Pupillenweite in Alltagssituationen

Heine, C.; Yazdani, F.; Wilhelm, Helmut

doi:10.1055/s-0033-1350927

Cited by 9 publications

(6 citation statements)

References 6 publications

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“…In line with previous laboratory findings [19–28], our data confirmed that steady-state pupil size decreases with age, even under uncontrolled real-world conditions. In addition, our exploratory results replicate that the effect is stronger in dim compared to bright light conditions [13, 24, 28, 29, 77]. Perhaps the most compelling findings are the consistent linear regression parameters between our data and the laboratory data presented in Figure 2 by Winn et al in 1994 [28].…”

Section: Discussionsupporting

confidence: 84%

Regulation of pupil size in natural vision across the human lifespan

Lazar,

Degen,

Fiechter

et al. 2023

Preprint

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Vision is mediated by light passing through the aperture of the eye, the pupil, which changes in diameter from ~2 to ~8 mm from the brightest to the darkest illumination. In addition, with age, mean pupil size declines. In laboratory experiments, factors affecting pupil size can be experimentally controlled or held constant, but how the pupil reflects changes in retinal input from the visual environment under natural viewing conditions is not clear. Here, we address this question in a field experiment (N=83, 43 female, age: 18-87 years) using a custom-made wearable video-based eye tracker with a spectroradiometer measuring spectral irradiance in the approximate corneal plane. Participants moved in and between indoor and outdoor environments varying in spectrum and engaged in a range of everyday tasks. Our real-world data confirm that light-adapted pupil size is determined by light intensity, with clear superiority of melanopic over photopic units, and that it decreases with increasing age, yielding steeper slopes at lower light levels. We find no indication that sex, iris colour or reported caffeine consumption affect pupil size. Taken together, the data provide strong evidence for considering age in personalised lighting solutions and for using melanopsin-weighted light measures to assess real-world lighting conditions.

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Section: Discussionsupporting

confidence: 84%

Regulation of pupil size in natural vision across the human lifespan

Lazar,

Degen,

Fiechter

et al. 2023

Preprint

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“…The reduction in baseline pupil diameter from the youngest to the oldest age group of 1.45 mm in photCPC and 1.53 mm in scotCPC is in accordance with previous findings of an average of approximately 0.04 mm decrease per year under weak illumination. 27 , 28 This validates our method as precise enough to reproduce such expected effects and serves as a proof-of-concept for a reliable evaluation of pupillary responses and possible influencing factors. It additionally emphasizes the importance of the normalization of the pupillary constriction amplitude to the baseline pupil diameter in PLR evaluation.…”

Section: Discussionsupporting

confidence: 64%

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Jendritza,

Stingl,

Strasser

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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PURPOSE.Investigating influencing factors on the pupillary light response (PLR) as a biomarker for local retinal function by providing epidemiological data of a large normative collective and to establish a normative database for the evaluation of chromatic pupil campimetry (CPC). METHODS.Demographic and ophthalmologic characteristics were captured and PLR parameters of 150 healthy participants (94 women) aged 18 to 79 years (median = 46 years) were measured with L-cone-and rod-favoring CPC protocols. Linear-mixed effects models were performed to determine factors influencing the PLR and optical coherence tomography (OCT) data were correlated with the pupillary function volume. RESULTS.Relative maximal constriction amplitude (relMCA) and latency under L-cone-and rod-favoring stimulation were statistically significantly affected by the stimulus eccentricity (P < 0.0001, respectively). Iris color and gender did not affect relMCA or latency significantly; visual hemifield, season, and daytime showed only minor influence under few stimulus conditions. Age had a statistically significant effect on latency under rodspecific stimulation with a latency prolongation ≥60 years. Under photopic and scotopic conditions, baseline pupil diameter declined significantly with increasing age (P < 0.0001, respectively). Pupillary function volume and OCT data were not correlated relevantly. CONCLUSIONS.Stimulus eccentricity had the most relevant impact on relMCA and latency of the PLR during L-cone-and rod-favoring stimulation. Latency is prolonged ≥60 years under scotopic conditions. Considering the large study collective, a representative normative database for relMCA and latency as valid readout parameters for L-cone-and rodfavoring stimulation could be established. This further validates the usability of the PLR in CPC as a biomarker for local retinal function.

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“…1 Heine et al found that the mesopic pupil size decreased by 0.42 mm per decade in a population of 206 volunteers aged between 18 and 72 years without disorders influencing the pupil. 10 Unlike the well-known bifocal Restor IOL (Alcon, Fort Worth, USA), which shares the same AcrySof IQ platform, the design of the PanOptix does not feature apodization; a varying step height of the diffractive rings with the pupil size. The absence of apodization ensures that the light energy allocation to the three foci is independent of the pupil.…”

Section: Discussionmentioning

confidence: 99%

“…larger pupil diameter, increased healing reaction or incomplete eye growth, need to be considered when using lenses with these optics in pediatric cases. 9 , 10 Furthermore, the possibility of amblyopia should be taken into account. Since multifocal IOLs split the incoming light energy on different foci, a loss in contrast sensitivity might occur.…”

Section: Introductionmentioning

confidence: 99%

Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia

Yildirim

Son

Huber

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo present the case of a 9-year-old child with bilateral posterior subcapsular cataract developed through steroid treatment for acute lymphoblastic leukemia. Cataract surgery with trifocal intraocular lens implantation was performed in both eyes.ObservationsUncorrected distance visual acuity increased from +0.3 and + 0.4 logMAR preoperatively to 0.00 and + 0.04 logMAR after surgery. Binocular uncorrected values for intermediate and near visual acuity were −0.04 logMAR and 0.02 logMAR after surgery, respectively. The patient did not report side effects like halos or glare and was able to participate in his daily activities (school and sports) without spectacles.Conclusions and ImportanceThis report represents the first description of a bilateral implantation of trifocal intraocular lenses in a pediatric cataract case with restoration of visual function in far, intermediate and near distance. Trifocal intraocular lenses to compensate for the loss of accommodation can be an option in selected cases of children with cataract.

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Pupillenweite in Alltagssituationen

Cited by 9 publications

References 6 publications

Regulation of pupil size in natural vision across the human lifespan

Regulation of pupil size in natural vision across the human lifespan

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Bilateral trifocal IOL implantation in a pediatric case of cataract following steroid-therapy for acute lymphoblastic leukemia

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