Purely suprasellar (Hypothalamic) atypical teratoid rhabdoid tumor presenting with diabetes insipidus and panhypopituitarism in an adult male: A case report and review of literature

Abstract

Atypical teratoid rhabdoid tumor (ATRT) is a rare primary malignant tumor of the central nervous system. Little knowledge is available about natural history, behavior, prognosis, and best management guidelines of such tumor. Its occurrence in adults is very rare and more predominant in females. Locations in adults are mainly cerebral hemispheres, but recently, more cases are reported in sellar/suprasellar cisterns. We are reporting a case of purely suprasellar ATRT of a middle aged male who presented initially with diabetes insipidus (DI).

Atypical Teratoid Rhabdoid Tumor of the Pineal Region in a 33-Month-Old Child: A Case Report

“…Also, the immunochemistry and histopathological analysis shows a poorly differentiated malignant neoplasm, with this analysis is possible to visualize cells with a prominent nucleoli and broad cytoplasm, large hyperchromatic nuclei, associated with numerous mitoses, and apoptosis, as well as loss of integrase interactor-1 (INI-1), BRG1 protein, and a high Ki-67 proliferation index. ATRT can occur virtually in all locations of the central nervous system, including the pineal and suprasellar regions [24,25] .…”