Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat

Márquez‐Gamiño, Sergio; Sotelo, F; Sosa, M.; Caudillo, Cipriana; Holguín, G.; Ramos, Ma. Eugenia Sánchez; Francisco, Mesa; Bernal, José Joaquín Pinto; Córdova, T.

doi:10.1002/bem.20396

Cited by 17 publications

(7 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, the analysis in the case of axial loads has not been previously reported on this kind of bones, as well as the loading calibration based on carrier fringes over the background and on the bone. Further studies are under way by the authors to use this technique to detect changes in the structural integrity of small bones due to pathological conditions or external agents like pulsed electromagnetic fields [11]. …”

Section: Discussionmentioning

confidence: 99%

Axial loading verification method for small bones using carrier fringes in speckle pattern interferometry

Dávila

Marquez

Landgrave

et al. 2015

Journal of Modern Optics

Self Cite

View full text Add to dashboard Cite

A computerized system for real-time displacement visualization using carrier fringes in an electronic speckle in-plane sensitive interferometer allows force calibration for micro-displacement analysis of rat bones and verification of axial loading conditions. Once the force has been calibrated and the load is applied along the bone axis, the difference-ofphase method is used to obtain the phase map, which after phase unwrapping, allows the evaluation of the displacements produced by the bone deformation. The proposed method avoids common loading mistakes using first carrier fringes to assure that the loads are within the measuring capabilities of the in-plane interferometer and the Carré phase-stepping method to compensate for linear phase step miscalibration. The experimental results obtained with the calibration of loading forces and axial loading verification show the advantages of the system proposed here over a system which uses a cantilever configuration to make a similar bone deformation analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Axial loading verification method for small bones using carrier fringes in speckle pattern interferometry

Dávila

Marquez

Landgrave

et al. 2015

Journal of Modern Optics

Self Cite

View full text Add to dashboard Cite

show abstract

“…This result suggests that the longer coil-sensor distance, the smaller the geometric difference in PEMF strength, particularly in terms of the uniformity of the stimulated area (i.e., a decrease in focality) at distances >40 mm. Testing the influence of PEMF stimulation on bone tissue in vivo [6,7,11], stimulation conditions with lower spatial focality would be preferable to achieve approximately equal PEMF strength throughout the whole marrow cavity with bone marrow in long bones. To the best of our knowledge, this is the first study investigating PEMF strength based on the measurements in marrow cavity in long bones under 810 stimulation conditions.…”

Section: Discussionmentioning

confidence: 99%

Magnetic field strength properties in bone marrow during pulsed electromagnetic stimulation

Tamaki¹,

Yotani²,

Yuki³

et al. 2010

JBiSE

View full text Add to dashboard Cite

We clarified the characteristics of pulsed electromagnetic field (PEMF) strength in marrow cavity with bone marrow in long bones based on actual measurements taken during pulsed magnetic stimulation (PMS). Measurements were made under 810 different conditions of stimulation intensity, distance, and position. Significant and strong linear correlations were observed between PEMF strength and stimulation intensity. PEMF strength in marrow cavity during PMS showed an exponential decay depending on coil-sensor distance, with a breaking point at approximately 30 mm. PEMF strength distributions in bone showed geometric differences between 3 types. These findings suggest that PEMF strength in bone depends on stimulation intensity, distance and horizontal position. Our actual measured data could be useful in determining stimulation programs and estimating the in vivo efficacy of PEMF in marrow cavity for research and clinical use.

show abstract

“…9 The temporal bone was carefully dissected and separated from skull bones, and decalcification of the temporal bone was performed using 8% HCL and 8% formic acid for 3 days. 38 All temporal bones underwent tissue processing and were embedded in paraffin wax. The paraffin blocks were cut into a 25 μm thickness serial section and the external acoustic meatus axis by a microtome (Microme, Germany).…”

Section: ■ Materials and Methodsmentioning

confidence: 99%

Controversial Role of Folic Acid on Diabetic Auditory Neuropathy

Doostkam

Mirkhani

Iravani

et al. 2022

ACS Pharmacol. Transl. Sci.

View full text Add to dashboard Cite

Objective: Diabetic auditory neuropathy (DAN) is a common complication of diabetes that seriously affects the quality of life in patients. In this study, we investigate the role of folic acid in the treatment of DAN in an experimental rat model. Methods: Thirty-two Sprague–Dawley rats were equally divided into four groups: group 1, normal; group 2, diabetic rats; and groups 3 and 4, diabetic rats treated with folic acid (40 and 80 mg/kg, respectively). We used some tools to investigate the therapeutic effect of folic acid on DAN. We evaluated auditory brain stem response (ABR), estimated the volume and number of spiral ganglion and the volume of stria vascularis and spiral ligament by the stereological method, and measured the blood levels of homocysteine (HCY), malondialdehyde (MDA), and superoxide dismutase (SOD). Results: Our study showed that folic acid treatment was not significantly effective in improving structural and functional disorders in DAN, even though its effectiveness in reducing HCY (P < 0.001) and MDA (P < 0.05) as oxidative biomarkers was significant. Conclusion: Folic acid is not effective in relieving morphological and functional disorders in DAN.

show abstract

Pulsed electromagnetic fields induced femoral metaphyseal bone thickness changes in the rat

Cited by 17 publications

References 25 publications

Axial loading verification method for small bones using carrier fringes in speckle pattern interferometry

Axial loading verification method for small bones using carrier fringes in speckle pattern interferometry

Magnetic field strength properties in bone marrow during pulsed electromagnetic stimulation

Controversial Role of Folic Acid on Diabetic Auditory Neuropathy

Contact Info

Product

Resources

About