Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury

Peng, Shuping; Li, Yining; Liu, Jun; Wang, Zhiyuan; Zhang, Zishu; Zhou, Shiwei; Tao, Fangxu; Zhang, Zhixue

doi:10.4103/1673-5374.177733

Cited by 18 publications

(2 citation statements)

References 18 publications

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“…46 Similar findings have been described in the acute phase with regional blood flow reductions correlating with post-concussive symptoms in studies with arterial spin label MR imaging. 47,48 Abnormal regional cerebral blood flow has also been demonstrated in chronic pediatric mild traumatic brain injury 49 and in adults 2 years following concussion. 50 Further studies are, however, needed to determine whether or not non-contrast enhanced regional blood flow imaging may inform prognosis following concussion in youth athletes.…”

Section: Imaging Findings/pathologymentioning

confidence: 99%

Imaging of Concussion in Young Athletes

Guenette

Shenton

Koerte

2018

Neuroimaging Clinics of North America

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Conventional neuroimaging examinations are typically normal in concussed young athletes. A current focus of research is the characterization of subtle abnormalities after concussion using advanced neuroimaging techniques. These techniques have the potential to identify biomarkers of concussion. In the future, such biomarkers will likely provide important clinical information regarding the appropriate time interval before return to play, as well as the risk for prolonged postconcussive symptoms and long-term cognitive impairment. This article discusses results from advanced imaging techniques and emphasizes imaging modalities that will likely become available in the near future for the clinical evaluation of concussed young athletes.

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Section: Imaging Findings/pathologymentioning

confidence: 99%

Imaging of Concussion in Young Athletes

Guenette

Shenton

Koerte

2018

Neuroimaging Clinics of North America

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“…Although neuroimaging of CBF ( 11 , 12 ) is used to assess brain injury and recovery in neurointensive care, the role of CBF monitoring is limited as it is usually not continuous and acquired by expensive MRI ( 13 ) and computed tomography scanners ( 14 ). Transcranial Doppler ultrasound ( 15 ) is quasi-continuous but measures macrovessel velocity, not microvascular flow, and can be position-dependent and challenging in many subjects, even with a skilled operator.…”

Section: Introductionmentioning

confidence: 99%

Functional interferometric diffusing wave spectroscopy of the human brain

et al. 2021

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Cerebral blood flow (CBF) is essential for brain function, and CBF-related signals can inform us about brain activity. Yet currently, high-end medical instrumentation is needed to perform a CBF measurement in adult humans. Here, we describe functional interferometric diffusing wave spectroscopy (fiDWS), which introduces and collects near-infrared light via the scalp, using inexpensive detector arrays to rapidly monitor coherent light fluctuations that encode brain blood flow index (BFI), a surrogate for CBF. Compared to other functional optical approaches, fiDWS measures BFI faster and deeper while also providing continuous wave absorption signals. Achieving clear pulsatile BFI waveforms at source-collector separations of 3.5 cm, we confirm that optical BFI, not absorption, shows a graded hypercapnic response consistent with human cerebrovascular physiology, and that BFI has a better contrast-to-noise ratio than absorption during brain activation. By providing high-throughput measurements of optical BFI at low cost, fiDWS will expand access to CBF.

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Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

Lunkova

Guberman

Ptito

et al. 2021

Human Brain Mapping

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Mild traumatic brain injury (mTBI), frequently referred to as concussion, is one of the most common neurological disorders. The underlying neural mechanisms of functional disturbances in the brains of concussed individuals remain elusive. Novel forms of brain imaging have been developed to assess patients postconcussion, including functional magnetic resonance imaging (fMRI), susceptibility‐weighted imaging (SWI), diffusion MRI (dMRI), and perfusion MRI [arterial spin labeling (ASL)], but results have been mixed with a more common utilization in the research environment and a slower integration into the clinical setting. In this review, the benefits and drawbacks of the methods are described: fMRI is an effective method in the diagnosis of concussion but it is expensive and time‐consuming making it difficult for regular use in everyday practice; SWI allows detection of microhemorrhages in acute and chronic phases of concussion; dMRI is primarily used for the detection of white matter abnormalities, especially axonal injury, specific for mTBI; and ASL is an alternative to the BOLD method with its ability to track cerebral blood flow alterations. Thus, the absence of a universal diagnostic neuroimaging method suggests a need for the adoption of a multimodal approach to the neuroimaging of mTBI. Taken together, these methods, with their underlying functional and structural features, can contribute from different angles to a deeper understanding of mTBI mechanisms such that a comprehensive diagnosis of mTBI becomes feasible for the clinician.

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Pulsed arterial spin labeling effectively and dynamically observes changes in cerebral blood flow after mild traumatic brain injury

Cited by 18 publications

References 18 publications

Imaging of Concussion in Young Athletes

Imaging of Concussion in Young Athletes

Functional interferometric diffusing wave spectroscopy of the human brain

Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis

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