Pulsatile Patterns of Gonadotropin Release in Subjects with and without Ovarian Function

Yen, S. S. C.; Tsai, C. C.; Naftolin, Frederick; Vandenberg, Grant W.; Ajabor, L. N.

doi:10.1210/jcem-34-4-671

Cited by 468 publications

(127 citation statements)

References 0 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…In response to the preceding nocturnal increase in LH secretion, T values in the three boys were highest at 0800 h [T, x (range): 0800 h, 2.1 (0.6-6.1) and 2000-2400 h, 1.6 (0.1-3.9) nglml]. Similarly, E2 in subject 1, a late prepubertal girl, was greatest during the day [E2, 2 (range): 0800-1600 h, 22 (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34) and 2000-2400 h, 10.5 (1 0-1 1) pglml).…”

Section: Resultsmentioning

confidence: 99%

The Effects of Opiate Antagonism on Gonadotropin Secretion in Children and in Women with Hypothalamic Amenorrhea

et al. 1984

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

The Effects of Opiate Antagonism on Gonadotropin Secretion in Children and in Women with Hypothalamic Amenorrhea

et al. 1984

View full text Add to dashboard Cite

“…The pulsatile pattern of LH reflects the pulsatile release of GnRH. For FSH, a pulsatile secretion pattern in blood is hard to detect, presumably due to the longer half-life of 4-6 h of FSH compared with 20-30 min for LH (3,4). In boys, the nocturnal LH increase is associated with a concomitant increase in testosterone, while in girls the highest estradiol increase occurs during the day as a result of delayed response of the ovaries (2,5,6).…”

Section: Introductionmentioning

confidence: 99%

Inducing puberty

Delemarre

Felius

Waal

2008

European Journal of Endocrinology

View full text Add to dashboard Cite

Puberty is the result of increasing pulsatile secretion of the hypothalamic gonadotropin releasing hormone (GnRH), which stimulates the release of gonadotropins and in turn gonadal activity.In general in females, development of secondary sex characteristics due to the activity of the gonadal axis, i.e., the growth of breasts, is the result of exposure to estrogens, while in boys testicular growth is dependent on gonadotropins and virilization on androgens.Hypogonadotropic hypogonadism is a rare disease. More common is the clinical picture of delayed puberty, often associated with a delay of growth and more often familial occurring. Especially, boys are referred because of the delay of growth and puberty. A short course (3-6 months) of androgens may help these boys to overcome the psychosocial repercussions, and during this period an increase in the velocity of height growth and some virilization will occur.Hypogonadotropic hypogonadism may present in a congenital form caused by developmental disorders, some of which are related to a genetic disorder, or secondary to hypothalamic-pituitary dysfunction due to, among others, a cerebral tumor.In hypogonadotropic hypogonadism puberty can be initiated by the use of pulsatile GnRH, gonadotropins, and sex steroids. Sex steroids will induce development of the secondary sex characteristics alone, while combined administration of gonadotropins and GnRH may induce gonadal development including fertility.European Journal of Endocrinology 159 S9-S15

show abstract

“…We chose three different "windows" in the menstrual cycle which have been characterized previously in relation to ovarian steroids, gonadotropin secretion, menstrual symptomatology, and presumed opioid activity. The current view of the hormonal interrelationships in the normal luteal phase is that P in the presence of E 2 acts on the hypothalamus to transiently increase opioid activity, thus inhibiting the frequency of pulsatile GnRH secretion and in turn the pulsatile release of LH (Yen et al, 1972;Backstrom et al, 1982;Filicori et al, 1984;Soules et al, 1984). With the fall in E 2 and P secretion from the aging corpus luteum, opioid exposure is withdrawn, allowing GnRH pulsatile secretion to increase in the days preceding menses (Marshall & Kelch, 1986).…”

Section: Discussionmentioning

confidence: 99%

Pulsatile LH secretion in women with premenstrual syndrome (PMS): Evidence for normal neuroregulation of the menstrual cycle

Reame

Marshall

Kelch

1992

Psychoneuroendocrinology

View full text Add to dashboard Cite

SUMMARYThe premenstrual syndrome (PMS) has been proposed to result from excessive exposure to and/or withdrawal of brain opioid activity during the luteal phase. Because hypothalamic opioids are believed to modulate GnRH secretion, in part under the influence of ovarian steroids, we performed longitudinal studies of gonadotropin and ovarian steroid secretion across ovulatory, symptomatic cycles of 17 PMS patients and 8 normal volunteers. Pulsatile LH secretion was measured every 10 min for 8 hr at times when central opioid activity was expected to be low (early follicular phase), high (mid-luteal phase; ML), and declining (late luteal phase). In both subject groups, a cycle-phase effect was observed for LH pulse frequency (p =<0.001) and amplitude (p =0.002), and for the transverse mean concentrations of LH (p =0.05), FSH (p <= 0.001), estradiol (E2) (p=<0.001) and progesterone (P) (p =<0.001). ML P secretion in PMS patients was pulsatile, and mean concentrations (over 30-60 min) were similar to those of normal controls. The changes in pulsatile LH secretion across the cycle were not different in the PMS patients compared to the normal women, though mean FSH in the ML phase was higher in the PMS group (p =<0.05). The similar changes in luteal LH pulse frequency fail to provide evidence that GnRH secretion is impaired, thus challenging the view that the neuroregulation of the menstrual cycle in women with PMS is markedly altered.

show abstract

Pulsatile Patterns of Gonadotropin Release in Subjects with and without Ovarian Function

Cited by 468 publications

References 0 publications

The Effects of Opiate Antagonism on Gonadotropin Secretion in Children and in Women with Hypothalamic Amenorrhea

The Effects of Opiate Antagonism on Gonadotropin Secretion in Children and in Women with Hypothalamic Amenorrhea

Inducing puberty

Pulsatile LH secretion in women with premenstrual syndrome (PMS): Evidence for normal neuroregulation of the menstrual cycle

Contact Info

Product

Resources

About