Pulse Wave Amplitude Drops during Sleep are Reliable Surrogate Markers of Changes in Cortical Activity

Delessert, Alexandre; Espa, Fabrice; Rossetti, Andrea O.; Lavigne, Gilles; Tafti, Mehdi; Heinzer, Raphaël

doi:10.1093/sleep/33.12.1687

Cited by 48 publications

(39 citation statements)

References 40 publications

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“…A full PSG was not performed because it is more difficult and time-consuming than a PG; therefore, there was no information on sleep architecture, sleep time and quality, and EEG arousals. Consequently, the pulse-wave amplitude was used as a marker of an autonomic arousal [26]; this marker has shown its usefulness in assessing the efficacy of NIV during sleep in children and has also been used to assess the clinical consequences of persistent respiratory events during NIV in children [27]. It would have been interesting to determine the occurrence of hypercapnia after the different respiratory events; however, because of the time lag of the CO2 response, this was not feasible [23,28].…”

Section: Discussionmentioning

confidence: 99%

Polygraphic respiratory events during sleep in children treated with home continuous positive airway pressure: description and clinical consequences

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Polygraphic respiratory events during sleep in children treated with home continuous positive airway pressure: description and clinical consequences

et al. 2015

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“…[18], and the PLMS index (PLMSI) was calculated. As autonomic arousals were considered, the pulse-wave amplitude (PWA) drops (of at least 30% of baseline PWA) obtained from finger photoplethysmography, reflecting peripheral vasoconstriction [19,20]. The number and index per hour of sleep of autonomic arousals were calculated.…”

Section: Polysomnographymentioning

confidence: 99%

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

Haba‐Rubio

Frauscher

Marques‐Vidal

et al. 2017

Sleep

206

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Study Objectives: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography.Methods: Full polysomnographic data from 1,997 participants (age = 59 ± 11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD. Full polysomnography was performed at home. For participants screening positive for RBD, muscle activity during REM sleep was quantified to diagnose RBD.Results: Three hundred sixty-eight participants endorsed dream-enactment behavior on either of the two MUPS questions, and 21 fulfilled polysomnographic criteria for RBD, resulting in an estimated prevalence of 1.06% (95% CI = 0.61-1.50), with no difference between men and women. Compared with RBD− participants, RBD+ took more frequently antidepressants and antipsychotics (23.8% vs. 5.4%, p = .005; 14.3% vs. 1.5%, p = .004, respectively) and were more frequently smokers or exsmokers (85% vs. 56.6%, p = .011). On polysomnography, RBD+ had more stage N2 sleep (52 ± 11.5% vs. 46.3 ± 10.2%, p = .024) and less REM sleep (18 ± 6.4% vs. 21.9 ± 6.2%, p = .007), lower apnea-hypopnea index in REM sleep (3.8 ± 5.2 vs. 8.9 ± 13/hour, p = .035), and lower autonomic arousal index (31 ± 14.9 vs. 42.6 ± 19.5/hour, p = .002). Conclusions:In our middle-to-older age population-based sample, the prevalence of RBD was 1.06%, with no difference between men and women. RBD was associated with antidepressant and antipsychotic use and with minor differences in sleep structure.Key words: polysomnography; synucleinopathies; parasomnia; sleep; REM sleep without atonia Statement of SignificanceRapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia frequently associated or preceding neurodegenerative diseases such as synucleinopathies. Its occurrence in the general population is largely unknown. Analyzing data from 1,997 participants to the population-based HypnoLaus study who completed the Munich Parasomnia Screening questionnaire and had a complete polysomnography at home, we estimate the prevalence of RBD at 1.06%, with no significant difference between men and women. RBD was associated with antidepressant and antipsychotic use, and with minor differences in sleep structure. Knowing the prevalence and characteristics of RBD has important implications, as people with RBD can be ideal candidates for neuroprotective approaches, and can help us to better understand the progression of neurodegenerative disorders.

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“…Even though type 3 PMs cannot detect arousals because of the absence of EEG, indirect detection of arousals using surrogate signals have been elaborated. For instance, pulse-wave amplitude (PWA) drops have been shown to be a sensitive surrogate marker for EEG arousals 15. PWA drops is a non-invasive measure obtained from finger photoplethysmography provided by most pulse oximeters.…”

Section: Introductionmentioning

confidence: 99%

“…Even though this marker has not been validated in the general population, PWA drops sensitivity of 89.1% and 70.9% for EEG arousals were reported in patients with non-invasive ventilation and in patients with OSA respectively 15 16. Moreover the magnitude of PWA drops is associated with the EEG arousal intensity and the use of PWA drops as surrogate for EEG arousal was shown to improve inter-scorer reliability for PSG 17 18…”

Section: Introductionmentioning

confidence: 99%

Scoring criteria for portable monitor recordings: a comparison of four hypopnoea definitions in a population-based cohort

Vat

Haba‐Rubio²,

Tafti

et al. 2015

Thorax

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Pulse Wave Amplitude Drops during Sleep are Reliable Surrogate Markers of Changes in Cortical Activity

Cited by 48 publications

References 40 publications

Polygraphic respiratory events during sleep in children treated with home continuous positive airway pressure: description and clinical consequences

Polygraphic respiratory events during sleep in children treated with home continuous positive airway pressure: description and clinical consequences

Prevalence and determinants of rapid eye movement sleep behavior disorder in the general population

Scoring criteria for portable monitor recordings: a comparison of four hypopnoea definitions in a population-based cohort

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