Pulse oximetry with clinical assessment to screen for congenital heart disease in neonates in China: a prospective study

Zhao, Qiyi; Ma, Xiaojing; Ge, Xiaoling; Liu, Fang; Yan, Weili; Wu, Lin; Ye, Ming; Liang, Xue‐cun; Zhang, Jing; Gao, Yan; Jia, Bing; Huang, Guoying

doi:10.1016/s0140-6736(14)60198-7

Cited by 184 publications

(195 citation statements)

References 20 publications

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“…7 Mathur et al in their study observed that the sensitivity of pulse oximetry to detect critical congenital heart disease and PPHN was 97.5% with negative predictive value of 99.5%. 8 They also concluded that the high negative predictive value is useful to reliably rule out critical congenital heart disease or PPHN among sick neonates, thus avoiding need for an urgent echocardiography.…”

Section: Discussionmentioning

confidence: 96%

Pulse oximetry as a simple diagnostic test for persistent pulmonary hypertension of newborn in limited resource settings

Anitha

Lakshmi

Darlington

2016

Int J Contemp Pediatr

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Section: Discussionmentioning

confidence: 96%

Pulse oximetry as a simple diagnostic test for persistent pulmonary hypertension of newborn in limited resource settings

Anitha

Lakshmi

Darlington

2016

Int J Contemp Pediatr

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“…deWahl Granelli [23] showed an increase in sensitivity of CCHD detection from 63% to 83% with specificity remaining at 98%. Similarly, Zhao et al showed increased sensitivity of CCHD detection from 77.4% to 93.2% with the addition of pulse oximetry screening to the newborn examination [24].…”

Section: Timing Of Pulse Oximetry Screening and Significance Of Falsementioning

confidence: 93%

“…The number of false positives for CCHD arising from the physical examination is significantly more than that from pulse oximetry screening [24]. One of the perceived impediments in introducing a pulse oximetry screening program is the need for rapid access to cardiology services to perform an echocardiogram in the event of a failed screening test.…”

Section: Response To a Positive Screenmentioning

confidence: 99%

Barriers to the Implementation of Newborn Pulse Oximetry Screening: A Different Perspective

Kluckow

2018

IJNS

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Pulse oximetry screening of the well newborn to assist in the diagnosis of critical congenital heart disease (CCHD) is increasingly being adopted. There are advantages to diagnosing CCHD prior to collapse, particularly if this occurs outside of the hospital setting. The current recommended approach links pulse oximetry screening with the assessment for CCHD. An alternative approach is to document the oxygen saturation as part of a routine set of vital signs in each newborn infant prior to discharge, delinking the measurement of oxygen saturation from assessment for CCHD. This approach, the way that many hospitals which contribute to the Australian New Zealand Neonatal Network (ANZNN) have introduced screening, has the potential benefits of decreasing parental anxiety and expectation, not requiring specific consent, changing the interpretation of false positives and therefore the timing of the test, and removing the pressure to perform an immediate echocardiogram if the test is positive. There are advantages of introducing a formal screening program, including the attainment of adequate funding and a universal approach, but the barriers noted above need to be dealt with and the process of acceptance by a national body as a screening test can take many years.

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“…10,11 While having high sensitivity for many of the target CCHDs, pulse oximetry, however, does not perform well for detection of aortic coarctation. In a clinical study performed in China 45 (Zhao et al), pulse oximetry was able to correctly detect three out of seven CoA cases to give a detection rate of 43%. Interestingly, in the same study, pulse oximetry with clinical assessment was able to detect 71% of the CoA cases, while, clinical assessment alone detected 57%.…”

Section: Two-dimensional Echocardiography Of Coarctation Of Aortamentioning

confidence: 99%

Automated detection of coarctation of aorta in neonates from two-dimensional echocardiograms

et al. 2017

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Abstract. Coarctation of aorta (CoA) is a critical congenital heart defect (CCHD) that requires accurate and immediate diagnosis and treatment. Current newborn screening methods to detect CoA lack both in sensitivity and specificity, and when suspected in a newborn, it must be confirmed using specialized imaging and expert diagnosis, both of which are usually unavailable at tertiary birthing centers. We explore the feasibility of applying machine learning methods to reliably determine the presence of this difficult-to-diagnose cardiac abnormality from ultrasound image data. We propose a framework that uses deep learning-based machine learning methods for fully automated detection of CoA from two-dimensional ultrasound clinical data acquired in the parasternal long axis view, the apical four chamber view, and the suprasternal notch view. On a validation set consisting of 26 CoA and 64 normal patients our algorithm achieved a total error rate of 12.9% (11.5% false-negative error and 13.6% false-positive error) when combining decisions of classifiers over three standard echocardiographic view planes. This compares favorably with published results that combine clinical assessments with pulse oximetry to detect CoA (71% sensitivity).

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Pulse oximetry with clinical assessment to screen for congenital heart disease in neonates in China: a prospective study

Cited by 184 publications

References 20 publications

Pulse oximetry as a simple diagnostic test for persistent pulmonary hypertension of newborn in limited resource settings

Pulse oximetry as a simple diagnostic test for persistent pulmonary hypertension of newborn in limited resource settings

Barriers to the Implementation of Newborn Pulse Oximetry Screening: A Different Perspective

Automated detection of coarctation of aorta in neonates from two-dimensional echocardiograms

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