Pulmonary tuberculosis: comparison of CT findings in HIV-seropositive and HIV-seronegative patients.

Leung, Ann N.; Brauner, M.; Gamsu, G; Mlika-Cabanne, N; Romdhane, H; Carette, M.F.; Grenier, P.

doi:10.1148/radiology.198.3.8628855

Cited by 107 publications

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“…Such findings were similar to those observed in the present study that also demonstrated agreement with studies developed by Leung et al (26) , which have demonstrated that HIVpositive patients present low prevalence of cavities and high prevalence of lymph node enlargement.…”

Section: Discussionsupporting

confidence: 94%

“…The study developed by Leung et al (26) suggests that, in HIV-positive patients, atypical opacities with involvement of the middle and lower lobes may be secondary to the bronchogenic dissemination of the disease. According to these authors, atypical opacities were the most frequent finding in the HIV/tuberculosis association, with bronchogenic dissemination in 57% and miliary dissemination, in 17% of patients.…”

Section: Discussionmentioning

confidence: 99%

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Aspectos tomográficos da tuberculose pulmonar em pacientes adultos com AIDS

et al. 2011

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Objective: The present study is aimed at describing computed tomography findings pulmonary tuberculosis in adult AIDS patients assisted at a radiology unit of a reference infectious diseases hospital, in an attempt to establish the association between such findings and CD4 count. Materials and Methods: Forty-five patients were evaluated by chest computed tomography over a four-year period. Results: Mediastinal and/or hilar lymph node enlargement was found in 31 (68.8%) cases, pleural effusion in 29 (64.4%), centrilobular nodules with segmental distribution in 26 (57.7%), consolidation in 24 (53.3%), confluent micronodules in 17 (37.7%), poorly defined nodules with centrilobular distribution in 16 (35.5%), tree-in-bud pattern in 13 (28.9%), bronchial wall thickening in 12 (26.6%), thick-walled cavity in 10 (22.2%), miliary nodules in 9 (20%), and cylindrical bronchiectasis in 6 (13.3%). Among the 45 patients, 35 (77.8%) presented CD4 count < 200 cel/mm 3 and 10 (22.2%) presented CD4 count ≥ 200 cel/mm 3 . Conclusion: Differently from reports in the literature, the authors conclude that mediastinal and/or hilar lymph node enlargement and consolidation were significantly most frequent in patients with CD4 count ≥ 200 cel/mm 3 . However, lymph nodes with hypodense center were most often observed in severely immunosuppressed patients with CD4 count < 200 cel/mm 3 . Keywords: Tuberculosis; Tomography; Chest; HIV; AIDS; SIDA.Objetivo: Este trabalho tem como finalidade descrever os achados tomográficos da tuberculose pulmonar em pacientes adultos com AIDS atendidos no serviço de radiologia de um hospital de referência em doenças infecciosas, procurar associações desses achados e a contagem de CD4. Materiais e Métodos: Foram estudados 45 pacientes por meio de tomografia computadorizada de tórax durante quatro anos. Resultados: Foram encontrados linfonodomegalia mediastinal e/ou hilar em 31 (68,8%) dos casos, derrame pleural em 29 (64,4%), nódulos centrolobulares de distribuição segmentar em 26 (57,7%), consolidação em 24 (53,3%), confluência de micronódulos em 17 (37,7%), nódulos mal definidos com distribuição centrolobular em 16 (35,5%), padrão de "árvore em brotamento" em 13 (28,9%), espessamento de parede brônquica em 12 (26,6%), cavidade de parede espessa em 10 (22,2%), nódulos miliares em 9 (20%) e bronquiectasias cilíndricas em 6 (13,3%). Dos 45 pacientes, 35 (77,8%) apresentaram CD4 < 200 cel/mm 3 e 10 (22,2%) apresentaram CD4 ≥ 200 cel/mm 3 . Conclusão: Concluímos que neste estudo, diversamente do descrito na literatura, linfonodomegalia mediastinal e/ou hilar e consolidação foram significativamente mais frequentes em pacientes com CD4 ≥ 200 cel/mm 3 . No entanto, linfonodos com centro hipodenso foram mais frequentemente observados em pacientes com severa imunodepressão, ou seja, CD4 < 200 cel/mm 3 . Unitermos: Tuberculose; Tomografia; Tórax; HIV; AIDS; SIDA. AbstractResumo

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Aspectos tomográficos da tuberculose pulmonar em pacientes adultos com AIDS

et al. 2011

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“…The patients included in the study were those that were referred to the specialist unit for management and were likely to have more complicated disease and therefore more obvious imaging findings. In patients who were HIV positive there was a lower prevalence of parenchymal consolidation, cavitation and post-primary pattern, and a higher prevalence of extrapulmonary and miliary disease than in those who were HIV negative [18,19], but this imaging pattern was not demonstrated in this study. Notably, the incidence of mycetoma was equally likely amongst HIV-positive and HIV-negative cases.…”

Section: Discussioncontrasting

confidence: 68%

The impact of coinfection with human immunodeficiency virus and pulmonary tuberculosis on the success of bronchial artery embolisation

Govind

Maharajh²

2013

BJR

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“…As the CD4 cell count declines, the frequency of cavitation in pulmonary TB decreases. Data were pooled from 12 studies (6,19,34,66,71,105,143,144,159,199,208,210) that examined the frequency of lung cavitation associated with CD4 counts in patients coinfected with HIV and pulmonary TB. Patients whose CD4 count was above 200 cells/l had a 4-fold-higher odds of having cavitary pulmonary TB than those with CD4 counts below 200 cells/l (odds ratio, 4.44; 95% CI, 3.36, 5.88).…”

Section: Effect Of Hiv On Tuberculosis: Atypical Presentation and Extmentioning

confidence: 99%

HIV and Tuberculosis: a Deadly Human Syndemic

2011

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SUMMARY A syndemic is defined as the convergence of two or more diseases that act synergistically to magnify the burden of disease. The intersection and syndemic interaction between the human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have had deadly consequences around the world. Without adequate control of the TB-HIV syndemic, the long-term TB elimination target set for 2050 will not be reached. There is an urgent need for additional resources and novel approaches for the diagnosis, treatment, and prevention of both HIV and TB. Moreover, multidisciplinary approaches that consider HIV and TB together, rather than as separate problems and diseases, will be necessary to prevent further worsening of the HIV-TB syndemic. This review examines current knowledge of the state and impact of the HIV-TB syndemic and reviews the epidemiological, clinical, cellular, and molecular interactions between HIV and TB.

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Pulmonary tuberculosis: comparison of CT findings in HIV-seropositive and HIV-seronegative patients.

Abstract: HIV-seropositive patients had a lower prevalence of localized parenchymal disease and a higher prevalence of disseminated disease at CT.

Cited by 107 publications

References 0 publications

Aspectos tomográficos da tuberculose pulmonar em pacientes adultos com AIDS

Aspectos tomográficos da tuberculose pulmonar em pacientes adultos com AIDS

The impact of coinfection with human immunodeficiency virus and pulmonary tuberculosis on the success of bronchial artery embolisation

HIV and Tuberculosis: a Deadly Human Syndemic

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