Pulpal and periapical tissue responses in conventional and monoinfected gnotobiotic rats

Korzen, Barry H.; Krakow, Alvin Arlen; Green, Daniel B.

doi:10.1016/0030-4220(74)90144-3

Cited by 60 publications

(34 citation statements)

References 62 publications

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“…30 Indeed, the sheer number of microorganisms contained in a root canal system appears to influence the severity of the periapical response. 31,32 However, the non-specific infection hypothesis was partly driven by the inability to identify the variance in the microbiota found in the infected root canal space. The problem with studies on oral infections was that anaerobic culturing was not possible until the late 1960s, 33 and consequently, the facultative taxa were over-estimated in early works on the topic.…”

Section: The Cultivable Root Canal Microbiotamentioning

confidence: 99%

On the dynamics of root canal infections—what we understand and what we don't

Zehnder

Belibasakis

2015

Virulence

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Section: The Cultivable Root Canal Microbiotamentioning

confidence: 99%

On the dynamics of root canal infections—what we understand and what we don't

Zehnder

Belibasakis

2015

Virulence

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“…Its dissolving effect on the smeared layer produced during instrumentation leaves the opem'ng of the dentinal tubules exposed, allowing a deep effect of antiseptic agents and possibly a greater adhesion of tlie filling materials (2,4). It is conceivable that EDTA may have a similar effect on lateral and accessory canals as well, since debris may be present in the opening of these eanals, making chemical del)ridenu'nt and obturation imj^ossible (5,6).…”

mentioning

confidence: 99%

Effect of irrigation solutions on the filling of lateral root canals

Goldberg¹,

Massone²,

Spielberg³

1986

Dental Traumatology

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Goldberg 1' ' , ^4assoneJE, Spielberg C. l'.fleet of irrigation solutions on the filling of lateral root canals. Endod Dent Traumatof 1986; 2: 65 66.Abstract -An in vt'lro study invoh-ing 66 single rooted human teeth was perfbrmed. The teeth were divided into 3 groups: eontrof group, root eanals instrumented and irrigated with distilled water; expcrimenlal group A, root canals instrtimented and irrigated with 15"/,, EDTA; and experimental grou]5 B, root canals instrumented atid irrigated with 5",, soditnn hypochlorite. All canals were fifled with laterally condensed gutta-percha and Diaket"" A. Radiographs were taken mesiodistally and buccolingtially and the number of lateral eanals filled in the various teeth was counted. Ilie group treated with 15"o EDTA sliowed a signifieantfy farger mimber of filled lateral canals than the groups irrigated with distilled water or soditnn ln|)()( hlorite.

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“…Pulpal infections often progress to pulp necrosis and periapical lesion development with periapical bone destruction. The severity of pulpal/periapical inflammation has been directly correlated with the total microbial content within root canals, and with the length of time the periapical tissues were exposed to the infecting microorganisms 1) . Microbial studies of endodontic infections have revealed that gramnegative anaerobic bacteria are the prominent microorganisms 2,3) .…”

Section: ⅰ Introductionmentioning

confidence: 99%