“Pulse” methylprednisolone therapy in the treatment of severe glomerulonephritis

Effect of Glucocorticoid Therapy on Glucocorticoid Receptors in Children with Autoimmune Diseases

“…The therapy shows the same side effects as in adults with one major additional problem: it also inhibits linear growth. MP pulse therapy is a very effective treatment in autoimmune-mediated diseases (45)(46)(47)(48), with relatively mild and transient side effects in children (49) and is also believed not to interfere with linear growth (50,51). This therapy is especially important if rapid and strong control of disease activity is needed.…”

Myelitis: A Rare Presentation of Mumps

“…The advantage of an intravenous bolus of methylprednisolone over conventional corticosteroid therapy has been illustrated in acute renal transplant rejection, lupus nephritis and rapidly deteriorating glomerulonephritis [23,24]. Corticosteroids have many biologic effects, such as antiinflammatory, immunosuppressive, and also affect cell metabolism, phagocytosis, protein synthesis and membrane permeability [25].…”

Relapsing Nephrotic Syndrome

“…The mode of action of captopril in reducing proteinuria again appears to be by altering glomerular hemodynamics. <Pulse> méthylprednisolone given over 6-8 days was initially proposed for severe childhood proliferative glomerulonephritis [44] and has also been used extensively for diffuse proliferative lupus nephritis. The drug has been found to be effective in both steroiddependent and steroidresistant patients.…”