Pulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: Effects on T‐cell infiltration, epidermal proliferation and keratinization

Bovenschen, Jorn H.; Erceg, A.; Vlijmen-Willems, Ivonne van; Kerkhof, P.C.M. van de; Seyger, M.M.B.

doi:10.1080/09546630601028760

Cited by 18 publications

(8 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Besides destruction of blood vessels, PDL can reduce the number of helper T cells in the dermis and cytotoxic T cells in the epidermis, and normalize epidermal proliferation, which improves the clinical signs of psoriasis vulgaris. 30,31 The pulse durations in these studies were between 0.35 and 1.5 milliseconds. [23][24][25][26][27] To date, few studies have demonstrated the efficacy of PDL on nail psoriasis.…”

Section: Discussionmentioning

confidence: 99%

The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: A randomized, double-blind, intrapatient left-to-right study

Treewittayapoom

Singvahanont

Chanprapaph

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: A randomized, double-blind, intrapatient left-to-right study

Treewittayapoom

Singvahanont

Chanprapaph

et al. 2012

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

“…This could be because of the poor penetration of UVB in the human nail plate [ 22 ]. PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed [ 23 , 24 ]. PDL treatment decreases the number of dermal papillary microvessels, which are important pathogenetic targets of psoriasis; PDL therapy, as it selectively targets superficial vessels, is therefore a valid therapeutic approach [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Single Blinded Left-to-Right Comparison Study of Excimer Laser Versus Pulsed Dye Laser for the Treatment of Nail Psoriasis

Al-Mutairi

Noor

Al-Haddad

2014

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

IntroductionNail psoriasis is relatively difficult to treat. Excimer laser has been approved for the treatment of psoriasis since 2000. Pulsed dye laser (PDL) in psoriasis therapy has shown good response rates, with extended remissions. This is the first study assessing both the excimer and PDL lasers in nail psoriasis.MethodsIn a comparison study, excimer laser versus PDL for the treatment of nail psoriasis was evaluated in 42 patients. The right hand nails were treated with excimer laser twice weekly and the left hand nails were treated with PDL once every 4 weeks, for total 12 weeks. The patients were then followed up after a further 12 weeks. Nail Psoriasis Severity Index (NAPSI) scores were recorded at baseline, weeks 4, 8, and 12, and then at week 24. Patients were also asked to grade the clinical response to each treatment.ResultsA total of 304 nail changes, 148 with excimer laser and 156 with PDL, were treated. The mean NAPSI score in nails treated with excimer laser was 29.8 at baseline, reduced to 16.3 at week 24. In PDL-treated nails, the NAPSI scores dropped from 29.5 at baseline to 3.2 at week 24. NAPSI improvement was significantly greater in PDL than excimer (P = 0.001; Wilcoxon signed-rank test). Thirty-four (81%) hands achieved NAPSI-50, and 23 (55%) achieved NAPSI-75 at week 12, while complete nail recovery was shown in 6 (14%) hands treated with PDL. Regarding the hands treated with excimer laser, only 16 (38%) hands achieved NAPSI-50, while no hands achieved NAPSI-75 at week 12. In general, subungual hyperkeratosis and onycholysis improved significantly, while nail pitting was least responsive. Oil drops and splinter hemorrhages showed moderate response.ConclusionsWhen compared to excimer laser, PDL demonstrated a good response for treating nail psoriasis, with minimal side effects.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-014-0057-y) contains supplementary material, which is available to authorized users.

show abstract

“…PDL-induced selective photothermolysis of hemoglobin in vessels was one of the mechanisms of the clearance of psoriatic lesions. Apart from photothermolysis, PDL also reduced activated and memory effector Th cells in the dermis and cytotoxic T cells in the epidermis in plaque psoriasis [ 35 ], concurrent with induction of cytokine expression and collagen formation [ 36 ]. Studies about PDL treatment of hypertrophic scar have shown that PDL is strongly absorbed by hemoglobin, leading to coagulation necrosis in vessels, hypoperfusion, and local hypoxia [ 37 ].…”

Section: Pulsed Dye Laser Treatment and Its Mechanismmentioning

confidence: 99%

A clinical review of phototherapy for psoriasis

2017

View full text Add to dashboard Cite

Psoriasis is an autoimmune inflammatory skin disease. In the past several decades, phototherapy has been widely used to treat stable psoriatic lesions, including trunk, scalp, arms and legs, and partial nail psoriasis. A variety of light/lasers with different mechanisms of action have been developed for psoriasis including ultraviolet B (UVB), psoralen ultraviolet A (PUVA), pulsed dye laser (PDL), photodynamic therapy (PDT), intense pulsed light (IPL), light-emitting diodes (LED), and so on. Because light/laser each has specific therapeutic and adverse effects, it is important to adequately choose the sources and parameters in management of psoriasis with different pathogenic sites, severities, and duration of the disorder. This review aims at providing most updated clinic information to physicians about how to select light/laser sources and individual therapeutic regimens. To date, UV light is primarily for stable plaque psoriasis and PDL for topical psoriatic lesions with small area, both of which are safe and effective. On the other hand, PUVA has better curative effects than UVB for managing refractory psoriasis plaques, if its side effects can be better controlled. PDL provides optimal outcomes on nail psoriasis compared with other lasers. Although the trails of low-level light/laser therapy (LLLT) are still small, the near infrared (NIR) and visible red light with low energy show promise for treating psoriasis due to its strong penetration and encouraging photobiomodulation. IPL is rarely reported for psoriasis treatment, but PDT-IPL has been found to offer a moderate effect on nail psoriasis. In brief, various phototherapies have been used either in different combinations or as monotherapy. The modality has become a mainstay in the treatment of mild-to-moderate psoriasis without systemic adverse events in today’s clinical practice.

show abstract

Pulsed dye laser versus treatment with calcipotriol/betamethasone dipropionate for localized refractory plaque psoriasis: Effects on T‐cell infiltration, epidermal proliferation and keratinization

Cited by 18 publications

References 26 publications

The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: A randomized, double-blind, intrapatient left-to-right study

The effect of different pulse durations in the treatment of nail psoriasis with 595-nm pulsed dye laser: A randomized, double-blind, intrapatient left-to-right study

Single Blinded Left-to-Right Comparison Study of Excimer Laser Versus Pulsed Dye Laser for the Treatment of Nail Psoriasis

A clinical review of phototherapy for psoriasis

Contact Info

Product

Resources

About