Pulseless Disease

G, Birke; Ejrup, B; Olhagen, B

doi:10.1177/000331975700800507

Cited by 45 publications

(3 citation statements)

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“…In a case report, Shimizu and Sano found a history compatible with tuberculosis, tuberculoid changes in the aorta or its branches have been found in isolated cases [43-46]. Other studies have reported convincing data of tuberculosis in up to 20% of TA cases [47], whereas in a more recent report scarce convincing evidence was found [39], whereas another report indicates that they occur simultaneously [42].…”

Section: Discussionmentioning

confidence: 99%

Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovisin the aortic tissue of patients with Takayasu’s arteritis

et al. 2012

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BackgroundTakayasu’s arteritis (TA) is a chronic inflammatory disease affecting the large arteries and their branches; its etiology is still unknown. In individuals suffering from TA, arterial inflammation progresses to stenosis and/or occlusion, leading to organ damage and affecting survival. Relation of TA with Mycobacterium tuberculosis has been known, but there have been only a few systematic studies focusing on this association. The IS6110 sequence identifies the Mycobacterium tuberculosis complex and the HupB establishes the differences between M. tuberculosis and M. bovis. Our objective was to search the presence of IS6110 and HupB genes in aorta of patients with TA.MethodsWe analyzed aorta tissues embedded in paraffin from 5760 autopsies obtained from our institution, we divided the selected samples as cases and controls; Cases: aortic tissues of individuals with Takayasu’s arteritis. Control positive: aortic tissues (with tuberculosis disease confirmed) and control negative with other disease aortic (atherosclerosis).ResultsOf 181 selected aorta tissues, 119 fulfilled the corresponding criteria for TA, TB or atherosclerosis. Thus 33 corresponded to TA, 33 to tuberculosis (TB) and 53 to atherosclerosis. The mean age was 22 ± 13, 41 ± 19, and 57 ± 10, respectively. IS6110 and HupB sequences were detected in 70% of TA tissues, 82% in tuberculosis, and in 32% with atherosclerosis. Important statistical differences between groups with TA, tuberculosis versus atherosclerosis (p = 0.004 and 0.0001, respectively) were found.ConclusionWe identified a higher frequency of IS6110 and HupB genes in aortic tissues of TA patients. This data suggests that arterial damage could occur due to previous infection with M. tuberculosis.

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Section: Discussionmentioning

confidence: 99%

Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovisin the aortic tissue of patients with Takayasu’s arteritis

et al. 2012

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“…Takayasu's disease is rare and of unknown aetiology. It appears to occur predominantly in young orientals, although a number of cases outside the orient have been described (Ask-Upmark, 1954;Birke et al, 1957;Koszewski, 1958 ;Wickbom, 1957). Females predominate, the sex ratio being 10 to 20:l (Riehl, 1963).…”

Section: Historymentioning

confidence: 99%

“…Chia (1959) and Sandring and Welin (1961) think that it may be closely related to rheumatic disease. Birke et al (1957) think that causes may differ in different cases. De Bes (1955) postulates a dysontogenetic basis.…”

Section: Clinical Coursementioning

confidence: 99%