Pump Failure: Role of Vasopressor Agents

Reddy, C.V.R.; El‐Sherif, Nabil

doi:10.1016/b978-0-12-238045-7.50009-1

The Pathophysiology and Pharmacotherapy of Myocardial Infarction 1986

DOI: 10.1016/b978-0-12-238045-7.50009-1

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Pump Failure: Role of Vasopressor Agents

C.V.R. Reddy¹,

Nabil El‐Sherif²

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1993

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References 142 publications

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Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function

Zeppellini

Bolognesi²,

Javernaro

et al. 1993

Cardiovasc Drug Ther

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The beneficial effects of dobutamine on left ventricular systolic and diastolic phases have been described in patients with congestive heart failure. Its influence on left ventricular diastolic phase in patients with preserved systolic function, absence of dys- or akinetic areas, and left ventricular dilatation has not yet been adequately investigated. Thus a simultaneous echo-Doppler and hemodynamic study was performed in 15 patients with ischemic heart disease and preserved systolic function in order to assess the effect of dobutamine on left ventricular relaxation and filling phase. The infusion of dobutamine at a rate of 10 micrograms/kg/min induced a marked inotropic action, as shown by the significant increase in positive dP/dt (from 1392 +/- 224 to 2192 +/- 295 mmHg/sec, p < 0.001), dP/dt/P (from 32 +/- 8.1 to 50 +/- 17 sec-1; p < 0.0001), and in peak of systolic pressure (from 143 +/- 25 to 168 +/- 36 mmHg; p < 0.005). In addition, dobutamine reduced the end-systolic volume index (from 30 +/- 16 to 26 +/- 19 ml/m2; p < 0.05), the end-systolic stress (from 222.2 +/- 65.3 to 198.4 +/- 84 g/cm2; p < 0.006), and had favorable effects on relaxation and the early filling phase.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function

Zeppellini

Bolognesi²,

Javernaro

et al. 1993

Cardiovasc Drug Ther

View full text Add to dashboard Cite

show abstract

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Pump Failure: Role of Vasopressor Agents

Cited by 1 publication

References 142 publications

Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function

Effect of dobutamine on left ventricular relaxation and filling phase in patients with ischemic heart disease and preserved systolic function

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