Pure yolk sac tumour, post-pubertal type, arising from cryptorchid testes

Abstract

Yolk sac tumour (YST), the most common germ cell tumour (GCT) in infants and children, accounts for 80% of GCTs in this age group. 1 It is observed in only 2.4% of adult patients in their pure form since up to 42% of mixed GCTs have some component of the yolk sac. 2 We present a 46-year-old cryptorchid man who presented with complaints of abdominal lump, pain and altered bowel habits since 1 month. CT scan of the abdomen revealed a mass arising from the pelvic cavity with feeders predominantly from the left gonadal vessel. Mass was excised via exploratory laparotomy and sent for histological examination. Microscopic examination was suggestive of pure YST. Immunohistochemistry stained positive for cytokeratin, placental-like alkaline phosphatase, Glypican 3 and alpha fetoprotein. The patient succumbed prior to commencing chemotherapy. Pure YSTs of post-pubertal origins are extremely rare and are more aggressive than their prepubertal counterparts.

Pure yolk sac tumor of testis with lung metastasis in an adult patient - case report

“…To the best of our efforts, we could find four more reported cases in literature published in English between 2015 and 2019. Janugade et al reported a case of pure YST arising from cryptorchid testis in a 46-year-old male, who presented with a large abdominal lump extending from infra umbilical region to pelvis along with delayed bowel movement [ 6 ]. Murcia et al reported a similar case of pure YST in a 20-year-old male, who also had metastases to the liver, retroperitoneum, and lung [ 7 ].…”

Yolk Sac Tumor of Testis Diagnosed 10 years after Orchidopexy in 24-year-old Adult: A Case Report

“…Yolk sac tumors are rare in post-pubertal patients with cryptorchidism. Hemant et.al reported a yolk sac tumor in post-pubertal patients but the testis was intra-abdominal in their case 11 . Our patient histopathological specimen also revealed a yolk sac tumor which is a rare association.…”

“…The risk of malignancy decreases when orchidopexy is done before puberty 10 . Seminoma, a testicular germ cell tumor occurs most commonly in cryptorchidism 11 . Yolk sac tumors are rare in post-pubertal patients with cryptorchidism.…”

18F-FDG PET/CT in pure testicular Yolk Sac Tumor in adult

“…The typical perivascular pattern with the characteristic Schiller--Duval bodies was predominantly observed in the conserved areas (Figure 2A). These Schiller-Duval bodies are a hallmark of YST seen in 50%-75% of cases (3). YST that present with only one histological pattern are extremely rare (3).…”

“…These Schiller-Duval bodies are a hallmark of YST seen in 50%-75% of cases (3). YST that present with only one histological pattern are extremely rare (3).…”