Pulmonary Toxicity Caused by Cytotoxic Drugs

Roig, Jorge; Domingo, Christian; Gea, Elvira

doi:10.1097/01.cpm.0000197361.07900.51

Cited by 8 publications

(6 citation statements)

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“…First we undertook a large-scale review of pulmonary toxicity caused by cytotoxic drugs [ 2 ] and selected the chemotherapeutic drugs responsible for respiratory disturbances not related to their cytotoxic effect. We then reviewed the different non-cytotoxic drugs currently used to treat malignancies, and selected those with potential lung toxicity.…”

Section: Methodsmentioning

confidence: 99%

“…Lung toxicity related to this tyrosine kinase activity inhibitor is very uncommon and usually mild [ 70 ]. Worldwide, the incidence of interstitial lung disease is <1% [ 2 ]. However, severe pulmonary reactions have also been reported [ 71 ].…”

Section: Pulmonary Toxicity Due To Non-cytotoxic Drugs Used To Treat mentioning

confidence: 99%

“…Since the first report of a link between busulfan and pulmonary toxicity was published in 1961 [ 1 ], the literature on lung disease induced by cytotoxic drugs has grown steadily [ 2 ]. As the number of drugs used in cancer chemotherapy increases, the incidence of pulmonary toxic effects may rise even further, especially since patients with cancer now survive longer and their lung cell populations are exposed to cytotoxic agents for longer periods of time.…”

Section: Introductionmentioning

confidence: 99%

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Neglected Respiratory Toxicity Caused by Cancer Therapy

Domingo¹,

Roig²

2007

TORMJ

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When a patient with lung cancer presents non-specific respiratory symptoms there are many diagnostic options. Chemotherapy is the cornerstone of treatment in many stages of lung cancer and its toxicity is well known. The main priority is to prevent life-threatening diseases such as lung infection, which can be treated successfully if a prompt, accurate diagnosis is given. Drug-induced pulmonary disease must be avoided at all costs but it is also important to avoid sideeffects of drugs which do not directly interfere with respiratory physiology but may impair gas exchange. This review highlights the risks and characteristics of non-cytostatic-induced lung toxicity caused by agents that have been commonly used to treat cancer in recent decades. Physicians should be alert to the possibility of this neglected non-chemotherapyinduced lung toxicity in cancer patients, since early withdrawal of the offending drug is mandatory.

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Section: Methodsmentioning

confidence: 99%

Section: Pulmonary Toxicity Due To Non-cytotoxic Drugs Used To Treat mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neglected Respiratory Toxicity Caused by Cancer Therapy

Domingo¹,

Roig²

2007

TORMJ

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“…43 Approximately 1-10% of the patients will be affected by taking one of these drugs. The primary mechanism of injury involved is by free radicals on the endothelium leading to necrosis of pneumocytes.…”

Section: Toxic Lung Injurymentioning

confidence: 99%

Oncologic emergencies: a review

Baruah

2018

Int J Res Med Sci

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Cancer and its treatment include many medical emergencies. Hence taking care of these emergencies presents a challenge not only to the clinicians but also to the medical oncologists. Cancer patients may have complex medical problems in addition to cancer such as coronary heart diseases, diabetes mellitus, and respiratory diseases. Such patients require immediate medical assistance and emergency care facilities to improvise their health condition. The present review paper focuses on more commonly confronted emergencies in cancer patients and their related management.Keywords: Hyperviscosity syndrome, Hemostatic emergencies, Oncologic emergencies, Tumor lysis syndrome, SIADH DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20181492Baruah M. Int J Res Med Sci. 2018 May;6(5):1484-1490 International Tumor lysis syndrome (TLS)TLS results from destruction of large number of rapidly multiplying cells as a result of cancer induction chemotherapy but can also be seen after treatment with radiotherapy, corticosteroids, and hormonal agents such as tamoxifen, biological agents such as Interferon or spontaneously in patients with high tumor burden. This syndrome is associated with severe electrolyte abnormalities, hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, lactic acidosis and can lead to acute renal failure. 5 No specific signs and symptoms are noted for this syndrome. Symptoms may advance in line with electrolyte disturbances that include muscle weakness, arrhythmias, neuromuscular irritability, seizures and sudden death. 6 The main cause of mortality in these patients was arrhythmia associated with electrolyte disturbances, predominantly hyperkalemia and renal failure. 7 Hence, careful assessment, monitoring and treating related electrolyte disturbance is very essential to avoid serious complications of this syndrome.Regular monitoring of electrolytes, BUN, creatinine, uric acid, phosphates and calcium levels forms the basis of therapy. Patients should be well hydrated (200-300ml/hr). Urinary flow should be increased by diuretics such as Mannitol. Sodium bicarbonate 100mEq/l should be given for urinary alkalization, Allopurinol 500 mgm/m 2 on day 1 to day 3 then reduced to 200mgm/m2 throughout cytoreductive therapy.8 Calcium therapy and exchange resins for hyperkalemia may be considered. Calcitrol therapy may be considered for persistently low Calcium levels.9 SIADH SIADH, characterized by hyponatremia that occurs due to the production of arginine vasopressin by the tumour cells. Hyponatremia is related with plasma hyposmolarity and high urinary osmolarity, together with a high level of elimination of urinary sodium without any change in plasma volume. 6 Other reasons may include use of some drugs like ACE inhibitors, antidepressants, and antimitotics such as cyclophosphamide, vincristine, cisplatin, melphalan and even some surgical procedures and due to some tumours like small-cell lung cancer. 10Most of the patients are asymptomatic. Early symptoms include anorexia, irritability, depression, musc...

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“…Поздние признаки, обнаруживаемые спустя ≥ 2 мес. после за вершения химиотерапии, регистрируются, как пра вило, в виде фиброза [3,5].…”

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