Pure Squamous Cell Carcinoma of the Duodenum

Battal, Muharrem; Bostancı, Özgür; Başak, Tülay; Kartal, Kinyas; Ekiz, Feza

doi:10.1155/2015/714640

Cited by 10 publications

(8 citation statements)

References 9 publications

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“…This was Squamous cell carcinoma (SCC) of the duodenum. Although rare, primary SCC has been reported in case series 27 . Adenocarcinoma is a more common entity.…”

Section: Clinico-pathological Patternmentioning

confidence: 99%

Clinico-pathological pattern and early post-operative complications of gastro-duodenal perforations at Mulago Hospital Kampala- a prospective cohort study

Nansubuga¹,

Kirunda²,

Wesonga³

et al. 2016

East. Cent. Afr. J. Surg.

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Background: Gastro-Duodenal Perforations are one of the commonest causes of mortality and morbidity in conditions that require emergency surgery. The main objective of this study was to determine the clinico-pathological pattern and evaluate factors for early postoperative complications of Gastro-duodenal perforations in Mulago. Methods: This was a prospective cohort study of patients with gastro-duodenal perforations managed by simple repair between September 2014 and April 2015 in Mulago was studied. Primary/ secondary outcomes were mortality and complications respectively. Data was managed using stata-12 and multivariate analysis using log-binomial regression model. Results: A total of 65 patients were operated for Gastro-duodenal perforations in the study period. 86.2% were male (M: F 6.2:1). Median age was 35 years (range 16-80 years). 93.9% had gastric perforations. Clinical diagnosis was predicted in 89.3%. H. pylori was present in 7.9%. Mortality was 18.5% and complications developed in 58.5%. Age above 35 and presence of co morbidity predicted mortality (CI 1.22-21.12, p= 0.009) (CI 1.26-8.82, p= 0.024) and early post-operative complications (CI 1.03-2.44, p= 0.031) (CI 1.23-2.44, p= 0.011) respectively. Conclusion: Gastroduodenal perforations remain a common surgical emergency in Mulago hospital affecting mainly young men below 35 years. Majority are gastric perforations. Mortality and early post-operative complications are high, and increase with age and presence of co morbidity.

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“…This was Squamous cell carcinoma (SCC) of the duodenum. Although rare, primary SCC has been reported in case series 27 . Adenocarcinoma is a more common entity.…”

Section: Clinico-pathological Patternmentioning

confidence: 99%

Clinico-pathological pattern and early post-operative complications of gastro-duodenal perforations at Mulago Hospital Kampala- a prospective cohort study

Nansubuga¹,

Kirunda²,

Wesonga³

et al. 2016

East. Cent. Afr. J. Surg.

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“…Primary duodenal SCC is exceedingly rare, with only a few cases reported in the literature. 15,16 Most of these cases were tumors in the descending duodenum near the ampulla of Vater. Distinguishing between metastatic SCC and primary duodenal SCC on the basis of symptoms and imaging findings is difficult, because the major findings of the 2 conditions are similar.…”

Section: Discussionmentioning

confidence: 99%

“…Duodenal SCCs have been reported to be more likely metastases from other sites, 14 but determining whether the duodenal SCC is a primary or metastatic tumor is necessary. Primary duodenal SCC is exceedingly rare, with only a few cases reported in the literature 15,16 . Most of these cases were tumors in the descending duodenum near the ampulla of Vater.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic benefit of cytological and histopathological examinations for recurrent vaginal cancer metastasizing to the duodenum: A case report

Sonoda

Okadome

Sugimoto

et al. 2020

Clinical Case Reports

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Metastatic disease from a primary malignancy to the duodenum is extremely rare. Here, we report the first case of a recurrent vaginal squamous cell carcinoma that metastasized to the duodenum. Cytological and histopathological examinations were useful for the diagnosis of a recurrent vaginal cancer metastasizing to the duodenum. Primary vaginal cancer is a rare tumor, making up approximately 1%-2% of all gynecologic cancers and only 10% of all malignant neoplasms involving the vagina. 1 According to Cancer Statistics in Japan-2019, of 157,800 deaths due to female malignant neoplasms, 139 deaths (0.09%) were due to vaginal cancer. 2 Approximately 6,230 new cases of vaginal cancer associated with 1,450 deaths have been estimated for 2020 in the United States. 3 Squamous cell carcinoma (SCC) is the most common histopathological type (85%) followed by adenocarcinoma (10%-15%). 4 A population-based study from Denmark reported that 89% of women with vaginal SCC were positive for high-risk human papillomavirus (HPV). 5 Though vaginal cancer may invade locally and disseminate by hematogenous and lymphatic routes, 4 a metastasis to the duodenum is extremely rare. Only 1 case report of vaginal malignant melanoma with metastasis to the papilla of Vater can be found on PubMed. 6 Herein, we report a case of recurrent vaginal cancer metastasizing to the duodenum, for which cytological and histopathological examinations were useful for obtaining a diagnosis.

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“…Only 7 cases of primary ASC of the ampulla of Vater [ 4 , 5 , 6 , 19 ], 8 cases of primary SCC of the duodenum [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ], and 2 cases of primary SCC of the ampulla of Vater [ 14 , 15 ] have been reported in the medical literature. Clinical characteristics, treatment, and prognosis of all these cases are summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

“…More than 40 histological subtypes of small intestinal malignancies have been described, the most common being adenocarcinoma, sarcoma, lymphoma, and neuroendocrine tumors [ 3 ]. Rare cases of squamous cell carcinoma (SCC) and mixed tumors like adenosquamous carcinoma (ASC) and adenoneuroendocrine tumors have been reported as isolated case reports [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. ASC of the duodenum is an exceedingly rare neoplasm, with only a few cases described in the medical literature.…”

Section: Introductionmentioning

confidence: 99%

Mixed Adenocarcinoma and Squamous Cell Carcinoma of Duodenum: A Case Report and Review of the Literature

Hammami

Chhaparia

Piao

et al. 2017

Case Rep Gastroenterol

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Despite being the largest part of the human gastrointestinal (GI) tract, the small intestine accounts for only 1–1.4% of all GI malignancies. Adenocarcinoma is the most common primary small bowel malignancy, with the most common site being the duodenum. On the other hand, squamous cell carcinoma (SCC) of the duodenum is extremely uncommon. We report the first case of mixed adenocarcinoma and SCC occurring in the third part of duodenum (D3). Our patient, a 64-year-old female with history of GERD, hypertension, and IDDM presented with 4 weeks of nausea, vomiting, and abdominal pain. Tomographic imaging of her abdomen demonstrated a distended stomach and a proximal duodenum with narrow caliber changes at the level of D3. An EGD revealed a tight stricture at D3 that could not be traversed. Stricture biopsies revealed duodenal mucosa with two small foci of SCC (positive for p63 and CK5/6) and adenocarcinoma (positive for CK7 and Moc31). Peritoneal metastases were detected on exploratory laparotomy, making the tumor surgically incurable. As she progressively declined and with worsening liver enzymes and general debility, she was not a candidate for chemotherapy and was eventually discharged on home hospice. Small bowel SCC/adenocarcinoma is an exceedingly uncommon cancer, making further case reports such as ours important to understand the nature of this entity and establish management guidelines.

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Pure Squamous Cell Carcinoma of the Duodenum

Cited by 10 publications

References 9 publications

Clinico-pathological pattern and early post-operative complications of gastro-duodenal perforations at Mulago Hospital Kampala- a prospective cohort study

Clinico-pathological pattern and early post-operative complications of gastro-duodenal perforations at Mulago Hospital Kampala- a prospective cohort study

Diagnostic benefit of cytological and histopathological examinations for recurrent vaginal cancer metastasizing to the duodenum: A case report

Mixed Adenocarcinoma and Squamous Cell Carcinoma of Duodenum: A Case Report and Review of the Literature

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