Pupillary response: cognitive effort for breast cancer survivors

Myers, Jamie; Kahya, Melike; Mitchell, Melissa; Dai, Junqiang; He, Jia; Moon, Sanghee; Hamilton, Kevin; Valla, Mary; O’Dea, Anne; Klemp, Jennifer R.; Kurylo, Monica; Akinwuntan, Abiodun Emmanuel; Devos, Hannes

doi:10.1007/s00520-018-4401-0

Cited by 11 publications

(22 citation statements)

References 35 publications

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“…Likewise, pupillometry has been used for over five decades as a measure of cognitive workload in the domains of psychophysiology, cognitive neuroscience, and human factor engineering, such as aviation or driving. Only recently has pupillometry received attention in the medical field as a potential marker of disease progression in adults with AD, Parkinson’s disease, and breast cancer [ 15 , 21 , 29 , 32 ]. This rekindled interest in pupillary response to cognitive workload as a marker of cognitive decline warrants an investigation of its psychometric properties.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the ICA is claimed to be unaffected by changes in eye movements and sampling rate [ 27 ]. The ICA in particular has been used to investigate changes in cognitive workload in individuals at risk of cognitive impairment, including those with Parkinson’s disease, multiple sclerosis, and breast cancer [ 4 , 28 , 29 , 30 , 31 , 32 ]. Overall, the ICA seems to increase with cognitive demand, regardless of disease condition [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Overall, the ICA seems to increase with cognitive demand, regardless of disease condition [ 29 ]. In addition, some studies report that individuals with increased risk of cognitive impairment show greater ICA compared to controls [ 30 , 32 , 33 ]. However, the reliability and validity of the ICA during working memory tasks in older individuals have not been established.…”

Section: Introductionmentioning

confidence: 99%

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Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

et al. 2020

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Cognitive workload is increasingly recognized as an important determinant of performance in cognitive tests and daily life activities. Cognitive workload is a measure of physical and mental effort allocation to a task, which can be determined through self-report or physiological measures. However, the reliability and validity of these measures have not been established in older adults with a wide range of cognitive ability. The aim of this study was to establish the test–retest reliability of the National Aeronautics and Space Administration Task Load Index (NASA-TLX) and Index of Cognitive Activity (ICA), extracted from pupillary size. The convergent validity of these measures against event-related potentials (ERPs) was also investigated. A total of 38 individuals with scores on the Montreal Cognitive Assessment ranging between 17 and 30 completed a working memory test (n-back) with three levels of difficulty at baseline and at a two-week follow-up. The intraclass correlation coefficients (ICC) values of the NASA-TLX ranged between 0.71 and 0.81, demonstrating good to excellent reliability. The mean ICA scores showed fair to good reliability, with ICCs ranging between 0.56 and 0.73. The mean ICA and NASA-TLX scores showed significant and moderate correlations (Pearson’s r ranging between 0.30 and 0.33) with the third positive peak of the ERP at the midline channels. We conclude that ICA and NASA-TLX are reliable measures of cognitive workload in older adults. Further research is needed in dissecting the subjective and objective constructs of cognitive workload.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Psychometric Properties of NASA-TLX and Index of Cognitive Activity as Measures of Cognitive Workload in Older Adults

et al. 2020

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“…[25] The ICA in particular has been used to investigate changes in cognitive workload in individuals at risk of cognitive impairment, including Parkinson’s disease, multiple sclerosis, and breast cancer. [4 26-30] Overall, the ICA seems to increase with cognitive demand, regardless of disease condition[27]. In addition, some studies report that individuals with increased risk of cognitive impairment show greater ICA compared to controls.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, some studies report that individuals with increased risk of cognitive impairment show greater ICA compared to controls. [28 30 31] However, the reliability and validity of ICA during working memory tasks in older individuals have not been established.…”

Section: Introductionmentioning

confidence: 99%

Reliability and Validity of Cognitive Workload in Older Adults

Devos

Gustafson

Ahmadnezhad

et al. 2020

Preprint

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Cognitive workload or mental effort is a measure of attention allocation to a task, which can be administered through self-report or physiological measures. Cognitive workload is increasingly recognized as an important determinant of performance in cognitive tests and daily life activities. However, the reliability and validity of these measures have not been established in older adults with a wide range of cognitive ability. The aim of this study was to establish the test-retest reliability of the NASA-Task Load Index (NASA-TLX) and Index of Cognitive Activity (ICA), extracted from pupillary size. The convergent validity of these measures against event-related potentials (ERPs) was also investigated. A total of 38 individuals with scores on the Montreal Cognitive Assessment ranging between 17 and 30 completed a working memory test (n-back) with three levels of difficulty at baseline and two-week follow-up. Intraclass correlation coefficients (ICC) values of the NASA-TLX ranged between 0.71 and 0.81, demonstrating good to excellent reliability. Mean ICA scores showed fair to good reliability, with ICCs ranging between 0.56 and 0.73. Mean ICA and NASA-TLX scores showed significant and moderate correlations with Pearson r ranging between 0.30 and 0.33 with P3 ERP at the midline channels. We conclude that ICC and NASA-TLX are reliable measures of cognitive workload in older adults. Further research is needed in dissecting the subjective and objective constructs of cognitive workload.

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