Pupillometry measures of autonomic nervous system regulation with advancing age in a healthy pediatric cohort

Winston, Molly; Zhou, Amy; Rand, Casey M.; Dunne, Emma C.; Warner, Justin J.; Volpe, L.; Pigneri, Brooke A.; Simon, Drew; Bielawiec, Thomas; Gordon, Samantha; Vitez, Sally F.; Charnay, Aaron; Joza, Stephen; Kelly, Kristen M.; Panicker, Cia; Rizvydeen, Saajidha; Niewijk, Grace; Coleman, Cara; Scher, B.J.; Reed, David W.; Hockney, Sara M; Buniao, Gigi; Stewart, Tracey M.; Trojanowski, Lynne; Brogadir, Cindy D.; Price, Michelle; Kenny, Anna S.; Bradley, Allison; Volpe, Nicholas J.; Weese‐Mayer, Debra E.

doi:10.1007/s10286-019-00639-3

Cited by 25 publications

(25 citation statements)

References 35 publications

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“…Brown et al reported a weak inverse association between age and both MCV and ADV within children. 26 A similar trend in MCV decreasing with increasing age was demonstrated in a more recent pediatric normative study by Winston et al 28 This association with age and MCV has also been found in adults. 29 This suggests that pupillary constriction and dilation velocities would be slowed in older children, which is the opposite of the results of our study, where the concussion cohort that was older in average age had faster constriction and dilation velocities compared to our normative cohort.…”

Section: Discussionsupporting

confidence: 75%

“…It has been shown in other pediatric studies that age correlates with MAX and MIN, increasing quadratically with age. 26 -28 Given that MAX and MIN were similar in our study among the concussion and control cohorts but that age confounds these results, an age-matched study is necessary to determine if there are indeed differences between these parameters. Although pupillary diameter trends with age are well validated, age maturation patterns of dynamic pupillary measures such as ACV, MCV, ADV, and T75 recovery are less robust.…”

Section: Discussionmentioning

confidence: 75%

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Concussion Alters Dynamic Pupillary Light Responses in Children

et al. 2020

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Aim: To investigate the impact of concussion on pupillary function in children by examining pupillometric parameters and assessing for differences in children reporting photosensitivity. Methods: Retrospective chart review was performed of pediatric patients referred for visual symptoms after concussion from 2017 to 2018 seen in a single academic outpatient clinic. Pupillometry data of 92 patients were included. Outcomes were compared to normative pediatric data from the same institution by 2-sample t tests. The association between photosensitivity and each outcome was assessed by use of linear mixed models with photosensitivity as a fixed effect and random patient effect. Results: Outcomes of 181 eyes in 92 concussion patients were averaged by patient and compared to normative values in scotopic conditions. Concussion patients had an average age of 13.8 ± 2.64 years. Average constriction velocity ( P = .0008), maximum constriction velocity ( P = .0012), and average dilation velocity ( P = .0034) were faster in concussion patients, whereas 75% recovery times ( P = .0027) was increased. Photosensitivity did not significantly affect measured pupillary responses. Conclusion: Dynamic pupillary responses may be increased in pediatric concussion. Pupillometry may provide insight into the complex pathophysiological changes underlying pediatric concussion.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 75%

Concussion Alters Dynamic Pupillary Light Responses in Children

et al. 2020

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“…Moreover, it was recently found that pupil size is correlated with measures of HR, considerably controlled by the PSNS and galvanic skin response, an independent index of sympathetic activity [ 46 ]. However, a study suggested that there is a maturation of the pupillary response according to the age and sex among healthy children [ 47 ]. Lastly, we take into consideration different confounders, but we cannot exclude the potential impact from other unmeasured covariates on our findings.…”

Section: Discussionmentioning

confidence: 99%

Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children

et al. 2021

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Evidence about the impact of vegetable and fruit diversity consumption on the autonomic nervous system (ANS) functioning is scarce. In this cross-sectional study (513 participants, 49.9% girls aged 7 to 12 years), we evaluated the association between vegetable and fruit diversity consumption and the ANS in school-aged children. Dietary intake was collected using a single 24-h recall questionnaire. Fruit and vegetable diversity consumption was estimated by summing up all the different individual vegetables and fruits consumed in one day. Pupillometry was used to assess pupillary light response, which evaluated the ANS activity. Adjusted linear regressions estimated the association between vegetable and fruit diversity consumption with pupillary light response measures. There was a positive and significant association between vegetable diversity consumption and the average dilation velocity, a measure related to the sympathetic nervous system activity (β-coefficient = 0.03, 95%CI: 0.002; 0.07). Our findings show that vegetable diversity consumption is associated with the ANS response, a possible early link between diet and health in school-aged children.

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“…A growing body of work shows how pupillometry can be used as a possible biomarker for numerous neurological and psychiatric conditions in early development and adult subjects [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27]. Spontaneous and voluntary modulation of pupil fluctuations have also been used to .…”

Section: Introductionmentioning

confidence: 99%

MEYE: Web-app for translational and real-time pupillometry

Mazziotti

Carrara

Viglione

et al. 2021

Preprint

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Pupil dynamics alterations have been found in patients affected by a variety of neuropsychiatric conditions, including autism. Studies in mouse models have used pupillometry for phenotypic assessment and as a proxy for arousal. Both in mice and humans, pupillometry is non-invasive and allows for longitudinal experiments supporting temporal specificity, however its measure requires dedicated setups. Here, we introduce a Convolutional Neural Network that performs on-line pupillometry in both mice and humans in a web app format. This solution dramatically simplifies the usage of the tool for non-specialist and non-technical operators. Because a modern web browser is the only software requirement, this choice is of great interest given its easy deployment and set-up time reduction. The tested model performances indicate that the tool is sensitive enough to detect both spontaneous and evoked pupillary changes, and its output is comparable with state-of-the-art commercial devices.

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Pupillometry measures of autonomic nervous system regulation with advancing age in a healthy pediatric cohort

Cited by 25 publications

References 35 publications

Concussion Alters Dynamic Pupillary Light Responses in Children

Concussion Alters Dynamic Pupillary Light Responses in Children

Increasing Vegetable Diversity Consumption Impacts the Sympathetic Nervous System Activity in School-Aged Children

MEYE: Web-app for translational and real-time pupillometry

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