Pulsed Radiofrequency Attenuates Complete Freund’s Adjuvant–Induced Epigenetic Suppression of Potassium Chloride Cotransporter 2 Expression

Liu, Chia Kai; Liao, Wen Tzu; Chu, Yu Chi; Yang, Chao‐Hsun; Chen, Kuan Hung; Wu, Chih-Hung; Lin, Chung Ren

doi:10.1093/pm/pnw243

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…Recent studies have found that PRF can produce neuromodulation and relieve trigeminal PHN (Ding et al, 2019). It has been found that PRF can inhibit the nociceptive-induced release of excitatory neurotransmitters (Huang et al, 2016), reduce the expression of calcitonin gene-related peptide (CGRP) in DRG (Ren et al, 2018), inhibit the expression of P2 × 3 receptor in DRG and spinal dorsal horn (Fu et al, 2019), and reduce the expression of peripheral of pro-inflammatory cytokines (TNF-α and IL-6) and β-Catenin in spinal cord (Vallejo et al, 2013;Jiang et al, 2019); At the same time, PRF can up-regulate GDNF transcription and translation (Jia et al, 2016;Hailong et al, 2018), up-regulate GABAB-R1, Na/K ATPase and 5-HT3r gene expression (Vallejo et al, 2013), increase histone acetylation and KCC2 expression by modifying KCC2 and partially restored GABA synaptic function (Liu et al, 2017). The effect of neuromodulation is slow, so cervical nerve root PRF combined with nerve block was used.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Ding

Hong

et al. 2020

Front. Neurosci.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Ding

Hong

et al. 2020

Front. Neurosci.

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“…PRF inhibited the excitatory neurotransmitter (glutamate) induced by nociception and then induced an analgesic effect on neuropathic pain (Huang et al, 2016). PRF increased histone acetylation and potassium-chloride cotransporter 2 (KCC2) expression, partially restored GABA synaptic function, alleviated inflammatory pain sensitization (Liu et al, 2017), and attenuated JNK activation in the spinal dorsal horn (Chen et al, 2014). Therefore, PRF effectively relieves pain, and can be maintained over an extended period of time.…”

Section: Discussionmentioning

confidence: 99%

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

Ding

Yao

et al. 2019

Front. Neurosci.

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Objective: Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, manifesting as a persistent, spontaneous, knife-like pain or paroxysmal burning that seriously affects a patient’s quality of life. An effective treatment of PHN is lacking. This retrospective study examined the efficacy and safety of stellate ganglion (SG) pulsed radiofrequency (PRF) on facial and upper limb PHN.Methods: Eighty-four patients with PHN on the face or upper limbs were enrolled for the study. Patients were randomly divided into two surgical groups according to the order of enrollment; one group underwent SG block (SG-B group, n = 42) and the other underwent SG pulsed radiofrequency (SG-P group, n = 42). After surgery, patients were followed at 1 week, 2 weeks, 1 month, 3 months, and 6 months. Observation at each follow-up included basic patient characteristics, visual analog scale (VAS), quality of life (QOL) using Physical Component Summary (PCS), and Mental Component Summary (MCS) to assess, total effective rate, complications and side effects.Results: Compared with preoperative values, VAS decreased in both groups after surgery (P < 0.05). In the SG-B group, VAS increased after 1 month, while in the SG-P group, VAS gradually decreased at later follow-up time points. VAS decreased more significantly in the SG-P group after 1 month (P < 0.05). PCS and MCS increased in both groups after the operation, and the difference was significant compared with preoperative values (P < 0.05). The total effective rates of the SG-B and SG-P groups were 64.3 and 83.3%, respectively. The total effective rate of the SG-P group was higher than that of the SG-B group (P < 0.05). The incidence of complications and side effects in the SG-B group was higher than that in the SG-P group (P < 0.05).Conclusion: SG pulsed radiofrequency treatment of facial and upper limb PHN is safe and effective. It is a treatment method worth promoting.

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“…100,101 In addition, epigenetic modification of KCC2 gene expression modulated by histone acetylation affects efficacy of GABAergic inhibitory neurotransmission in the spinal dorsal horn. 102 GABAergic plasticity: A potential target for neuropathic pain treatment…”

Section: Epigenetic Etiologies Of Gabaergic Plasticity In Neuropathic Painmentioning

confidence: 99%

The etiological contribution of GABAergic plasticity to the pathogenesis of neuropathic pain

Lei

Tian

et al. 2019

Mol Pain

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Neuropathic pain developing after peripheral or central nerve injury is the result of pathological changes generated through complex mechanisms. Disruption in the homeostasis of excitatory and inhibitory neurons within the central nervous system is a crucial factor in the formation of hyperalgesia or allodynia occurring with neuropathic pain. The central GABAergic pathway has received attention for its extensive distribution and function in neural circuits, including the generation and development of neuropathic pain. GABAergic inhibitory changes that occur in the interneurons along descending modulatory and nociceptive pathways in the central nervous system are believed to generate neuronal plasticity, such as synaptic plasticity or functional plasticity of the related genes or proteins, that is the foundation of persistent neuropathic pain. The primary GABAergic plasticity observed in neuropathic pain includes GABAergic synapse homo- and heterosynaptic plasticity, decreased synthesis of GABA, down-expression of glutamic acid decarboxylase and GABA transporter, abnormal expression of NKCC1 or KCC2, and disturbed function of GABA receptors. In this review, we describe possible mechanisms associated with GABAergic plasticity, such as central sensitization and GABAergic interneuron apoptosis, and the epigenetic etiologies of GABAergic plasticity in neuropathic pain. Moreover, we summarize potential therapeutic targets of GABAergic plasticity that may allow for successful relief of hyperalgesia from nerve injury. Finally, we compare the effects of the GABAergic system in neuropathic pain to other types of chronic pain to understand the contribution of GABAergic plasticity to neuropathic pain.

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Pulsed Radiofrequency Attenuates Complete Freund’s Adjuvant–Induced Epigenetic Suppression of Potassium Chloride Cotransporter 2 Expression

Cited by 6 publications

References 24 publications

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

Efficacy of Pulsed Radiofrequency to Cervical Nerve Root for Postherpetic Neuralgia in Upper Extremity

CT-Guided Stellate Ganglion Pulsed Radiofrequency Stimulation for Facial and Upper Limb Postherpetic Neuralgia

The etiological contribution of GABAergic plasticity to the pathogenesis of neuropathic pain

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