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ACS Paragon Plus Environment LangmuirWe numerically investigate the behavior of a droplet spreading on a smooth substrate with multiple obstacles. As experimental works have indicated, the macroscopic contact line, or three-phase boundary line, of a droplet exhibits a significant deformation resulting in a local acceleration by successive interactions with an array of tiny obstacles settled on the substrate (Mu et al., Langmuir 35, 2019). We focus on the menisci formation and resultant pressure and velocity fields inside a liquid film in a two-spherical-particle system to realize an optimal design of the effective liquid transport phenomenon. Special attention is paid to the meniscus formation around the second particle, which influences the liquid supply related to the pressure difference around the first particle as a function of the distance between the two particles.