Punica granatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment

González, Julio César Rodríguez; Hernández, René Delgado; Berghe, Wim Vanden

doi:10.1007/978-3-030-39855-2_13

Cited by 2 publications

(1 citation statement)

References 221 publications

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“…Due to high incidence and mortality rates of different types of malignancies, cancer is still one of the main challenges in all human societies. 1 Gastric cancer (GC) is one of the common malignancies in digestive system, the fifth most commonly diagnosed cancer, which remains the fourth leading cause of cancer-related death worldwide. 2,3 Despite advances in the treatment of GC, which are mainly based on chemotherapy and radiotherapy methods, drug resistance and high rate of side effects are still major challenges in improving this deadly disease in the clinic.…”

Section: Introductionmentioning

confidence: 99%

The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

et al. 2022

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Although surgery with or without (neo)adjuvant chemo/radiotherapy, as the standard treatments, can be suitable therapeutic strategies for gastric cancer, side effects and drug resistance are two main treatment obstacles. It has been discovered that pomegranate and its natural derivatives, especially ellagic acid (EA), offer significant anti-cancer effects while causing trivial side effects. In this study, we aimed to explore the anti-cancer effects of EA on a human gastric adenocarcinoma cell line (AGS) as well as in immunocompromised mice bearing human gastric tumors, for the first time. HPLC was used for determining EA in samples. MTT assay, apoptosis and scratch assay, gelatin zymography, and quantitative RT-PCR were used to determine the anti-cancer properties of different concentrations of pomegranate fruit juice, pomegranate peel extract, and EA. Furthermore, the effects of these compounds were investigated on immunosuppressed C57BL/6 mice carrying human gastric cancer tumors. EA could inhibit the proliferation and migration of gastric cancer cells. It also had significant effects on reducing both expression and activity of MMP-2 and MMP-9. Further, it was demonstrated that with alterations in the expression of genes involved in apoptosis and inflammation including P53, BAX, APAF1, BCL2, iNOS, NF-κB, IL-8, and TNF-α, EA treatment led to increased cancer cell death and reduced inflammation. Furthermore, its use in mice bearing gastric tumors resulted in a significant reduction in tumor volume without any obvious side effects. Ellagic acid exhibited anti-cancer effects on gastric adenocarcinoma, and can be considered as a safe anti-cancer agent for further preclinical studies on this cancer.

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Section: Introductionmentioning

confidence: 99%

The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

et al. 2022

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Phytochemicals and Therapeutic Potential of Pomegranate

Niazi,

Maooz Awan,

Fatima

et al. 2023

PJHS

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A significant source of polyphenolic chemicals is the pomegranate (Punica granatum). Due to the several pharmacological functions attributed to its phytochemicals, it has been gaining importance. An extensive list of the phytoconstituents present in pomegranate fruits, peel, blossoms, and seeds as well as their pharmacological actions were the goals of this in-depth analysis. The flavonoids and tannins (gallotannin and ellagitannin), which are the active phytochemicals in pomegranate extract, are what give it its anti-inflammatory, antioxidant, anti-angiogenic, and anti-aging qualities. Pomegranate bioactive components are used industrially to create foods with additional value. Wide-ranging applications for its reducing properties in the creation of nano formulations. Its phytoconstituents may play a safer role in managing environmental contamination than the use of pesticides or other chemicals. The numerous human clinical investigations assessing its pharmacological importance have received special attention.

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Punica granatum L. Constituents for Cancer Prevention, Chemosensitisation and Therapeutic Treatment

Cited by 2 publications

References 221 publications

The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells

Phytochemicals and Therapeutic Potential of Pomegranate

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