Pulmonary Tuberculosis Associated with Carcinoma of the Lung

Christoforidis, Anthimos J.

doi:10.1001/archinte.1959.00270020059007

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Subsequent attempts to relate these two diseases aetiologically varied from marked incompatibility or antagonism (Rokitansky, 1854;Pearl, 1929;Cooper, 1932) to a direct cause and effect relationship (McConkey, 1908;Ewing, 1928;Fried, 1935;Cohen, 1949;Woodruff et al, 1951 and1952;Hauser and Glazer, 1955;Bender, 1956;Finke, 1956;Weissman, 1956;Jackson, Garber, and Post, 1957;Wofford, Webb, and Stauss, 1962;Gebel, Epstein, Fulkerson, and Sparger, 1962). Several studies reported in the recent past logically speculated on purely circumstantial or fortuitous coexistence, i.e., the increasing association of the two diseases is due to adequate treatment, improved diagnostic methods, changes in the epidemiology, and increasing life expectancy (Bergmann, Shatz, and Flance, 1948;Shefts and Hentel, 1950;Carey and Greer, 1958;White, Beck, and Pecora, 1959;Christoforidis and Browning, 1959;Fontenelle and Campbell, 1970).…”

mentioning

confidence: 99%

Concurrent pulmonary tuberculosis and primary carcinoma

Berroya¹,

Polk²,

Raju³

et al. 1971

Thorax

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mentioning

confidence: 99%

Concurrent pulmonary tuberculosis and primary carcinoma

Berroya¹,

Polk²,

Raju³

et al. 1971

Thorax

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Tuberculosis and Nontuberculous Mycobacterial Infections

Tomashefski

Farver

2008

Dail and Hammar’s Pulmonary Pathology

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Macrophages are needed in the progression of tuberculosis into lung cancer

et al. 2015

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Although the association of tuberculosis (TB) and the development of lung carcinoma (LC) has been acknowledged, the underlying mechanism remains not clarified. Since sustained and repeated local inflammation and tissue remodeling have been suggested to be responsible for the high incidence of developing CL from TB, we hypothesize that macrophages may play a critical role in the process. To prove it, we induced TB in mice by injection of virulent Mycobacterium tuberculosis (MTB). Then the mice were allotted into two groups. One group received weekly tail vein injection of 20 μg saporin-conjugated antibody against the pan-macrophage surface marker CD11b to eliminate macrophages, while the other group received injection of control IgG in the same frequency. Six months later, the development of LC was determined by histology. We found that the occurrence of LC in TB mice that received macrophage depletion was significantly lower than those in control TB mice without macrophage intervention. These data suggest that macrophages may promote the progression of TB into LC.

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Pulmonary Tuberculosis Associated with Carcinoma of the Lung

Cited by 6 publications

References 7 publications

Concurrent pulmonary tuberculosis and primary carcinoma

Concurrent pulmonary tuberculosis and primary carcinoma

Tuberculosis and Nontuberculous Mycobacterial Infections

Macrophages are needed in the progression of tuberculosis into lung cancer

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