Pulmonary Vascular Disease in the Developing World

Butrous, Ghazwan; Ghofrani, Hossein Ardeschir; Grimminger, Friedrich

doi:10.1161/circulationaha.107.727289

Cited by 100 publications

(101 citation statements)

References 82 publications

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“…Schistosomal pulmonary hypertension is diagnosed in approximately 10% of the patients with hepatosplenic schistosomiasis [48][49][50][51] ; the use of pulmonary vasodilators has greatly improved the survival and quality of life of those patients [52][53][54][55] .…”

Section: Complications Of Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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Section: Complications Of Hepatosplenic Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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“…Schistosomiasis is the third leading cause of endemic parasitic diseases worldwide, with more than 300 million infected individuals and approximately 600 million at risk of infection 4 . Prevalence rates between 7.5% and 21.6% of pulmonary hypertension have been reported in endemic areas, in individuals with schistosomiasis, which can reach up to 30% in the hepatosplenic forms and most described cases being classified as moderate or severe with advanced functional class 4,5 .…”

Section: Introductionmentioning

confidence: 99%

“…Prevalence rates between 7.5% and 21.6% of pulmonary hypertension have been reported in endemic areas, in individuals with schistosomiasis, which can reach up to 30% in the hepatosplenic forms and most described cases being classified as moderate or severe with advanced functional class 4,5 . In an autopsy-based study, cor pulmonale was detected in approximately 2.1% -33% of cases 6 .…”

Section: Introductionmentioning

confidence: 99%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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“…José Roberto Lambertucci [1] , Eduardo Belisário Falcheto [2] and Vinicius Alves Lara Santos [2] [1]. A 58-year-old female patient was admitted to hospital with a history of dyspneia, cough and chest pain which started one year before the present admission.…”

Section: Dilated Paraumbilical Vein In Hepatosplenic Schistosomiasis mentioning

confidence: 99%

Dilated paraumbilical vein in hepatosplenic schistosomiasis associated with pulmonary hypertension

Lambertucci

Falcheto

Santos

2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(6):797, Nov-Dec, 2013http://dx.doi. org/10.1590/0037-8682-0193-2013 Dilated paraumbilical vein in hepatosplenic schistosomiasis associated with pulmonary hypertension A 58-year-old female patient was admitted to hospital with a history of dyspneia, cough and chest pain which started one year before the present admission. In the last 15 days she noticed worsening of her previous symptoms. There was also peripheral edema, tachycardia and palpitation with limitation corresponding to functional class IV (World Health Organization). She came from an area endemic for schistosomiasis and had the hepatosplenic form of the disease. She was also obese. Abominal ultrasound confirmed the diagnosis of periportal fi brosis and portal hypertension. Chest X-ray showed a prominent fourth arch (Figure A: white arrow). Right heart catheterization showed a pulmonary artery systolic pressure of 88mmHg and a mean pulmonary pressure of 46mmHg. A computerized tomography of the abdomen with 3D reconstruction showed the presence of a large venous shunt (dilated paraumbilical vein) connecting the portal system to the left iliac vein/inferior vena cava (Figure B). Magnetic resonance A B CREFERENCES imaging of the heart revealed a great dilation of the pulmonary artery (Figure C: short arrow: pulmonary truncus; large arrow: left pulmonary artery; RV: right ventricle). In this case the contribution of the porta-pulmonary shunt to the development of pulmonary hypertension has been suggested as one of the many factors responsible for this complication in hepatosplenic schistosomiasis mansoni.

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Pulmonary Vascular Disease in the Developing World

Cited by 100 publications

References 82 publications

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Dilated paraumbilical vein in hepatosplenic schistosomiasis associated with pulmonary hypertension

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