Pulsed Electromagnetic Field Protects Against Brain Injury After Intracerebral Hemorrhage: Involvement of Anti-Inflammatory Processes and Hematoma Clearance via CD36

Yang, Yuefan; Wang, Pan; Liu, Anlai; Wu, Xiuquan; Yan, Zedong; Dai, Shuhui; Wei, Jialiang; Zhang, Zhuoyuan; Li, Xin; Luo, Peng; Luo, Erping

doi:10.1007/s12031-022-02063-1

Cited by 5 publications

(4 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…EMFs have been found to be generated through electrochemical signaling at the neuronal level. These EMFs have been evaluated in a variety of different conditions [ 1 , 2 , 12 , 13 , 22 ]. Furthermore, TMS has been investigated in early-phase research as a treatment for brain injury, resulting in some early success in preclinical models with the reversal of histological injury and improvement in physiologic functioning [ 11 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, brain neuronal circuit stimulation technologies have not yet been investigated using targeted EMF measurements developed from pre-CCI to post-CCI changes to attempt to directly stimulate abnormal pathways and modulate the abnormal EMF signal. It is thought that modulating the abnormal EMF signal may reduce deleterious effects from inflammatory cytokines, abnormal signaling, and cortical depressions and may produce regenerative effects on neurons to allow for the recovery of these injured cells and circuits [ 2 , 13 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Swine Model of Traumatic Brain Injury: Effects of Neuronally Generated Electromagnetic Fields and Electromagnetic Field Stimulation on Traumatic Brain Injury-Related Changes

Brazdzionis¹,

Radwan²,

Thankam³

et al. 2023

Cureus

View full text Add to dashboard Cite

Background and objective Traumatic brain injury (TBI) has been associated with aberrations in neural circuitry attributable to the pathology resulting in electromagnetic field (EMF) changes. These changes have been evaluated in a variety of settings including through novel induction sensors with an ultra-portable shielded helmet and EMF channels with differences identified by comparing pre-injury and post-injury states. Modulation of the EMF has undergone cursory evaluation in neurologic conditions but has not yet been fully evaluated for clinical effects in treatment. Target EMF stimulation using EMF-related changes preoperatively to postoperatively has not yet been attempted and has not been completed using induction sensor technology. Our objectives in this study were twofold: we wanted to test the hypothesis that targeted stimulation using an EMF signal generator and stimulator to abnormal thresholds identified by real-time measurement of EMFs may enable early resolution of EMF changes and treatment of the TBI as modeled through controlled cortical impact (CCI); we also aimed to assess the feasibility of attempting this using real-time measurements with an EMF shielded helmet with EMF channels and non-contact, non-invasive induction sensors with attached EMF transmitters in real-time. Methods A singular Yucatan miniswine was obtained and baseline EMF recordings were obtained. A CCI of TBI and postoperative assessment of cortical EMF in a non-invasive, non-contact fashion were completed. Alterations in EMF were evaluated and EMF stimulation using those abnormal frequencies was completed using multiple treatments involving three minutes of EMF stimulation at abnormal frequencies. Stimulation thresholds of 2.5 Hz, 3.5 Hz, and 5.5 Hz with 1 V signal intensity were evaluated using sinusoidal waves. Additionally, stimulation thresholds using differing offsets to the sine wave at -500 mV, 0 mV, and 500 mv were assessed. Daily EMF and post-stimulation EMF measurements were recorded. EMF patterns were then assessed using an artificial intelligence (AI) model. Results AI modeling appropriately identified differences in EMF signal in pre-injury, post-injury, and post-stimulation states. EMF stimulation using a positive offset of 500 mV appeared to have maximal beneficial effects in return to baseline. Similarly targeted stimulation using thresholds of 2.5 Hz and 5.5 Hz with a positive 500 mV offset at 1 V allowed for recovery of EMF patterns post-injury towards patterns seen in baseline EMF measurements on stimulation day seven (postoperative day 17). Conclusion Stimulation of neural circuits with targeted EMF in a sinusoidal pattern with targeted thresholds after measurement with induction sensors with shielding isolated to a Mu-metal and copper mesh helmet and EMF channels is efficacious in promoting neuronal circuit recovery to preoperative baselines in the TBI miniswine model. Similarly, our findings confirm the appropriateness of thi...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Swine Model of Traumatic Brain Injury: Effects of Neuronally Generated Electromagnetic Fields and Electromagnetic Field Stimulation on Traumatic Brain Injury-Related Changes

Brazdzionis¹,

Radwan²,

Thankam³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…In this context, rTMS is a leading candidate modality and many animal models support the use of rTMS for TBI. Yang et al (2012) reported that 15 Hz electromagnetic fields were neuroprotective in rats with TBI [ 54 ]. In contrast, Yoon et al (2015 did not find evidence of motor recovery from rTMS in a rat model of TBI [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Preliminary Observations of Personalized Repetitive Magnetic Stimulation (PrTMS) Guided by EEG Spectra for Concussion

Makale,

Nybo,

Keifer

et al. 2023

Brain Sciences

View full text Add to dashboard Cite

There are no FDA-approved treatments for the chronic sequelae of concussion. Repetitive magnetic transcranial stimulation (rTMS) has been explored as a therapy but outcomes have been inconsistent. To address this we developed a personalized rTMS (PrTMS) protocol involving continual rTMS stimulus frequency adjustment and progressive activation of multiple cortical sites, guided by spectral electroencephalogram (EEG)-based analyses and psychological questionnaires. We acquired pilot clinical data for 185 symptomatic brain concussion patients who underwent the PrTMS protocol over an approximate 6 week period. The PrTMS protocol used a proprietary EEG spectral frequency algorithm to define an initial stimulation frequency based on an anteriorly graded projection of the measured occipital alpha center peak, which was then used to interpolate and adjust regional stimulation frequency according to weekly EEG spectral acquisitions. PrTMS improved concussion indices and normalized the cortical alpha band center frequency and peak EEG amplitude. This potentially reflected changed neurotransmitter, cognitive, and perceptual status. PrTMS may be a promising treatment choice for patients with persistent concussion symptoms. This clinical observational study was limited in that there was no control group and a number of variables were not recorded, such as time since injury and levels of depression. While the present observations are indeed preliminary and cursory, they may suggest further prospective research on PrTMS in concussion, and exploration of the spectral EEG as a concussion biomarker, with the ultimate goals of confirmation and determining optimal PrTMS treatment parameters.

show abstract

“…Despite specifying some of their stimulation parameters, the homogeneity of the magnetic field and the induced electric field in the biological samples' area was not assessed, in this study. Yang et al [46] applied PEMF to BV2 cells, a type of microglial cell, to assess possible anti-inflammatory protective effects against brain injury. Although the electromagnetic field output was measured through a Gaussmeter, its homogeneity in the entire center area of the Helmholtz coils, where the bottom of the cell culture plates was positioned, was not verified.…”

Section: Discussionmentioning

confidence: 99%

Pulsed Electromagnetic Field Stimulation Enhances Neurite Outgrowth in Neural Cells and Modulates Inflammation in Macrophages

Fontana¹,

Cafarelli²,

Iacoponi³

et al. 2023

Preprint

View full text Add to dashboard Cite

Pulsed Electromagnetic Field Protects Against Brain Injury After Intracerebral Hemorrhage: Involvement of Anti-Inflammatory Processes and Hematoma Clearance via CD36

Cited by 5 publications

References 37 publications

A Swine Model of Traumatic Brain Injury: Effects of Neuronally Generated Electromagnetic Fields and Electromagnetic Field Stimulation on Traumatic Brain Injury-Related Changes

A Swine Model of Traumatic Brain Injury: Effects of Neuronally Generated Electromagnetic Fields and Electromagnetic Field Stimulation on Traumatic Brain Injury-Related Changes

Preliminary Observations of Personalized Repetitive Magnetic Stimulation (PrTMS) Guided by EEG Spectra for Concussion

Pulsed Electromagnetic Field Stimulation Enhances Neurite Outgrowth in Neural Cells and Modulates Inflammation in Macrophages

Contact Info

Product

Resources

About