Pulp Revascularization on Permanent Teeth with Open Apices in a Middle-aged Patient

Wang, Yu; Zhu, Xiaofei; Zhang, Chengfei

doi:10.1016/j.joen.2015.04.022

Cited by 40 publications

(25 citation statements)

References 38 publications

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“…, Wang et al . ) and PRF (Torabinejad & Turman , Rudagi & Rudagi , Shivashankar et al . , Keswani & Pandey , Mishra et al .…”

Section: Resultsmentioning

confidence: 99%

“…, Wang et al . ). PRP and PRF possess important differences regarding their properties to deliver growth factors (Mittal & Narang ).…”

Section: Discussionmentioning

confidence: 97%

“…However, when a collagen sponge soaked with PRP was applied over the blood, a slight improvement in periapical healing, apical closure, root wall thickening and root lengthening was observed (Jadhav et al 2013, Conde et al 2016. The utilization of PRP and PRF has been reported more frequently in recent years (2012)(2013)(2014)(2015), and they were feasible adjuncts to obtain clinical success over more than 30 months follow-up (Ray et al 2015, Wang et al 2015. PRP and PRF possess important differences regarding their properties to deliver growth factors (Mittal & Narang 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Alternative strategies to improve the RCR From the selected studies, 17 (22%) applied alternative strategies in an attempt to improve RCR. Thereby, blood venous derivatives, such as PRP (Jadhav et al 2012, 2013, 2014, Guven Polat et al 2014, Nagaveni et al 2015, Narang et al 2015, Wang et al 2015 and PRF (Torabinejad & Turman 2011, Rudagi & Rudagi 2012, Keswani & Pandey 2013, Mishra et al 2013, Jadhav et al 2015, Nagaveni et al 2015, Narang et al 2015, Ray et al 2015, Solomon et al 2015, Yadav et al 2015, were the most commonly applied. It was reported that PRP slightly improved the results of periapical healing, dentinal walls thickening, root lengthening (Jadhav et al 2013, Narang et al 2015 and apical closure (Jadhav et al 2013).…”

Section: Histological Features Of the Newly Formed Tissue Inside Rootmentioning

confidence: 99%

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A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

et al. 2016

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The aim of this scoping study was to evaluate the survival rate and nature of tissue formed inside root canals of human immature permanent teeth with necrotic pulps (NIPT) under root canal revascularization (RCR). The search was performed in SciVerse Scopus®, PubMed/MEDLINE, Web of Science®, BIREME and in the grey literature up to November 2015. The keywords were selected using MeSH terms and DECs. Two independent reviewers scrutinized the records obtained considering specific inclusion criteria. The included studies were evaluated in accordance with a modified Arksey and O' Malley's framework. From 375 studies that were evaluated, 75 were included. A total of 367 NIPT were submitted to RCR, from which only 21 needed further endodontic treatment. The weighted mean follow-up time was 17.6 months. The data were derived mainly from case reports (69%) or small case series (15%). NaOCl [0.5-6%] was applied as the disinfecting solution in almost all studies. Triple antibiotic paste was as effective as Ca(OH) as on intracanal medicament. De novo tissue was cementum and poorly mineralized bone positive to bone sialoprotein (BSP) but negative to dentine sialoprotein (DSP). Failures were associated mainly with reinfection of the root canal. The majority of included studies reported a significant increase in both root length and width. However, as most of these data came from case reports, they must be interpreted with care, as most were focused on treatment successes (not failures). Therefore, well-designed randomized controlled trials comparing RCR with available apexification treatments are needed to address this gap in the literature.

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“…, Wang et al . ) and PRF (Torabinejad & Turman , Rudagi & Rudagi , Shivashankar et al . , Keswani & Pandey , Mishra et al .…”

Section: Resultsmentioning

confidence: 99%

“…, Wang et al . ). PRP and PRF possess important differences regarding their properties to deliver growth factors (Mittal & Narang ).…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Histological Features Of the Newly Formed Tissue Inside Rootmentioning

confidence: 99%

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A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

et al. 2016

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“…Regarding the cervical sealing material, grey MTA (GMTA) was employed in 50.8% of the teeth (n=96) (4,(8)(9)(10)(11)16,71,(73)(74)(75)(80)(81)(82)(83)(84)(85)(86), white MTA (6,7,13,14,18,69,70,(76)(77)(78)(87)(88)(89)(90)(91)(92)(93)(94)(95) in 46.0% (n=87), Biodentine (72) in 2,1% (n=04) and Calcium-enriched mixture (CEM) (79) cement in 1% (n=02). Although, it was not a goal of this study to review the means by which dental color was taken, it was noticed that in all the included studies teeth color analysis was performed only by means of visual parameters.…”

Section: Studies Characteristicsmentioning

confidence: 99%

Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review

et al. 2018

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This systematic review aimed to evaluate whether alternative materials to conventional triple antibiotic paste (TAP - metronidazole, ciprofloxacin, and minocycline) and grey mineral trioxide aggregate (GMTA) could avoid tooth discoloration in teeth submitted to Regenerative Endodontic Procedure (REP). It was also investigated if dental bleaching is able to reverse the color of darkened teeth due to REP. The search was conducted in four databases (Medline via PubMed, Scopus, ISI Web of Science and BVS - Virtual health library), following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The retrieved papers were uploaded in the software EndNoteTM and two reviewers independently selected the studies and extracted the data. Only studies in humans (case reports, case series, clinical trials) were included in the review. From 1,122 potentially eligible studies, 83 were selected for full-text analysis, and 38 were included in the review. The included studies were mainly case reports (76.3 %). The studies described a total of 189 teeth submitted to REP. From these, about 54% of teeth presented some degree of discoloration. Most teeth presenting color alteration were treated with TAP, especially when combined with GMTA. Only three studies performed dental bleaching to restore the color of teeth and neither bleaching technique was able to restore the original color of the crowns. The use of alternative materials to TAP and GMTA, such as double antibiotic paste or Ca(OH)2 pastes and white mineral trioxide aggregate or BiodentineTM, reduces the occurrence of tooth discoloration.

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Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm

et al. 2015

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Objectives This study sought to investigate, in-vitro, the effects of a recently developed triple antibiotic paste (TAP)-mimic polymer nanofibrous scaffold against Porphyromonas gingivalis (Pg)-infected dentin biofilm. Materials and Methods Dentin specimens (4×4×1mm3) were prepared from human canines. The specimens were sterilized, inoculated with Pg (ATCC 33277), and incubated for one week to allow for biofilm formation. Infected dentin specimens were exposed for 3 days to the following treatments: antibiotic-free polydioxanone scaffold (PDS, control), PDS+25wt.%TAP (25 mg of each antibiotic [metronidazole, ciprofloxacin, and minocycline] per mL of the PDS polymer solution), or a saturated TAP-based solution (50 mg of each antibiotic per mL of saline solution). In order to serve as the negative control, infected dentin specimens were left untreated (bacteria only). To determine the antimicrobial efficacy of the TAP-mimic scaffold, a colony-forming unit (CFU/mL) (n=10/group) measurement was performed. Furthermore, additional specimens (n=2/group) were prepared to qualitatively study biofilm inhibition via scanning electron microscopy (SEM). Statistics were performed and significance was set at the 5% level. Results Both the TAP-mimic scaffold and the positive control (TAP solution) led to complete bacterial elimination, differing statistically (p<0.05) from the negative control group (bacteria only). No statistical differences were observed for CFU/mL data between antibiotic-free scaffolds (2.7 log10 CFU/mL) and the negative control (5.9 log10 CFU/mL). Conclusions The obtained data revealed significant antimicrobial properties of the novel PDS-based TAP-mimic scaffold against an established Pg-infected dentin biofilm. Clinical relevance Collectively, the data suggest that the proposed nanofibrous scaffold might be used as an alternative to the advocated clinical gold standard (i.e., TAP) for intracanal disinfection prior to regenerative endodontics.

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Pulp Revascularization on Permanent Teeth with Open Apices in a Middle-aged Patient

Cited by 40 publications

References 38 publications

A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

A scoping review of root canal revascularization: relevant aspects for clinical success and tissue formation

Alternative to Avoid Tooth Discoloration after Regenerative Endodontic Procedure: A Systematic Review

Antibacterial TAP-mimic electrospun polymer scaffold: effects on P. gingivalis-infected dentin biofilm

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