Pulmonary Toxicity of Cytotoxic and Immunosuppressive Agents: A Review

Lehne, Gustav; Lote, Knut

doi:10.3109/02841869009126530

Cited by 32 publications

(18 citation statements)

References 133 publications

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“…Clinical experience with bleomycin in elderly patients has taught that this drug may be associated with a high-risk of pulmonary complications, in particular if prior mediastinal irradiation has been applied (Lehne and Lote, 1984). Wettlaufer (1984) has designed a combination drug schedule in which bleomycin is replaced by vincristine, a drug with minimal bone marrow toxicity.…”

Section: Resultsmentioning

confidence: 99%

Cisplatin, vincristine and ifosphamide combination chemotherapy of metastatic seminoma: results of EORTC trial 30874

et al. 1995

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S_ury 1The aims of the trial were to estabish the response rate and determine the toxxity of combination chemotherapy with ifospamide, vincristine and spatin (HOP regimn) in advanced metastatic seminoma and to study the role of post-chemotherapy consdation treatment Patients with bulky metasatic non-sfetoprotein-producing seminos were eligible for this phase II study [serum human chorionic gonadotropin<20OUI1' (<40ng1-')] if they pested with abdomial masses > 10cm or had extra-gonadal seminoma or had relapsed after previous radiotherapy. The HOP regimen consisted of four 3-weekly cycles of the following drug combination ifosphamide (days 1-5, 1 2mg m2 day-'), vincristin (day 1, 2mg) and cisplatin (days 1-5, 20mgm-2 day-'). Residual masses persisting 6 months after chemotherapy could be considered for consolidation surgery or radiotherapy.

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Section: Resultsmentioning

confidence: 99%

Cisplatin, vincristine and ifosphamide combination chemotherapy of metastatic seminoma: results of EORTC trial 30874

et al. 1995

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“…Indeed, scouring powder (Ajax) contains up to 95% silica, 2% alkylbenzosulphonate and 3% trichlorocyanuric acid (personal communication of Colgate Palmolive, France). Alveolar proteinosis caused by chemical agents, such as busulfan and carmustine has been reported [15], but never by those additives which are present at low concentration in scouring powder.…”

Section: Discussionmentioning

confidence: 99%

Connective tissue disease due to intentional inhalation of scouring powder

Vincent

Pouchelle²,

Martiñón³

et al. 1996

Eur Respir J

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C Co on nn ne ec ct ti iv ve e t ti is ss su ue e d di is se ea as se e d du ue e t to o i in nt teWe report the case of a young woman who developed Sharp' 's syndrome 5 yrs after diagnosis of acute silicosis due to scouring powder inhalation. The frequency of diseases from scouring powder as well as physiopathological and therapeutical issues of the associatition of pneumoconiosis and connective tissue disease are discussed.

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“…Crackles are frequently audible in the lower lung fields and may reflect diffuse or mixed interstitial and alveolar infiltration. Radiographically there are bilateral opacities, usually at the mid-lower zones of the lungs [12,13] . The criteria for FAPT are dyspnea, fever, hypoxemia, radiographic infiltrates in a patient treated with fludarabine and the exclusion of infection.…”

Section: Discussionmentioning

confidence: 99%

Severe Pulmonary Toxicity Associated with Fludarabine and Possible Contribution of Rituximab

et al. 2010

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Fludarabine is a nucleoside analogue used in the treatment of low-grade lymphoproliferative disorders and in conditioning regimens of non-myeloablative allogeneic stem cell transplantation. This is a relatively safe drug for clinical use but may cause side effects, some of which may be life-threatening. Here a case of severe pulmonary toxicity associated with fludarabine and a possible contribution of rituximab is presented and the literature reviewed.

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Pulmonary Toxicity of Cytotoxic and Immunosuppressive Agents: A Review

Cited by 32 publications

References 133 publications

Cisplatin, vincristine and ifosphamide combination chemotherapy of metastatic seminoma: results of EORTC trial 30874

Cisplatin, vincristine and ifosphamide combination chemotherapy of metastatic seminoma: results of EORTC trial 30874

Connective tissue disease due to intentional inhalation of scouring powder

Severe Pulmonary Toxicity Associated with Fludarabine and Possible Contribution of Rituximab

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