Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

Villegas-Martínez, Manuel; Odland, Hans Henrik; Hammersbøen, Lars-Egil; Sletten, OJ; Stugaard, Marie; Witsø, Marit; Khan, Faraz; Wajdan, Ali; Elle, Ole Jakob; Remme, Espen W.

doi:10.1093/europace/euad013

Cited by 2 publications

(1 citation statement)

References 18 publications

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“…All these investigations have potential translational impact for further optimization of re-synchronization therapies. How the efficacy of such therapies can be evaluated best has also been studied in-depth, with the LV end-systolic volume, 12 the so-called heart-arterial coupling 13 and the pulse arrival time (the time the pulse waves need to travel from the LV to the lower limb 14 ) as potential markers of an acute response to cardiac re-synchronization therapy in experimental studies. These results require further clinical validation.…”

Section: Pacing and Ablationmentioning

confidence: 99%

25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies

Remme,

Heijman,

Gomez

et al. 2023

Europace

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In the last 25 years, EP Europace has published more than 300 basic and translational science articles covering different arrhythmia types (ranging from atrial fibrillation to ventricular tachyarrhythmias), different diseases predisposing to arrhythmia formation (such as genetic arrhythmia disorders and heart failure), and different interventional and pharmacological anti-arrhythmic treatment strategies (ranging from pacing and defibrillation to different ablation approaches and novel drug-therapies). These studies have been conducted in cellular models, small and large animal models, and in the last couple of years increasingly in silico using computational approaches. In sum, these articles have contributed substantially to our pathophysiological understanding of arrhythmia mechanisms and treatment options; many of which have made their way into clinical applications. This review discusses a representative selection of EP Europace manuscripts covering the topics of pacing and ablation, atrial fibrillation, heart failure and pro-arrhythmic ventricular remodelling, ion channel (dys)function and pharmacology, inherited arrhythmia syndromes, and arrhythmogenic cardiomyopathies, highlighting some of the advances of the past 25 years. Given the increasingly recognized complexity and multidisciplinary nature of arrhythmogenesis and continued technological developments, basic and translational electrophysiological research is key advancing the field. EP Europace aims to further increase its contribution to the discovery of arrhythmia mechanisms and the implementation of mechanism-based precision therapy approaches in arrhythmia management.

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Section: Pacing and Ablationmentioning

confidence: 99%

25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies

Remme,

Heijman,

Gomez

et al. 2023

Europace

View full text Add to dashboard Cite

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Concepts of Cardiac Dyssynchrony and Dynamic Approach

Catrina,

Batar,

Manitiu

et al. 2024

Diagnostics

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Cardiac conduction involves electrical activity from one myocyte to another, creating coordinated contractions in each. Disruptions in the conducting system, such as left bundle branch block (LBBB), can result in premature activation of specific regions of the heart, leading to heart failure and increased morbidity and mortality. Structural alterations in T-tubules and the sarcoplasmic reticulum can lead to dyssynchrony, a condition that can be treated by cardiac resynchronization therapy (CRT), which stands as a cornerstone in this pathology. The heterogeneity in patient responses underscored the necessity of improving the diagnostic approach. Vectocardiography, ultra-high-frequency ECG, 3D echocardiography, and electrocardiographic imaging seem to offer advanced precision in identifying optimal candidates for CRT in addition to the classic diagnostic methods. The advent of His bundle pacing and left bundle branch pacing further refined the approach in the treatment of dyssynchrony, offering more physiological pacing modalities that promise enhanced outcomes by maintaining or restoring the natural sequence of ventricular activation. HOT-CRT emerges as a pivotal innovation combining the benefits of CRT with the precision of His bundle or left bundle branch area pacing to optimize cardiac function in a subset of patients where traditional CRT might fall short.

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Pulse arrival time variation as a non-invasive marker of acute response to cardiac resynchronization therapy

Cited by 2 publications

References 18 publications

25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies

25 years of basic and translational science in EP Europace: novel insights into arrhythmia mechanisms and therapeutic strategies

Concepts of Cardiac Dyssynchrony and Dynamic Approach

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