aim: Back pain, the most prevalent musculoskeletal chronic pain condition, is usually treated with analgesic medications of questionable efficacy and frequent occurrence of adverse side effects. objective: The objective was to determine the effectiveness of the ActiPatch medical devices in reducing chronic back pain, document medication related adverse side effects and establish their impact on quality of life. methods: Upon completing a 7-day trial, subjects were contacted via email with an assessment form using the Constant Contact email program. A total of 1394 responses were collected from subjects who used the device for back pain. Conclusion: Medication adverse effects are common and impact quality of life in the lay population. ActiPatch is an effective intervention for the majority of subjects for treating chronic back pain, although this requires further investigation in randomized clinical trials. • Subjects in this study had chronic back pain (CBP), with a mean pain duration averaging 6.1 years.• Pain etiologies demonstrated a heterogeneous subject population of CBP sufferers.• About 96% of the subjects were using analgesics medications averaging 2.5 per subject, with 71% using prescription analgesics.• The majority of individuals using analgesic medications for CBP report less than adequate pain relief.• Adverse effects from pain medications are common (66%) for CBP sufferers.• CBP sufferers, who report chronic pain for longer than 2 years, also detail using approximately 25% more prescription analgesics than those who have experienced the pain for less than 2 years.• The number of adverse effects is directly proportional to the number of prescription analgesics being used.• The increase in the number of adverse side effects negatively impacts quality of life.• The majority of CBP users, upon using the ActiPatch®, reported a clinically significant reduction in pain within 7 days.• Nearly 50% of the study subjects were able to eliminate or decrease analgesic medications after 7 days of use of the medical device.• The ActiPatch was effective in reducing CBP for the majority of subjects as well as reducing their analgesic use.For reprint orders, please contact: reprints@futuremedicine.com