Pulsed Ultrasound Modulates the Cytotoxic Effect of Cisplatin and Doxorubicin on Cultured Human Retinal Pigment Epithelium Cells (ARPE-19)
Seyed Omid Mohammadi,
Megan C. LaRocca,
Christopher D. Yang
et al.
Abstract:Objective: Pulsed ultrasound has been proposed as a tool to enhance ocular drug delivery, but its effects on drug potency are not well understood. Doxorubicin-HCl and cisplatin are two drugs commonly used to treat ocular melanoma. We report the effects of pulsed ultrasound on the cytotoxicity of doxorubicin-HCl and cisplatin in vitro. Methods: Cultured human retinal pigment epithelium cells (ARPE-19) were treated with doxorubicin-HCl or cisplatin in the presence or absence of ultrasound. MTT and Trypan blue as… Show more
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