Pulsed radiofrequency stimulation suppresses palmar hyperhidrosis in an animal study

Lin, Ming-Fa; Huang, Tzu-Rung; Kao, Ming‐Chien; Chiu, Hsien‐Tang; Lin, Song–Shu; Chang, Fang‐Chia

doi:10.1002/brb3.833

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Radiofrequency stimulation: A recent study performed by Lin et al in 2017 used pulsed radiofrequency stimulation at the T2 sympathetic trunk in rats. 53 A significant reduction in palm humidity of the treated side was observed in rats who underwent treatment. 53 As a result, radiofrequency stimulation represents a potential reversible treatment option for PH, which may reduce the potential for permanent compensatory sweating.…”

Section: Emerging Treatments For Phmentioning

confidence: 94%

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A Practical Approach to the Diagnosis and Treatment of Palmar Hyperhidrosis

Solish

Savinova²,

Weinberg

2022

Plastic and Reconstructive Surgery - Global Open

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Background: Palmar hyperhidrosis (PH), a condition characterized by excess sweating of the palms, is a common concern that presents to the plastic surgeon, which can have major impacts on patient confidence and quality of life. While several studies summarize treatment options for hyperhidrosis in general, few outline the therapeutic options available specifically for PH. Method: The authors reviewed the current literature specific to the diagnostic workup and treatment of PH. Results: In this article, we show a practical approach to managing patients presenting with PH, summarize its main nonsurgical and surgical treatment options, provide a suggested treatment ladder, and outline emerging therapeutic approaches. We suggest that, after diagnosing PH and classifying its severity, nonsurgical treatments (ie, topical antiperspirants, iontophoresis, botulinum toxin A injection, and topical/oral anticholinergics) should be utilized in a stepwise manner. In patients with severe palmar hyperhidrosis who do not respond to nonsurgical treatments, surgical intervention may be warranted, generally in the form of sympathetic denervation. Conclusion: This article provides a clear overview of PH treatment options, stepwise guidelines for physicians, and educational video resources demonstrating botulinum toxin A injections with cryotherapy and nerve blocks.

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Section: Emerging Treatments For Phmentioning

confidence: 94%

“… 53 As a result, radiofrequency stimulation represents a potential reversible treatment option for PH, which may reduce the potential for permanent compensatory sweating. 53 Further research, including clinical trials, is necessary to elucidate the efficacy of this treatment option in humans.…”

Section: Emerging Treatments For Phmentioning

confidence: 99%

A Practical Approach to the Diagnosis and Treatment of Palmar Hyperhidrosis

Solish

Savinova²,

Weinberg

2022

Plastic and Reconstructive Surgery - Global Open

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“…Another PRF application was reported by Lin et al [ 57 ]. PRF was applied in the T2 ganglion, showing a modulation of the effect of palmar hyperhidrosis, including a 63.6% reduction in sweating.…”

Section: Reviewmentioning

confidence: 99%

Elucidating the Mechanisms of Pulsed Radiofrequency for Pain Treatment

De la cruz,

Benzecry Almeida,

Silva Marques

et al. 2023

Cureus

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Pulsed radiofrequency is a well-documented treatment option for multiple painful conditions where pulses of energy are delivered close to neural elements. Since its earliest adoption, this technique has gained increasing acceptance as a minimally invasive procedure, and new applications are evolving. Studies have shown microscopic and biochemical changes that reflect beneficial effects; however, the exact mechanism of action is not yet completely understood. To redress this paucity, 11,476 articles of scientific relevance published between 1980 and November 2022 were mined through a search of the PubMed database, arriving at 49 studies both in animals and humans. In general, the experimental studies examined have shown that pulsed radiofrequency induces multiple changes with antinociceptive and neuromodulatory effects. These modifications include changes in neural and glial cells, synaptic transmission, and perineural space. Studies also reveal that pulsed radiofrequency regulates inflammatory responses, cellular signaling proteins, and the expression of genes related to pain transmission, acting in biological processes in structures such as myelin, mitochondria, axons, glial cells, connective tissue, regulation of proteins, ion channels, and neurotransmitters.

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