Pure Mucinous Breast Carcinoma: A Favorable Subtype

Abstract

Background: Pure mucinous breast carcinoma is a relatively rare subtype of breast malignancy. This study is to investigate the clinical and pathologic features of pure mucinous breast carcinoma. Patients andMethods: A retrospective review of our database of patients who presented with breast cancer was performed. The medical records of 1,060 patients with invasive breast cancer who underwent surgery were reviewed. Results: 28 patients with pure mucinous breast cancer were identified. The mean age was 55.28 ± 15.73 years. 17 patients underwent modified radical mastectomy; 11 underwent breast-conserving therapy. The tumor size was T1 in 19 patients, T2 in 8 patients, and T3 in 1 patient. None of the patients had lymph node metastasis. There was no distant metastasis. 18 were stage I, and 10 were stage II. Estrogen receptor, progesterone receptor, HER-2, and P53 were positive in 96, 93, 0, and 28%, respectively. Median follow-up was 42 months (range 1-84 months). 1 patient had local recurrence. The overall survival rate was 100%. Conclusion: Pure mucinous breast carcinoma has a favorable prognosis. Less invasive treatment might be optional. Larger data samples with longer follow-up would be necessary to gain a better understanding of this disease.

Pure and Mixed Mucinous Carcinoma of the Breast: A Comparison of Clinical Outcomes and Treatment Results

“…All these differences were, however, statistically insignificant; this is in accordance with the data from literature (). In the studied group, patients with MMBC showed a significantly higher incidence of axillary nodal metastases than PMBC; this phenomenon has been confirmed by numerous authors (Table ).…”

“…Beyond a shadow of a doubt, in general, PMBC is accompanied by a low propensity for axillary lymph node metastases and a significantly better prognosis than MMBC (). Only a few studies indicate that long‐term outcomes for PMBC and MMBC are comparable .…”

“…On the other hand, there is an important distinction between PMBC and MMBC in terms of tumor behavior and treatment results; most studies have reported that PMBC has a slower growth rate and has a better prognosis, with a lower frequency of axillary lymph node metastases than MMBC . A number of authors claim that MMBC tends to assume a pattern similar to that of invasive ductal carcinoma in terms of nodal status and prognosis, and suggest that PMBC should perhaps only be regarded as a form of MBC.…”

GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin

“…In light of the knowledge that mucinous breast carcinoma is a lowgrade tumor that usually expresses ERa, that finding was also not unexpected [23].…”

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“…From a histologic perspective, mucinous carcinoma may be divided in pure mucinous and mixed mucinous entities, depending upon the quantification of cellularity. The pure type is very rare and consists exclusively of tumor tissue with extracellular mucin production, whiles the mixed form, also contains an infiltrating ductal epithelial component without mucin [1]. We present the case of a patient with a lung metastasis of a pure mucinous breast carcinoma occurring 20 years after the initial diagnosis.…”