Pure Testicular Choriocarcinoma with Dermatological, Brain, and Gastrointestinal Metastases

Nassri, Rama; Muftah, Mayssan; Nassri, Ammar; Alkhasawneh, Ahmad; Corak, Jadranko

doi:10.7759/cureus.3083

Cited by 3 publications

(3 citation statements)

References 20 publications

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“…This is caused by early haematogenous spread, with distant lesions often affecting the GI tract, lung and brain. These tumours are associated with local vascular invasion, and thus commonly present with haemorrhagic symptoms such as GI bleed, haemoptysis or cranial/CNS haemorrhage 1–3. As was the case for our patient, the urgency of these haemorrhagic complications and associated morbidity/mortality, may be more pressing than the oncological disease treatment 1 2…”

Section: Discussionmentioning

confidence: 55%

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Head and neck cutaneous metastasis of testicular choriocarcinoma

Shabani¹,

Pritchard

Padhya

et al. 2020

BMJ Case Rep

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Testicular choriocarcinoma (CC) is a malignant germ cell tumour which most frequently presents with disseminated metastasis, often involving the lungs, brain and liver. Metastatic are characterised by extensive vascularity, often causing patients to present emergently with potentially life-threatening haemorrhagic complications. We report a patient with disseminated testicular CC, presenting with haemorrhage from a dermal metastatic focus involving the lower lip and mentum, requiring surgical intervention. This unique case illustrates the potential utility of palliative surgery, for the management of symptomatic metastatic disease, such as those caused by testicular CC.

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Section: Discussionmentioning

confidence: 55%

“…Unusual site of metastasis, such as skin, have been associated with a poor prognosis 3. Head and neck cutaneous metastasis are particularly uncommon, with only four other reported cases in the literature.…”

Section: Discussionmentioning

confidence: 99%

Head and neck cutaneous metastasis of testicular choriocarcinoma

Shabani¹,

Pritchard

Padhya

et al. 2020

BMJ Case Rep

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“… 10 Sites of metastasis such as skin have been rarely reported and are associated with poor prognosis. 11 This applies to our patient as his condition deteriorated shortly after the appearance of the cutaneous lesion.…”

Section: Discussionmentioning

confidence: 65%

Choriocarcinoma metastatic to the skin: A rare occurrence associated with dismal outcome

2021

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Germ cell tumors (GCTs) are a histologically heterogeneous group of tumors that arise from the primitive germ cell of the embryonic gonad. Choriocarcinoma is a variant of GCTs that is prone to hematogenous metastasis to the liver, lung, and brain. Cutaneous metastasis in choriocarcinoma is rarely encountered with only a few cases reported in literature. We report the case of a 28-year-old male presenting with lower back pain that, upon further work-up, was diagnosed with pure choriocarcinoma of the testes. Around 9 months after his initial presentation, he developed a cutaneous back lesion. Microscopic examination confirmed the presence of choriocarcinoma composed of mononuclear cytotrophoblasts which interweave with multinucleated syncytiotrophoblasts. The patient passed away 3 weeks after the onset of cutaneous metastasis.

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