Punicalagin and Punicalin Suppress the Adipocyte Differentiation through the Transcription Factors

Berköz, Mehmet; Yalın, Serap; Yıldırım, Metin; Yalın, Ali Erdinç; Çömelekoğlu, Ülkü

doi:10.4183/aeb.2021.157

Cited by 4 publications

(3 citation statements)

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“…Muell. ), tropical almond, and their pericarp (peel) (Terminalia catappa L.) [ 17 , 18 ]. The anticancer activity of PNG as well as PN was revealed in numerous cell lines of cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, PN and PNG influence NF-κB signaling through the active phosphorylated form of IκBα prevention and inhibition of translocation of NF-κB-p65 to the cancer cells’ nucleus [ 3 , 17 , 20 , 21 ]. Moreover, Berkoz et al [ 18 ] and Abd-Rabou et al [ 5 ] reported that both of PNG and PN have substantial antioxidant activities. Polyphenols have been reported to increased the uptake of zinc in addition to expression of caco-2 cells metallothionein (MT).…”

Section: Discussionmentioning

confidence: 99%

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An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells

Abdrabou

Shalby

Kotob

2023

Cell Biochem Biophys

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Colorectal cancer is associated with significant morbidity and mortality worldwide. Egypt, as a developing country, has a high-rise incidence of cancer. The current study objective was to investigate the antitumor influences of ellagitannin-loaded CS-PEG-decorated PLGA nano-prototypes against human colorectal cancer cell lines (HCT 116 as well as Caco-2) in vitro. Doxorubicin (DOX), punicalin (PN), and punicalagin (PNG)-encapsulated chitosan-polyethylene glycol-decorated PLGA (PLGA-CS-PEG) nanoparticles (NPs) were described. The cytotoxicity of each preparation was evaluated using MTT assays in HCT 116 as well as Caco-2 cells during G0, G1, S, and G2 cell cycle phases. Cell cycle-related gene expression and protein levels were measured after treatment. Reactive oxygen species (ROS) levels were also measured. Both PN and PNG PLGA-CS-PEG NPs induce colon cancer cell death with cell cycle arrest in the G1 phase in vitro. Caco-2 cells were more sensitive to the nano-therapy than HCT 116 cells. Upon treatment, the ratio of Bax to Bcl-2 expression was increased following nano-therapy, with increased levels of Cas-3 and decreased expression of Bcl-2, PI3k, and NF-ĸB compared to control. The nitric oxide level (NO), a marker of ROS, was increased following nano-therapy compared to control. In conclusion, ROS-mediated cell cycle arrest can be induced by PN as well as PNG nano-therapy in cell lines of colorectal cancer.

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“…Muell. ), tropical almond, and their pericarp (peel) (Terminalia catappa L.) [ 17 , 18 ]. The anticancer activity of PNG as well as PN was revealed in numerous cell lines of cancer.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells

Abdrabou

Shalby

Kotob

2023

Cell Biochem Biophys

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“…As a rich source of polyphenols, including phenolic acids, flavonoids, and tannins, PP was reported to have a broad range of biological activities and health-promoting benefits, such as antioxidant, antimicrobial, anti-inflammatory, antimutagenic, and apoptotic [ 6 , 7 , 8 , 9 , 10 , 11 ]. The most abundant bioactive compounds are ellagitannins, including punicalagin and punicalin, gallic acid, and ellagic acid, which were demonstrated to have various protective effects on the human body and have a great potential to ameliorate chronic metabolic diseases, including cardiovascular diseases, diabetes, and obesity [ 12 , 13 , 14 ]. In this regard, PP could be used as a promising raw material for the production of extracts with multifunctional physiological effects that can provide auxiliary strategies for the treatment of related human diseases.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals

Radan,

Ćujić Nikolić,

Kuzmanović Nedeljković

et al. 2024

Plants

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Recovering the bioactive components from pomegranate peel (PP) in the fruit-processing industry has attracted great attention in terms of minimizing the waste burden, as well as providing a new source of a multitude of functional compounds. The present study aimed to develop a feasible microencapsulation process of PP extract by using pectin and a pectin/2-hydroxypropyl-β-cyclodextrin (HP-β-CD) blend as coating materials. Microsized powders obtained by a spray drying technique were examined in terms of technological characteristics, exhibiting high powder yield and desirable moisture content, flowability, and cohesive properties. Assuming that the interactions with the used biopolymers occur on the surface hydrophobic domain, their presence significantly improved the thermal stability of the microencapsulated powders up to 200 °C. The health-promoting effects of PP have been associated with its high content in ellagitannins, particularly punicalagin. The obtained PP powders exhibited strong antioxidant and hypoglycemic potential, while an antimicrobial assay revealed their potent activity against Gram-positive bacteria. Additionally, an in vitro release study suggested that the used biopolymers can modify the release of target bioactive compounds, thus establishing a basis for developing an oral-controlled release system. Altogether, biowaste valorization from PP by the production of effective multifunctional microsized powders represents a sustainable way to obtain novel nutraceuticals and/or pharmaceuticals.

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Pomegranate peel ethanolic extract: A promising natural antioxidant, antimicrobial agent, and novel approach to mitigate rancidity in used edible oils

Aljeddani,

ALmoshadak

2024

Open Agriculture

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The recognition of medicinal plants for their ability to enhance human resilience in confronting pathogenic diseases and extending the lifetime of food preservation has been explored throughout history. This study aims to assess the in vitro phenolic content, antioxidant properties, and antimicrobial potential of pomegranate peel extract (PPE) in ethanol. The antimicrobial activity of PPE was evaluated using the agar well-diffusion method, while the total phenolic content was determined using the Folin–Ciocalteu method. The antioxidant capacity was assessed utilizing the 2,2-diphenyl-1-picrylhydrazyl technique. The polyphenolic compounds present in PPE were identified using liquid chromatography–electrospray ionization–tandem mass spectrometry. Furthermore, the ability of PPE to counteract oil deterioration was assessed using four different plant-based oils: corn, olive, sunflower, and soybean. The study results revealed that PPE exhibits significant antioxidant activity, inhibits the growth of bacterial and fungal cells, and provides superior protection against oil oxidation and peroxidation at a concentration of 200 ppm, surpassing the synthetic antioxidant butylated hydroxytoluene. These findings underscore the role of PPE as a valuable natural resource for various applications in the food and pharmaceutical industries. By harnessing the beneficial properties of PPE, it is possible to develop natural and sustainable alternatives to synthetic antioxidants and antimicrobials. This not only contributes to the preservation of food quality and safety but also aligns with the growing demand for clean-label and eco-friendly products. Overall, this study provides valuable insights into the multifaceted benefits of PPE and paves the way for further exploration and utilization of this natural resource in various applications.

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Punicalagin and Punicalin Suppress the Adipocyte Differentiation through the Transcription Factors

Cited by 4 publications

References 0 publications

An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells

An ellagitannin-loaded CS-PEG decorated PLGA nano-prototype promotes cell cycle arrest in colorectal cancer cells

Multifunctional Pomegranate Peel Microparticles with Health-Promoting Effects for the Sustainable Development of Novel Nutraceuticals and Pharmaceuticals

Pomegranate peel ethanolic extract: A promising natural antioxidant, antimicrobial agent, and novel approach to mitigate rancidity in used edible oils

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