Pulsed laser-deposited hopeite coatings on titanium alloy for orthopaedic implant applications: surface characterization, antibacterial and bioactivity studies

Abstract

Although titanium and its alloys hold a significant position as an implant material for orthopedic and dental applications, they exhibit limited osteogenic and protective performance. The present research aims to develop an alternate process route for deposition of hopeite coatings on Titanium Grade 5 alloy (Ti-6Al-4V), using the pulsed laser deposition (PLD) technique. SEM, AFM and XRD were used to characterize and ellipsometer and tensometer were used to test the thickness and adhesive strength of the deposited hopeite coatings. While the FACS technique was used to assess their antibacterial activity, the simulated body fluid immersion test was utilized to ascertain their bioactivity. Lastly surface wettability and corrosion resistance of the hopeite coatings were evaluated using contact angle goniometer and potentiostat/galvanostat potentiodynamic (model PARSTAT 2263, Princeton Applied Research, USA), respectively. The PLD technique resulted in the deposition of hopeite coatings with desired crystallinity, adhesive strength of (16.52 ± 1.8 MPa), bioactivity, hydrophobic surface (water contact angle = 135°), superior corrosion resistance (R p = 34,138.68 Ω cm 2) and average surface roughness of (7.43 nm), which is likely to promote better osseointegration. The promising biological characteristics obtained in this research confirmed that the PLD hopeite coatings could be potentially used in orthopaedic implant applications.

Review of Various Hydroxyapatite Coating Methods on SS316L Foam for Biomedical Application

“…Numerous surface modifications techniques of metallic implants were utilised to offers novel approaches in enhancing its clinical versatility [111][112][113][114]. A widely known method adopted for metallic orthopaedic application to promote bone regeneration on metallic implants is to create a composite coating comprising bioceramic components on their surface [115][116][117]. PLD is a coating technology used to coat various substrates employing highly accelerated laser beams in the vacuum environment [118][119][120].…”

Multifunctional hydroxyapatite and hopeite coatings on SS254 by laser rapid manufacturing for improved osseointegration and antibacterial character: A comparative study

“…57 Specimen preparation and procedure for conducting the test implemented in this examination were followed precisely, as specified by the authors. [58][59][60][61][62] FACS results are shown in Figure 6(a)-(c) in terms of the relative data of the death of E. coli, that is, 28.9% and 46.7% for the HA-and hopeite-coated SS254 specimen, respectively, compared to the pristine SS254 specimen. The obtained results ensure the death of E. coli's in the presence of HA-and hopeite-coated specimens.…”

Novel Bioactive Magnesium-Hopeite composite by friction stir processing for orthopedic implant applications

“…It revealed that the Mg-Zn-Mn composite's corrosion resistance and mechanical properties were superior to pure Mg. Similarly, due to the presence of phosphate, a key component of osteoconductive ceramics, and zinc, a wellknown element for improving biomineralization, Das and Shukla, [33][34][35][36] suggested bio-ceramic Hopeite (hydrated zinc phosphate) coating can minimize the release of harmful ions from titanium alloy surfaces and improve overall bioactivity. Hopeite (Zn 3 (PO 4 ) 2 .4H 2 O or hydrated Zinc Phosphate) is a bioimplant substance that accelerates bone development and is typically used in dental implants.…”

“…In the SBF environment, an HA-like layer forms on the surface of bioactive materials, according to previous research, while the bulk remains unchanged. As a result, Hopeite coating on metallic implants, [33][34][35][36] including titanium alloys, is projected to improve overall biological activity. This study aims to create a novel Mg-Hopeite composite using FSP and mark it as novel research where the second phase is Hopeite.…”