Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito, Michiyuki; Saito, Wataru; Hirooka, Kiriko; Hashimoto, Yuki; Mori, Shiro; Noda, Kousuke; Ishida, Susumu

doi:10.1167/iovs.15-17246

Cited by 56 publications

(54 citation statements)

References 33 publications

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“…Low-flow signal areas seen in the type 1 pattern of CSC might indicate the accumulation of serous contents in the choroid due to increased hydrostatic pressure, the thinned choriocapillaris being pushed upward by ‘pachyvessels' [19], or low blood flow attributable to an imbalance in the distribution of choroidal blood flow [20] at the choriocapillaris level. In the type 1 CSC pattern, there was an overlay of flow signals on the OCT B-scans obtained at the subfoveal choriocapillaris level.…”

Section: Discussionmentioning

confidence: 99%

Findings of Optical Coherence Tomographic Angiography at the Choriocapillaris Level in Central Serous Chorioretinopathy

et al. 2016

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Purpose: To reveal vascular signals at the choriocapillaris level in central serous chorioretinopathy (CSC) using optical coherence tomographic angiography (OCTA). Procedures: We analyzed vascular signals at the choriocapillaris level in 58 CSC and 51 contralateral eyes by OCTA (RTVue XR Avanti with AngioVue; Optovue Inc., Fremont, Calif., USA). Data analysis included age, best corrected visual acuity (BCVA), disease duration and serous retinal detachment (SRD) height. Results: Morphologically, abnormal signals at the choriocapillaris level were detected in all CSC eyes (100%), and then classified into three patterns. Age, BCVA, disease duration and SRD height showed no significant correlation with signal patterns. Thirty-one contralateral eyes (61%) showed abnormal signals at the choriocapillaris level on OCTA, while 20 (39%) had a normal pattern. Conclusions: OCTA revealed three types of abnormal signals not only in CSC eyes but also in fellow eyes without SRD. OCTA may provide information for elucidating the underlying pathogenesis of CSC.

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Section: Discussionmentioning

confidence: 99%

Findings of Optical Coherence Tomographic Angiography at the Choriocapillaris Level in Central Serous Chorioretinopathy

et al. 2016

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“…[22] As a further example, LSFG has helped corroborate the hypothesis that choroidal hyperperfusion may be involved in the development of central serous chorioretinopathy. [19,21]…”

Section: Introductionmentioning

confidence: 99%

Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy

et al. 2016

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PurposeTo assess the feasibility and reliability of Laser Speckle Flowgraphy (LSFG) to measure ocular perfusion in a sample of healthy white subjects and to elucidate the age-dependence of the parameters obtained.MethodsThis cross-sectional study included 80 eyes of 80 healthy, non-smoking white subjects of Western European descent between 19 and 79 years of age. A commercial LSFG instrument was applied to measure ocular blood flow at the optic nerve head (ONH) three successive times before and after pharmacological pupil dilation. The mean blur rate (MBR), a measure of relative blood flow velocity, was obtained for different regions of the ONH. Eight parameters of ocular perfusion derived from the pulse-waveform analysis of MBR including blowout time (BOT) and falling rate (FR) were also recorded.ResultsArtifact-free LSFG images meeting the quality criteria for automated image analysis were obtainable in 93.8% without pupil dilation and in 98.8% with pharmacological pupil dilation. Measurements of MBR showed excellent repeatability with intraclass correlation coefficients ≥ 0.937 and were barely affected by pupil dilation. The majority of pulse-waveform derived variables exhibited equally high repeatability. MBR-related blood flow indices exhibited significant age dependence (p<0.001). FR (r = 0.747, p<0.001) and BOT (r = -0.714, p<0.001) most strongly correlated with age.ConclusionsLSFG represents a reliable method for the quantitative assessment of ocular blood flow in white subjects. Our data affirms that the LSFG-derived variables FR and BOT may be useful biomarkers for age-related changes in ocular perfusion.

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“…LSFG has already been used to evaluate ocular hemodynamics in a number of clinical and experimental studies, and has proven particularly useful in studies of glaucoma Aizawa et al, 2011;Cull, Burgoyne, Fortune, & Wang, 2013;Fan, Wang, Tang, & Liu, 2015;Kobayashi et al, 2014;Shiga et al, 2013;Sugiyama et al, 2010;Tsuda et al, 2013;Wang, Cull, Piper, Burgoyne, & Fortune, 2012). MBR can also serve as a useful biomarker of positive postoperative visual outcomes in eyes with retinal diseases Kunikata and Nakazawa, 2016;Nitta et al, 2014;Saito et al, 2015). Recently, it was reported that peripheral hemodynamics were negatively correlated with oxidative stress in healthy subjects, as well as in those with chronic heart failure (Inoue et al, 2012;Nozawa, Ishizaki, Kuroda, & Noguchi, 2008).…”

Section: Introductionmentioning

confidence: 99%

The relationship between advanced glycation end products and ocular circulation in type 2 diabetes

Hashimoto

Kunikata

Yasuda

et al. 2016

Journal of Diabetes and its Complications

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Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Cited by 56 publications

References 33 publications

Findings of Optical Coherence Tomographic Angiography at the Choriocapillaris Level in Central Serous Chorioretinopathy

Findings of Optical Coherence Tomographic Angiography at the Choriocapillaris Level in Central Serous Chorioretinopathy

Ocular Blood Flow Measurements in Healthy White Subjects Using Laser Speckle Flowgraphy

The relationship between advanced glycation end products and ocular circulation in type 2 diabetes

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