treatment, apparently less destruction was seen and we are led to assume that the damaged axons recovered through a process of remyelinization, although focal degeneration of the myelin sheath and lamellar bodies still remained.

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Pulmonary Surfactant and Its Relationship to the Alveolar Epithelial Cell

Cited by 2 publications

References 5 publications

The alveolar epithelium of the newborn rat, and the significance of the osmiophilic lamellated bodies in cellular autophagy

The alveolar epithelium of the newborn rat, and the significance of the osmiophilic lamellated bodies in cellular autophagy

Formation of Lamellar Bodies in Schwann Cell Cytoplasm Induced by Alcohol Injury

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