Pulsatiles Oxytocin zur Auslösung der Wehentätigkeit nach vorzeitigem Blasensprung

Auner, Holger W.; Adelwöhrer, N. E.; Semmelrock, H. J.; Lorenz-Eberhardt, G.; Haas, J.; Gruböck, K

doi:10.1159/000272250

Cited by 2 publications

(3 citation statements)

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“…Fifteen trials compared different regimens of oxytocin (Blakemore 1990; Crane 1993; Daniel-Spiegel 2004; Goni 1995; Hourvitz 1996; Lazor 1993; Lowensohn 1990; Merrill 1999; Morrison 1992; Muller 1992; Parpas 1995; Ross 1998; Satin 1991; Satin 1994; Singh 1993). Eleven trials compared pulsed with continuous delivery systems for oxytocin (Arulkumaran 1985; Ashworth 1988; Auner 1993; Cummiskey 1990; Dawood 1995; Gibb 1985; Odem 1988; Raymond 1989; Salamalekis 2000; Shennan 2006; Willcourt 1994). Twenty trials did not focus on the selected study interventions, did not report any results, or did not have any prespecified outcomes in an extractable format (Anderson 1971; Atad 1999; Blackburn 1973; Bremme 1980; Chestnut 1994; De Leon Casasola 1993; Dietl 1987; Fuchs 2006; Gloeb 1989; Knox 1979; Leszczynska-Gorzelak 1993; MacLennan 1988; Mokgokong 1974; Moise 1991; Mollo 1991; Morgan-Ortiz 2002; Perales 1994; Rees 1991; Vernant 1993; Welt 1987).…”

Section: Resultsmentioning

confidence: 99%

“…Eleven trials compared pulsed with continuous delivery systems for oxytocin (Arulkumaran 1985; Ashworth 1988; Auner 1993; Cummiskey 1990; Dawood 1995; Gibb 1985; Odem 1988; Raymond 1989; Salamalekis 2000; Shennan 2006; Willcourt 1994).…”

Section: Resultsmentioning

confidence: 99%

“…No details of sample size. No usable data. Auner 1993 Different IV oxytocin dosing regimens, pulsatile versus continuous. oxytocin.…”

Section: Characteristics Of Included Studies [Ordered By Study Id]mentioning

confidence: 99%

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Intravenous oxytocin alone for cervical ripening and induction of labour

Alfirević

Kelly

Dowswell

2009

Cochrane Database of Systematic Reviews

158

129

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Background Oxytocin is the commonest induction agent used worldwide. It has been used alone, in combination with amniotomy or following cervical ripening with other pharmacological or non-pharmacological methods. Objectives To determine the effects of oxytocin alone for third trimester cervical ripening and induction of labour in comparison with other methods of induction of labour or placebo/no treatment. Search methods We searched the Cochrane Pregnancy and Childbirth Group’s Trials Register (January 2009) and bibliographies of relevant papers. Selection criteria Randomised and quasi-randomised trials comparing intravenous oxytocin with placebo or no treatment, or with prostaglandins (vaginal or intracervical) for third trimester cervical ripening or labour induction. Data collection and analysis Two review authors independently assessed eligibility and carried out data extraction. Main results Sixty-one trials (12,819 women) are included. When oxytocin inductions were compared with expectant management, fewer women failed to deliver vaginally within 24 hours (8.4% versus 53.8%, risk ratio (RR) 0.16, 95% confidence interval (CI) 0.10 to 0.25). There was a significant increase in the number of women requiring epidural analgesia (RR 1.10, 95% CI 1.04 to 1.17). Fewer women were dissatisfied with oxytocin induction in the one trial reporting this outcome (5.9% versus 13.7%, RR 0.43, 95% CI 0.33 to 0.56). Compared with vaginal prostaglandins, oxytocin increased unsuccessful vaginal delivery within 24 hours in the two trials reporting this outcome (70% versus 21%, RR 3.33, 95% CI 1.61 to 6.89). There was a small increase in epidurals when oxytocin alone was used (RR 1.09, 95% CI 1.01 to 1.17). Most of the studies included women with ruptured membranes, and there was some evidence that vaginal prostaglandin increased infection in mothers (chorioamnionitis RR 0.66, 95% CI 0.47 to 0.92) and babies (use of antibiotics RR 0.68, 95% CI 0.53 to 0.87). These data should be interpreted cautiously as infection was not pre-specified in the original review protocol. When oxytocin was compared with intracervical prostaglandins, there was an increase in unsuccessful vaginal delivery within 24 hours (50.4% versus 34.6%, RR 1.47, 95% CI 1.10 to 1.96) and an increase in caesarean sections (19.1% versus 13.7%, RR 1.37, 95% CI 1.08 to 1.74) in the oxytocin group. Authors’ conclusions Comparison of oxytocin with either intravaginal or intracervical PGE2 reveals that the prostaglandin agents probably increase the chances of achieving vaginal birth within 24 hours. Oxytocin induction may increase the rate of interventions in labour. A suggestion that for women with prelabour rupture of membranes induction with vaginal prostaglandin may increase risk of infection for mother and baby warrants further study.

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