Pulsed cold plasma-induced blood coagulation and its pilot application in stanching bleeding during rat hepatectomy

Yan, Keping; Jin, Qikang; Zheng, Chao; Deng, Guanlei; Yin, Shengyong; Liu, Zhen

doi:10.1088/2058-6272/aa9b79

Cited by 14 publications

(7 citation statements)

References 20 publications

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“…In the laboratory, we also usually get plasma in the form of gas discharge. Typical electrical discharges that produce cold plasma at atmospheric pressure include corona, dielectric barrier discharge (DBD) and atmospheric-pressure plasma jet (APPJ) [1], and some other plasma sources (Fig. 2).…”

Section: What Is Plasma?mentioning

confidence: 99%

Plasma medicine for neuroscience—an introduction

et al. 2019

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Plasma is an ionized gas. It is typically formed at high temperature. As a result of both the development of lowtemperature plasma sources and a better understanding of complex plasma phenomena over the last decade, "plasma medicine" has become a booming interdisciplinary research topic of growing importance that explores enormous opportunities at the interface of chemistry, plasma physics, and biomedical sciences with engineering. This review presents the latest development in plasma medicine in the area of the central nervous system and aims to introduce cutting-edge plasma medicine to clinical and translational medical researchers and practitioners.

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Section: What Is Plasma?mentioning

confidence: 99%

Plasma medicine for neuroscience—an introduction

et al. 2019

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“…Using the properties of physical plasma, medical gas plasma technology has been successfully investigated for the treatment of several types of diseases. Known and upcoming applications include decontamination, wound healing, blood coagulation, surface modifications, dentistry, and the treatment of various medical conditions, including cancer [1][2][3][4][5]. The latter is among the most investigated in the past few years because cancer mortality is still not significantly declining, current treatment schemes often come with severe side effects, and therapy resistance is an urgent issue, even with new treatment modalities.…”

Section: Introductionmentioning

confidence: 99%

Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities

et al. 2020

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Despite progress in oncotherapy, cancer is still among the deadliest diseases in the Western world, emphasizing the demand for novel treatment avenues. Cold physical plasma has shown antitumor activity in experimental models of, e.g., glioblastoma, colorectal cancer, breast carcinoma, osteosarcoma, bladder cancer, and melanoma in vitro and in vivo. In addition, clinical case reports have demonstrated that physical plasma reduces the microbial contamination of severely infected tumor wounds and ulcerations, as is often seen with head and neck cancer patients. These antimicrobial and antitumor killing properties make physical plasma a promising tool for the treatment of head and neck cancer. Moreover, this type of cancer is easily accessible from the outside, facilitating the possibility of several rounds of topical gas plasma treatment of the same patient. Gas plasma treatment of head and neck cancer induces diverse effects via the deposition of a plethora of reactive oxygen and nitrogen species that mediate redox-biochemical processes, and ultimately, selective cancer cell death. The main advantage of medical gas plasma treatment in oncology is the lack of adverse events and significant side effects compared to other treatment modalities, such as surgical approaches, chemotherapeutics, and radiotherapy, making plasma treatment an attractive strategy for the adjuvant and palliative treatment of head and neck cancer. This review outlines the state of the art and progress in investigating physical plasma as a novel treatment modality in the therapy of head and neck squamous cell carcinoma.

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“…It is well-known that medical plasma can effectively inactivate various bacteria, viruses, and other pathogenic microorganisms [5][6][7][8][9][10][11], and efficiently avoid the disadvantages of chemical residues of traditional chemical methods. Various plasma sources have been developed, optimized for a wide range of medical applications, including sterilization and disinfection [12][13][14], cancer cell treatment [15][16][17], wound healing [18][19][20], and skin cleaning [21][22][23]. Currently, the main plasma sources used for low-temperature plasmas are dielectric barrier discharge, spark discharge, and jet discharge.…”

Section: Introductionmentioning

confidence: 99%

Design and characteristics investigation of a miniature low-temperature plasma spark discharge device

Zhou

Zhang

et al. 2019

Plasma Sci. Technol.

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Atmospheric pressure low-temperature plasma is a promising tool in biomedicine applications including blood coagulation, bacterial inactivation, sterilization, and cancer treatment, due to its high chemical activity and limited thermal damage. It is of great importance to develop portable plasma sources that are safe to human touch and suitable for outdoor and household operation. In this work, a portable and rechargeable low-temperature plasma spark discharge device (130 mm×80 mm× 35 mm, 300 g) was designed. The discharge frequency and plume length were optimized by the selection of resistance, capacitance, electrode gap, and ground electrode aperture. Results show that the spark plasma plume is generated with a length of 12 mm and a frequency of 10 Hz at a capacitance of 0.33 μF, resistance of 1 MΩ, electrode gap of 2 mm, and ground electrode aperture of 1.5 mm. Biological tests indicate that the plasma produced by this device contains abundant reactive species, which can be applied in plasma biomedicine, including daily sterilization and wound healing.

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Pulsed cold plasma-induced blood coagulation and its pilot application in stanching bleeding during rat hepatectomy

Cited by 14 publications

References 20 publications

Plasma medicine for neuroscience—an introduction

Plasma medicine for neuroscience—an introduction

Medical Gas Plasma Treatment in Head and Neck Cancer—Challenges and Opportunities

Design and characteristics investigation of a miniature low-temperature plasma spark discharge device

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