We review the recent progress in studying the quantum structure of 6D, N = (1, 0) and N = (1, 1) supersymmetric gauge theories formulated through unconstrained harmonic superfields. The harmonic superfield approach allows one to carry out the quantization and calculations of the quantum corrections in a manifestly N = (1, 0) 1 way. The quantum effective action is constructed with the help of the background field method that secures the manifest gauge invariance of the results. Although the theories under consideration are not renormalizable, the extended supersymmetry essentially improves the ultraviolet behavior of the lowest-order loops. The N = (1, 1) supersymmetric Yang-Mills theory turns out to be finite in the one-loop approximation in the minimal gauge. Also some two-loop divergences are shown to be absent in this theory. Analysis of the divergences is performed both in terms of harmonic supergraphs and by the manifestly gauge covariant superfield proper-time method. The finite one-loop leading low-energy effective action is calculated and analyzed. Also in the abelian case we discuss the gauge dependence of the quantum corrections and present its precise form for the one-loop divergent part of the effective action.