1981
DOI: 10.1016/s0021-9258(18)42997-3
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Purification and characterization of a cytosolic broad specificity beta-glucosidase from human liver.

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Cited by 111 publications
(13 citation statements)
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“…It has a molecular mass of approx. 53 kDa, has a pH optimum of 5.5-6.0 and is not glycosylated [6]. It is inhibited by sodium taurocholate at very low concentrations [7,8].…”
Section: Introductionmentioning
confidence: 99%
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“…It has a molecular mass of approx. 53 kDa, has a pH optimum of 5.5-6.0 and is not glycosylated [6]. It is inhibited by sodium taurocholate at very low concentrations [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…It is inhibited by sodium taurocholate at very low concentrations [7,8]. In contrast with lysosomal β-glucosidase, cytosolic β-glycosidase is not inhibited by conduritol B epoxide [6,9]. It exhibits a high affinity for the β--glucoside and β--galactoside derivatives of 4-methylumbelliferone (4-MuGlc and 4-MuGal respectively) and p-nitrophenol [3].…”
Section: Introductionmentioning
confidence: 99%
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“…β-glucosidase (GBA) is capable of hydrolyzing glucosylceramide, and the cytosolic β-glucosidase (GBA3), a xenobiotic-metabolizing enzyme presents in liver and kidneys, hydrolyzes many types of glycosides [8,9]. The deficiency or mutation of GBA1, GBA2, and GBA3 results in an elevation of glucosylceramide level and then leads to GD, which is characterized by lysosomal storage disorders [15,16].…”
Section: Discussionmentioning
confidence: 99%
“…GBA3 is an enzyme with broad substrate specificity for the glycone moiety of various aryl-glycosides including β-D-fucosides, α-L-arabi nosides, β-D-glucosides, β-D-galactosides, β-L-xylosides, and β-D-arabinosides. In addition, GBA3 displays a conspicuous hydrolytic activity for several common dietary xenobiotics [7][8][9]. The two other types of β-glucosidase expressed in humans are the lysosomal enzyme, β-glucosidase 1 (GBA1), and the non-lysosomal β-glucosidase 2 (GBA2) [10,11].…”
mentioning
confidence: 99%