Pulsed‐dye laser treatment for recalcitrant viral warts: a retrospective case series of 227 patients

Abstract

4 Sandroni P, Martin DP, Bruce BK et al. Congenital idiopathic inability to perceive pain: a new syndrome of insensitivity to pain and itch with preserved small fibers. Pain 2006; 122:210-15. 5 Weiss J, Pyrski M, Jacobi E et al. Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. Nature 2011; 472:186-90. 6 Rush AM, Dib-Hajj SD, Liu S et al. A single sodium channel mutation produces hyper-or hypoexcitability in different types of neurons. Proc Natl Acad Sci USA 2006; 103:8245-50. 7 Han C, Hoeijmakers JG, Liu S et al. Functional profiles of SCN9A variants in dorsal root ganglion neurons and superior cervical ganglion neurons correlate with autonomic symptoms in small fibre neuropathy. Brain 2012; 135(Pt 9):2613-28. 8 Yuan J, Matsuura E, Higuchi Y et al. Hereditary sensory and autonomic neuropathy type IID caused by an SCN9A mutation. Neurology 2013; 80:1641-9. 9 Kim MK, Yuk JW, Kim HS et al. Autonomic dysfunction in SCN9A-associated primary erythromelalgia. Clin Auton Res 2013; 23:105-7. 10 Dib-Hajj SD, Estacion M, Jarecki BW et al. Paroxysmal extreme pain disorder M1627K mutation in human Nav1.7 renders DRG neurons hyperexcitable. Mol Pain 2008; 4:37.Funding sources: no external funding.Conflicts of interest: none declared.

Long pulse Alexandrite laser for recalcitrant viral warts on the hands

“…Interestingly, a large retrospective study showed a high percentage of clearance of warts using high fluencies (12.5-15 J/cm²) with PDL. 5 Along with our present results, it might be hypothesiszed that the use of high fluencies could induce necrosis and is needed for optimal clearance of the warts. …”

“…3 These data infer that the quality/quantity of AT1R gene expression is correlated with psoriasis and its complications such as hypertension, heart disease and oxidative stress. [4][5][6] To confirm this notion, we studied the clinical significance of the AT1RA 1166 C receptor polymorphism and its relationship with serum concentration of lipids, oxidant/antioxidant systems and vascular adhesion protein-1(VAP-1) in 100 psoriatic patients and 100 gender-and age-matched unrelated healthy controls from west population of Iran. After informed consent, genomic DNA was extracted from the individual's peripheral blood leucocytes and AT1RA 1166 C polymorphism was detected by PCR-RFLP as previously described (Fig.…”

“…1). 5 Serum arylesterase (ARE) 6 and catalase activities were detected by spectrophotometry, superoxide dismutase (SOD) activity and VAP-1 were measured by ELISA and malondialdehyde (MDA) level was detected by HPLC. 6-8 The genotypes and allele frequencies of AT1R 1166 C/A in psoriasis patients were compared to control group using chi-squared test in four different models: codominant (A/C or C/C vs. A/A), dominant (A/C+ C/C…”

Therapeutic management of cutaneous and genital warts

“…A study of 227 patients, the largest number of patients with recalcitrant warts treated to date, was recently published by Sparreboom et al. . The clearance rate, including the one‐year follow‐up period, ultimately came to a total of 86 %.…”

Therapeutisches Management kutaner und genitaler Warzen

“…Die bislang größte behandelte Patientenzahl mit therapieresistenten Verrucae von insgesamt 227 Patienten wurde kürzlich von Sparreboom et al. beschrieben . Am Ende zeigte sich eine Abheilung, auch im Nachbeobachtungszeitraum von einem Jahr, von insgesamt 86 %.…”