Punktuelle Excimerlaserablation des Trabekelwerks

Vogel, Martin; Lauritzen, Kyra

doi:10.1007/s003470050180

Cited by 38 publications

(10 citation statements)

References 10 publications

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“…Neuhann et al [17] and Vogel and Lauritzen [16] reported results at 6 and 7 months, respectively, similar to ours, whereas results reported by other authors [18] were only a little better in a study group also involving eyes affected by cataract and submitted to a combined procedure consisting of ELT and phacoemulsification with intraocular lens implantation.…”

Section: Discussioncontrasting

confidence: 35%

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Efficacy and Safety of ab interno Excimer Laser Trabeculotomy in Primary Open-Angle Glaucoma: Two Years of Follow-Up

Babighian

Rapizzi

Galan³

2006

Ophthalmologica

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Ab interno trabeculotomy was performed using the recently developed XeCl excimer laser in 21 eyes of 21 patients with primary open-angle glaucoma refractory to medical therapy. The patients were followed at the Eye Department of S. Antonio Hospital in Padova, for an average of 25.3 ± 1.3 months. Intraocular pressure (IOP), visual acuity and ocular complications were evaluated. The laser procedure was quick and relatively easy, with minimal manipulation of tissues; complications were clinically insignificant. At the last follow-up, a marked IOP-lowering effect compared to baseline was observed (from 24.8 ± 2.0 to 16.9 ± 2.1 mm Hg; –31.8%, p < 0.0001). Nineteen patients (90.5%) had an IOP lowering of 20% or more; however, 8 of these eyes (38.1%) required additional IOP-lowering medical therapy. The procedure failed in 2 cases (9.5%) despite additional therapy. In conclusion ab interno excimer laser trabeculotomy seems effective to decrease IOP, serves to reduce the number of antiglaucoma medications and is relatively safe, proving to be a promising therapeutic option in glaucoma surgery.

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Section: Discussioncontrasting

confidence: 35%

“…Using this new technique, effective trabeculotomy has been performed in rabbit [14] and human [15,16,17,18] eyes. …”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of ab interno Excimer Laser Trabeculotomy in Primary Open-Angle Glaucoma: Two Years of Follow-Up

Babighian

Rapizzi

Galan³

2006

Ophthalmologica

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“…It was developed to improve the aqueous outflow by creating holes through the anterior meshwork of the inner wall of Schlemm's canal with minimal thermal or necrotic effects on the trabecular meshwork. [31][32][33] Babighian et al 33 compared 2-year IOP outcomes of ELT and 1801 SLT in an RCT for patients with POAG refractory to medical therapy. Eyes treated with ELT resulted in a mean IOP reduction from 25.0±1.9 mm Hg at baseline to 17.6±2.2 mm Hg at 24 months.…”

Section: Slt Vs Excimer Laser Trabeculotomy (Elt)mentioning

confidence: 99%

Selective laser trabeculoplasty (SLT) vs other treatment modalities for glaucoma: systematic review

McAlinden

2013

Eye

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Purpose Systemic review to compare selective laser trabeculoplasty (SLT) to other glaucoma treatment options in terms of their intraocular pressure (IOP)-lowering effect. Methods Searches of the following databases were performed: PubMed, Cochrane Central Register of Controlled Trials, Ovid, EMBASE, metaRegister of Controlled Trials, and ClinicalTrials.gov. Only randomised controlled trials (RCTs) published in peer-reviewed journals comparing SLT to other glaucoma treatment options were considered. The main outcome measure was the change in IOP from baseline. Results An initial search of PubMed identified 23 RCTs with 17 meeting the inclusion criteria. Nine RCTs compared 1801 SLT to 1801 argon laser trabeculoplasty (ALT) and one trial compared 3601 SLT to 3601 ALT, all reporting no difference in terms of IOP reduction from baseline. One RCT reported better outcomes with SLT at 1 year but this effect regressed at 2 years. Three trials compared 3601 SLT to medical therapy and found no difference between the two treatment options. One trial found greater IOP reduction with latanoprost vs 901 and 1801 SLT, and greater IOP reduction with 1801 and 3601 SLT versus 901 SLT, however no differences were found between 3601 SLT versus latanoprost or 3601 vs 1801 SLT. Two trials compared 1801 SLT to 3601 SLT finding no difference in IOP reduction. Two trials compared 1801 SLT to 901 SLT, one finding no significant difference and one finding greater IOP reduction with 1801 SLT over 901 SLT. One trial compared excimer laser trabeculotomy (ELT) to 1801 SLT, finding no differences in IOP reduction up to 3 months follow-up but greater IOP reduction with ELT at time intervals between 9 and 24 months. There were no RCTs identified that compared SLT to surgery. Conclusion In terms of the IOP lowering effect, there is no difference between SLT and ALT. Three trials indicate no difference between 3601 SLT and medical therapy, with one of the trials indicating greater IOP reduction with latanoprost over 901 and 1801 SLT. Three trials indicate no difference between 1801 SLT and 3601 SLT. It is inconclusive whether 901 is less efficacious than 1801 SLT. One trial reports greater IOP reduction with ELT over 1801 SLT in the long term.

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“…Finally, the authors do not propose a hypothesis to explain the progressive decrease in intraocular pressure over time as opposed to other ELT studies in which the decrease in intraocular pressure occurs in the immediate postoperative period and is sustained [4,5] . Do the authors offer any hypothesis as to why their patients have a slower rate of decline than others?…”

mentioning

confidence: 88%

Excimer Laser Trabeculotomy

Taliaferro¹

2008

Ophthalmologica

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Punktuelle Excimerlaserablation des Trabekelwerks

Cited by 38 publications

References 10 publications

Efficacy and Safety of ab interno Excimer Laser Trabeculotomy in Primary Open-Angle Glaucoma: Two Years of Follow-Up

Efficacy and Safety of ab interno Excimer Laser Trabeculotomy in Primary Open-Angle Glaucoma: Two Years of Follow-Up

Selective laser trabeculoplasty (SLT) vs other treatment modalities for glaucoma: systematic review

Excimer Laser Trabeculotomy

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