Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs

Gallinari, Marjorie de Oliveira; Cintra, Luciano Tavares Ângelo; Benetti, Francine; Rahal, Vanessa; Ervolino, Edílson; Briso, André Luiz Fraga

doi:10.1371/journal.pone.0210338

Cited by 20 publications

(28 citation statements)

References 26 publications

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“…Carbamide peroxide was introduced as an alternative to the traditional hydrogen peroxide, and its use has become widespread [7]. Carbamide peroxide is unstable and breaks down immediately upon contact with tissue and saliva, first dissociating into hydrogen peroxide and urea and subsequently into oxygen, water, and carbon dioxide [4,8].…”

Section: Introductionmentioning

confidence: 99%

Effect of dental bleaching on the microhardness and surface roughness of sealed composite resins

et al. 2020

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Objectives: The aim of this in vitro study was to evaluate the microhardness and surface roughness of composite resins before and after tooth bleaching procedures. Materials and Methods: Sixty specimens were prepared of each composite resin (Filtek Supreme XT and Opallis), and BisCover LV surface sealant was applied to half of the specimens. Thirty enamel samples were obtained from the buccal and lingual surfaces of human molars for use as the control group. The surface roughness and microhardness were measured before and after bleaching procedures with 35% hydrogen peroxide or 16% carbamide (n = 10). Data were analyzed using 1-way analysis of variance and the Fisher test (α = 0.05). Results: Neither hydrogen peroxide nor carbamide peroxide treatment significantly altered the hardness of the composite resins, regardless of surface sealant application; however, both treatments significantly decreased the hardness of the tooth samples (p < 0.05). The bleaching did not cause any change in surface roughness, with the exception of the unsealed Opallis composite resin and dental enamel, both of which displayed an increase in surface roughness after bleaching with carbamide peroxide (p < 0.05). Conclusions: The microhardness and surface roughness of enamel and Opallis composite resin were influenced by bleaching procedures.

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Section: Introductionmentioning

confidence: 99%

Effect of dental bleaching on the microhardness and surface roughness of sealed composite resins

et al. 2020

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“…These types of anti‐inflammatory drugs exert their pharmacological effect at the genomic level, either through binding to glucocorticoid recognition elements (GRE) in DNA, inducing the transcription and translation of anti‐inflammatory proteins (Charmandari, 2012) or by suppressing the expression of pro‐inflammatory genes, by inhibiting transcription factors, such as NF‐κB (Biddie et al, 2012), thus avoiding the synthesis of pro‐inflammatory mediators, such as TNF‐α, as well as the expression of COX‐2, with the subsequent inhibition of the synthesis of PGE 2 (Muñoz‐Carrillo et al, 2017a). Various studies have shown that glucocorticoids are effective for the treatment of pulp inflammation (Gallinari et al, 2019), as well as for the reduction of the periapical inflammatory response after endodontic treatment (Holland, 1996; Marshall, 2002). The results agree with that reported in the literature since, in the present study, treatment with dexamethasone significantly decreased (* p < .05) the levels of PGE 2 and TNF‐α at the systemic level, both at 14 and 18 hours, after pulp damage.…”

Section: Discussionmentioning

confidence: 99%

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

et al. 2021

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Aim To evaluate whether treatment with resiniferatoxin (RTX) is capable of lowering the plasma levels of PGE2 and TNF‐α, as well as histopathological parameters in inflammation of pulp tissue in a mouse experimental model. Methodology Ten groups of six BALB/c mice were formed as follows: healthy group (HC), healthy group treated with RTX (HRTX), two groups with pulp inflammation at 14 and 18 hours (PI14/PI18), six groups with pulpal inflammation plus treatment with Ibuprofen (IBU14/IBU18), dexamethasone (DEX14/DEX18) and resiniferatoxin (RTX14/RTX18) at 14 and 18 hours, respectively. Pulpal inflammation was induced through occlusal exposure of the pulp of the maxillary first molar. The plasma levels of PGE2 and TNF‐α and the histological parameters of the pulp tissue of the HC and HRTX groups were evaluated at the time of acquiring the animals. In the other groups, the plasma levels of PGE2 and TNF‐α and the histopathological parameters were evaluated at 14 and 18 hours after pulp damage. Plasma levels of PGE2 and TNF‐α were quantified by ELISA, and the histopathological parameters were evaluated by H/E staining. Statistical significance was determined by one‐way analysis of variance (ANOVA) to test for overall differences between group means. Results A significant increase (*p < .05) in plasma levels of PGE2 and TNF‐α occurred 14 and 18 hours after pulp damage. In addition, treatment with RTX significantly decreased (*p < .05) the plasma levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage, as well as the infiltrate of inflammatory cells at 18 hours after pulp damage, similarly to treatment with ibuprofen and dexamethasone. Conclusion It was possible to detect systemic levels of PGE2 and TNF‐α at 14 and 18 hours after pulp damage. Likewise, treatment with RTX was associated with an anti‐inflammatory effect similar to treatment with ibuprofen and dexamethasone. These findings place resiniferatoxin as a therapeutic alternative in the treatment of inflammatory diseases in Dentistry.

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“…The pulp necrosis caused in this way is the state of dying cell elements of the pulp due to the ichemy, and should be differentiatd from the pup gangrene which is dominantely accompanied by the direct toxic and necrotic effect of the microorganism. It follows from this that anti-inflammatory therapy is completely sufficient and even causal in this case.That is, by stopping the inflammation, the whole cascade of unwanted events which can potentially be caused by the teeth bleaching (20)(21).…”

Section: The Teeth Bleaching Effects and The Biological Response Of T...mentioning

confidence: 99%

“…Scientists have come up with the solution of this problem by measuring and following the level of specific protein molecules which are released during the inflammatory process and are in the direct connection with the promotion of the pain sensation. These are the substance P and the calcitonin related peptide (CGRP -calcitonin gene-related peptide) (20)(21).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Different Drugs with Anti-Inflamatory Potential in Prevention of Pulp Damage During the Teeth Bleaching

Glisic

Milojevic

Milinković

et al. 2023

Experimental and Applied Biomedical Research (EABR)

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This paper aims to collect all the necessary information and conclusions which deal with the anti-inflammatory drugs within the scope of teeth bleaching, and which are rooted in scientific research. It is a well-known fact that the teeth whiteners / bleachers are at the same time a very aggressive agents, which opened up the question of the safety of their application. The most frequently applied bleaching agents are the hydrogen-peroxide (H2O2) and carbim peroxide (CH6N2O3), therefore this paper will be based on the research which included these two agents. The first studies were directed towards investigating the outcome / impact on the enamel, i.e. if there is direct surface damage of the enamel layer after the use of such agents. However, bearing in mind that the clinical practice has shown that in a number of cases there arises the sensitivity of teeth in the form of painful sensation after the bleaching treatment, some researches were directed towards the estimation of the permeability of the enamel and dentin for the bleaching agent, and later the effect on the pulp tissue. Along with the existing proof about the irritability of these agents to the pulp tissue, the modern research have the idea of looking into the effects of the anti-inflamatory drugs as the accompanying and prevention therapy of any of the irreversible damage of the pulp. On one hand the application of these drugs can reduce the sensitivity and painfulness of the teeth, which makes the intervention pleasant for the patient, but on the other hand the intervention becomes completely justifiable from the aspect of safety and the basic principle primum non nocere. The anti-inflammatory drugs which will be the topic of this study are H hydrocortisone, acetaminophen, ipobruphen and etodolac. Taking into consideration the vasoconstrictive and anti-oxidative effect, the anti-inflammatory effect of the carvedilol will be looked into, which belongs to the group of beta blockers. Based on available informations it can be noticed that the most efficient anti-inflammatory effect in teeth whitening is achived by hydrocortisone.

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Pulp response of rats submitted to bleaching and the use of different anti-inflammatory drugs

Cited by 20 publications

References 26 publications

Effect of dental bleaching on the microhardness and surface roughness of sealed composite resins

Effect of dental bleaching on the microhardness and surface roughness of sealed composite resins

Effect of treatment with resiniferatoxin in an experimental model of pulpal inflammatory in mice

The Effects of Different Drugs with Anti-Inflamatory Potential in Prevention of Pulp Damage During the Teeth Bleaching

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