Purification and characterization of a toxin inhibiting protein synthesis from Croton mongue, a madagascar euphorbiaceae

Ralison, Charlotte; Creppy, E. E.; Boulanger, Yves; Dirheimer, G.

doi:10.1016/s0300-9084(86)80068-2

Cited by 4 publications

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“…According to the “efloras” database on the vascular plants of Madagascar, the genus Croton is represented by 139 species distributed in various ecological regions ranging from the eastern rainforests to the semiarid region of the south. Despite their ethnomedical uses, only five Madagascan species in the genus have been investigated phytochemically, namely, C. mongue, C. geayi, C. hovarum, C. antanosiensis, and C. sakamaliensis . − …”

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“…Despite their ethnomedical uses, only five Madagascan species in the genus have been investigated phytochemically, namely, C. mongue, C. geayi, C. hoVarum, C. antanosiensis, and C. sakamaliensis. [3][4][5][6][7] In the course of a continuing search for biologically active compounds from plants of Madagascar, nine Croton species in different regions of the island were collected. Ethyl acetate extracts of two species, namely, C. barorum Leandri and C. goudotii Baill., showed strong cytotoxic activities with 100% inhibition at 10 µg/ mL against the P388 murine lymphocytic leukemia cell line.…”

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Cytotoxic 3,4-seco-Atisane Diterpenoids from Croton barorum and Croton goudotii

et al. 2010

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In a screening program directed to the discovery of new anticancer agents from Madagascan plants, ethyl acetate extracts of Croton barorum and C. goudotii showed strong cytotoxic activity, with 100% inhibition at 10 μg/mL in a primary screen using the murine lymphocytic leukemia P388 cell line. Bioassay-guided fractionation led to the isolation of two new 3,4-seco-atisane diterpenoids, crotobarin (1) and crotogoudin (2). Their structures were elucidated by spectroscopic data interpretation. Compounds 1 and 2 produced a net progression in the number of cells arrested at the G2/M growth stage in the cell cycle of the K562 human leukemia cell line at 4 μM.

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